<abstract xmlns="http://www.w3.org/1999/xhtml">A previously established method based on headspace solidphase microextraction (HS-SPME) and comprehensive two-dimensional gas chromatography (GC×GC) coupled to time-of-flight mass spectrometry (TOFMS) has been used to evaluate and compare the profiles of semi-volatile compounds present in mainstream tobacco smoke particulate matter trapped on glass fibre filters for two types of cigarettes differing only in filter design. In the first cigarette, the filter cavity contained approximately 60 mg of a weakly basic macroporous polystyrene resin cross-linked with divinyl benzene and with surface amine functionality (CR20), whereas in the second cigarette, it was empty.Relative quantitative analysis, chemical identification, and chemical grouping allowed the use of both parametric and non-parametric analyses to identify differences in the chemical composition of the smokes from these cigarettes. The analysis demonstrated that in addition to the selective partial removal of volatile carbonyls and HCN demonstrated previously, CR20 selectively, but incompletely removed 316 compounds from the particulate phase of cigarette smoke, mainly aryl and aromatic hydrocarbons as well as other more volatile species. In contrast, the relative proportion of amines, hydroxylated aromatic compounds and less volatile species was increased in the smoke from the cigarette containing CR20 in the filter.Our findings show that high resolution GC techniques combined with mass spectrometry and chemometric approaches are powerful tools for deconvoluting the complexity of combustion aerosols, as well as helping to identify changes in chemical composition resulting from modifications to cigarette designs. [Beitr. Tabakforsch. Int. 28 (2019) 231–249]</abstract>

A previously established method based on headspace solidphase microextraction (HS-SPME) and comprehensive two-dimensional gas chromatography (GC×GC) coupled to time-of-flight mass spectrometry (TOFMS) has been used to evaluate and compare the profiles of semi-volatile compounds present in mainstream tobacco smoke particulate matter trapped on glass fibre filters for two types of cigarettes differing only in filter design. In the first cigarette, the filter cavity contained approximately 60 mg of a weakly basic macroporous polystyrene resin cross-linked with divinyl benzene and with surface amine functionality (CR20), whereas in the second cigarette, it was empty.Relative quantitative analysis, chemical identification, and chemical grouping allowed the use of both parametric and non-parametric analyses to identify differences in the chemical composition of the smokes from these cigarettes. The analysis demonstrated that in addition to the selective partial removal of volatile carbonyls and HCN demonstrated previously, CR20 selectively, but incompletely removed 316 compounds from the particulate phase of cigarette smoke, mainly aryl and aromatic hydrocarbons as well as other more volatile species. In contrast, the relative proportion of amines, hydroxylated aromatic compounds and less volatile species was increased in the smoke from the cigarette containing CR20 in the filter.Our findings show that high resolution GC techniques combined with mass spectrometry and chemometric approaches are powerful tools for deconvoluting the complexity of combustion aerosols, as well as helping to identify changes in chemical composition resulting from modifications to cigarette designs. [Beitr. Tabakforsch. Int. 28 (2019) 231–249]

Comparison of Mainstream Smoke Composition from CR20 Resin Filter and Empty-Cavity Filter Cigarettes by Headspace SPME Coupled with GC×GC TOFMS and Chemometric Analysis

CART - Chemistry Department, Organic & Biological Analytical Chemistry

Contributions to Tobacco & Nicotine Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

A previously established method based on headspace solidphase microextraction (HS-SPME) and comprehensive two-dimensional gas chromatography (GC×GC) coupled to...

Comparison of Mainstream Smoke Composition from CR20 Resin Filter and Empty-Cavity Filter Cigarettes by Headspace SPME Coupled with GC×GC TOFMS and Chemometric Analysis

Published Online: Jun 13, 2019

Page range: 231 - 249

Received: Dec 13, 2018

Accepted: Apr 05, 2019

DOI: https://doi.org/10.2478/cttr-2019-0004

Keywords
Solid-phase microextraction (SPME), Comprehensive twodimensional gas chromatography (GC×GC), Mainstream tobacco smoke particulate phase (PP), Fisher ratio, Chemometric analysis

© 2019 Michał Brokl et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Comparison of Mainstream Smoke Composition from CR20 Resin Filter and Empty-Cavity Filter Cigarettes by Headspace SPME Coupled with GC×GC TOFMS and Chemometric Analysis

Published Online: Jun 13, 2019

Page range: 231 - 249

Received: Dec 13, 2018

Accepted: Apr 05, 2019

DOI: https://doi.org/10.2478/cttr-2019-0004

KeywordsSolid-phase microextraction (SPME), Comprehensive twodimensional gas chromatography (GC×GC), Mainstream tobacco smoke particulate phase (PP), Fisher ratio, Chemometric analysis

© 2019 Michał Brokl et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Solid-phase microextraction (SPME), Comprehensive twodimensional gas chromatography (GC×GC), Mainstream tobacco smoke particulate phase (PP), Fisher ratio, Chemometric analysis