Updates of CORESTA Recommended Methods after Further Collaborative Studies Carried Out under Both ISO and Health Canada Intense Smoking Regimes

During 2012, three CORESTA Recommended Methods (CRMs) (1-3) were updated to include smoke yield and variability data under both ISO (4) and the Canadian Intense (CI) (5) smoking regimes. At that time, repeatability and reproducibility data under the CI regime on smoke analytes other than “tar”, nicotine and carbon monoxide (6) and tobacco-specific nitrosamines (TSNAs) (7) were not available in the public literature. The subsequent work involved the determination of the mainstream smoke yields of benzo[a]-pyrene, selected volatiles (benzene, toluene, 1,3-butadiene, isoprene, acrylonitrile), and selected carbonyls (acetaldehyde, formaldehyde, propionaldehyde, butyraldehyde, crotonaldehyde, acrolein, acetone and 2-butanone) in ten cigarette products followed by statistical analyses according to the ISO protocol (8). This paper provides some additional perspective on the data variability under the ISO and CI smoking regimes not given in the CRMs.