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7. Oxalic acid [HOOC-COOH], which contains no C-H linkage, appeared to be an exception to the rule that a C-H linkage was a molecular necessity for the generation of PAHs. Oxalic acid does generale traces of PAHs on heating [Gilbert, J.A.S. and A.J. Lindsey: The thermal decomposition of some to-bacco constituents; Brit. J. Cancer 11 (1957) 398K402]. However, when heated, oxalic acid decom-poses to carbon dioxide and formie acid [H-COOH] that does contain the requisite C-H linkage.
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19. Snook, M.E, R.F. Severson, R.F. Arrendale, H.C. Higman, and O.T. Chortyk: The identification of high molecular weight polynuclear aromatic hydrocarbons in a biologically active fraction of cigarette smoke condensate; Beitr. Tabakforsch. Int. 9 (1977) 79K101.
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20. Rodgman, A.: Discussion of ROFFONs results with RJRT colleagues, June and July 1954: Solvent extraction of tobacco and its possible effect on the levels of PAHs in cigarette MSS were discussed between June 24 and July 9, 1954. During several informal meetings, these topics were discussed by Rodgman and Drs. M. Senkus and J. Gilbert Ashburn. From knowledge gained in PAH carcinogenesis research at the Banting and Best Department of Medical Research, University of Toronto, Rodgman cited the report by ROFFO (21) on ethanol extraction of to-bacco and the reduction of specific tumorigenicity (rabbit skin painting) and PAH content of the Pde-structive distillateQ from the extracted tobacco vs the Pdestructive distillateQ from control tobacco. Rodg-man noted that ROFFO had postulated that ethanol extraction removed phytosterols, possible PAH pre-cursors, from the tobacco. Subsequently, ASHBURN authored a Conception of Invention Memorandum [Ashburn, J.G.: The production of a sterol-free ciga-rette; CIM, 1954, No. 17, July 9 (INT-502476757 -6758)] based on information he obtained during the Rodgman-Senkus-Ashburn meeting.
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22. Rodgman, A. and L.C. Cook: The analysis of ciga-rette smoke condensate. V. The polycyclic hydrocar-bon precursors in tobacco; RDR, 1958, No. 18, De-cember 1 (INT-501008387-8441).
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27. Newell, M.P., R.A. Heckman, R.F. Moates, C.R. Green, F.W. Best, and J.N. Schumacher: The composition of the ether-soluble portion of the particulate phase of cigarette smoke; 29th Tobacco ChemistsN Research Conference, Program Booklet and Abstracts, Vol. 29, Paper No. 39, 1975, p. 28; Isolation and identification of new components of the ether-soluble portion of cigarette smoke condensate; Tob. Sci. 22 (1978) 6K11.
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34. Rodgman, A.: The analysis of cigarette smoke condensate. XIX. The determination of polycyclic aromatic hydrocarbons; RDR, 1961, No. 1, January 6(INT-500935976-5996).
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43. Philip Morris Inc.: Chemical constituents in tobacco and smoke. A compilation of published information; Philip Morris Inc., Richmond VA, 1963, pp. 47 (INT-501013285 -3339; www.pmdocs.com 1005136992/7049; 2024948517/8518).
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44. Rodgman, A. and L.C. Cook: The composition of cigarette smoke; Unpublished data, 1955K1964. Pre-sented in part at Sigma Xi Meeting, Wake Forest University, Winston-Salem, N.C., 17 March, 1965 (INT-501521599 -2606), American Chemical Society Section Meeting, Columbus, GA, 2 May, 1968 (INT-501521608 -1625), and Central North Carolina Section Meeting, American Chemical Society, Greensboro, N.C., 14 October, 1969 (INT-501521658 -1700).
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45. P. Lorillard Company Research Laboratory: Selective filtration of phenol by Kent's improved Micro-nite filter; P. Lorillard Co., Greensboro NC: 1K4 (1962); Hoffmann, D. and E.L. Wynder: Die Filtration von Phenolen aus Cigarettenrauch; Beitr. Tabakforsch. 2 (1963) 51K66; Filtration of phenols from cigarette smoke; J. Natl. Cancer Inst. 30 (1963) 67K84; Laurene, A.H.: Adsorption of phenol by un-treated Estron®; RDM, 1963, No. 5, January 8 (INT-500612340 -2343. 4); Evaluation of Triacetate B as a cigarette filter materiał; RDM, 1963, No. 6, January 8 (INT-500612344 -2346); Laurene, A.H., G.W. Young, and L.A. Lyerly: Factors which affect the phenol content of cigarette smoke; RDR, 1963, No. 58, November 13 (INT-500962130 -2163); Wynder, E.L. and D. Hoffmann: Tobacco and tobacco smoke: Studies in experimental carcinogenesis; Academic Press, New York NY, 1967, see p. 626; Wynder, E.L. and D. Hoffmann: Experimental tobacco carcinogenesis; Science 162 (1968) 862K871; Wynder, E.L. and D. Hoffmann: A study of tobacco carcinogenesis. X. Tumor promoting activity; Cancer 24 (1969) 289K301.
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47. Rodgman, A, S.S. Mims, and L.C. Cook: Some comments on ciliary inhibition; RDM, 1964, No. 45, April 28 (INT-500602286 -2294) 48. Dalhamn, T, M.L. Edfors, and R. Rylander: Mouth absorption of various compounds in cigarette smoke; Arch. Environ. Hlth. 16 (1968) 831K835; Retention of cigarette smoke components in human lungs; Arch. Environ. Hlth. 17 (1968) 746K748.
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49. Rodgman, A.: 7V-Nitrosamines were predicted as cigarette MSS components during a 1960 meeting with Dr. Murray Senkus and others; subsequently, the 7V-nitrosamines in tobacco smoke were predicted by others, e.g., Druckrey, H. and R. Preussmann: Zur Entstehung carcinogener Nitrosamine am Bei-spiel des Tabakrauchs; Naturwissenschaften 49 (1962) 498K499.
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56. Ashburn, J.G.: Magnesium nitrate as a tobacco additive; CIM, 1957, No. 19, September 30 (INT-504175222 -5223; 503132383 -2385).
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