<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Oxidative stress is a basic mechanism involved in both ageand smoking-related diseases. To test whether smoking affects young, old, and calorie-restricted organisms to the same extent, we assessed oxidative stress parameters in the lung, heart, and liver of male Fischer 344 rats (4 months old and 19-22 months old) exposed to air or cigarette mainstream smoke. Smoke-related effects were seen for parameters of DNA damage, lipid peroxidation, protein oxidation, and glycoxidation. No smoke-related effects were observed for DNA damage in the lung and heart (Comet assay) and for malondialdehyde in the lung. The old rats showed higher smoke-related responses than the young rats for 8-hydroxy-desoxyguanosine (8-OHdG) in the heart and liver, DNA damage in the liver, and protein carbonyls in the lung; however, there was little evidence for an overadditive effect of smoking on aging. Caloric restriction, which is known to retard aging effects, also had little impact on smoke-related oxidative changes. [Beitr. Tabakforsch. Int. 26 (2014) 109-120]</p></abstract>

Oxidative stress is a basic mechanism involved in both ageand smoking-related diseases. To test whether smoking affects young, old, and calorie-restricted organisms to the same extent, we assessed oxidative stress parameters in the lung, heart, and liver of male Fischer 344 rats (4 months old and 19-22 months old) exposed to air or cigarette mainstream smoke. Smoke-related effects were seen for parameters of DNA damage, lipid peroxidation, protein oxidation, and glycoxidation. No smoke-related effects were observed for DNA damage in the lung and heart (Comet assay) and for malondialdehyde in the lung. The old rats showed higher smoke-related responses than the young rats for 8-hydroxy-desoxyguanosine (8-OHdG) in the heart and liver, DNA damage in the liver, and protein carbonyls in the lung; however, there was little evidence for an overadditive effect of smoking on aging. Caloric restriction, which is known to retard aging effects, also had little impact on smoke-related oxidative changes. [Beitr. Tabakforsch. Int. 26 (2014) 109-120]

Cigarette-Smoke- and Age-Dependent Oxidative Stress Effects in Rats

Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Cologne, Germany

Philip Morris International R&D, Philip Morris Products S.A., Neuchâtel, Switzerland

Philip Morris International R&D, Philip Morris Research Laboratories bvba, Leuven, Belgium

Helix3 Inc., Morrisville, NC, USA 5 Institute of Anatomy, Medical Faculty, Technical University Dresden, Germany

Institute of Anatomy, Medical Faculty, Technical University Dresden, Germany

Contributions to Tobacco & Nicotine Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Cigarette-Smoke- and Age-Dependent Oxidative Stress Effects in Rats"}

Oxidative stress is a basic mechanism involved in both ageand smoking-related diseases. To test whether smoking affects young, old, and calorie-restricted...

Cigarette-Smoke- and Age-Dependent Oxidative Stress Effects in Rats

Published Online: Nov 05, 2014

Page range: 109 - 120

Received: Mar 07, 2014

Accepted: Aug 22, 2014

DOI: https://doi.org/10.2478/cttr-2014-0014

© Beiträge zur Tabakforschung International

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.