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Mini-Review: On the Transfer of Nicotine from Tobacco to the Smoker. A Brief Review of Ammonia and “pH” Factors


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1. Akehurst, B.C, Tobacco; 2”ded., Longmans, London, 1981.Search in Google Scholar

2. Leffingwell, J.C.: Basic chemical constituents of tobacco leaf and differences among tobacco types; in: Tobacco: production, chemistry and technology, edited by D.L. Davis and M.T. Nielsen, Blackwell Science Ltd, Oxford, 1999, pp. 265-84.Search in Google Scholar

3. Stedman, R.L.: The chemical composition of tobacco and tobacco smoke; Chem. Rev. 68 (1968) 153-207.Search in Google Scholar

4. Shmuk, A.A.: The chemistry and technology of tobacco; Pioschepromizdat, Mosków, 1953.Search in Google Scholar

5. Seeman, J.I, J.A Fournier, J.B. Paine III and B.E. Waymack: Thermal properties of nonprotonated and protonated nicotine. The use of thermolysis as a model for smoke formation chemistry; J. Agric. Food Chem. 47 (1999) 5133-5145.Search in Google Scholar

6. Rickert, W.S.: Partial characterization of 10 ‘common’ brands of American cigarettes; Project Report prepared for the Massachusetts Department of Public Health, Labstat, Inc., Kitchener, ON, January 30, 1997.Search in Google Scholar

7. Brunnemann, K.D., and D. Hoffmann: Gas chromatographic determination of ammonia in cigarette and cigar smoke; J. Chromat. Sci. 13 (1975) 159-163.Search in Google Scholar

8. Sloan, C.H., and G.P. Morie: Determination of ammonia in tobacco and tobacco smoke with an ammonia electrode; Anal. Chim. Acta. 69 (1974) 243-247.Search in Google Scholar

9. Baker, R.B.: Smoke chemistry; in: Tobacco. Production, chemistry and technology, edited by D.L. Davis and M.T. Nielsen, Blackwell Science, Oxford, 1999, pp. 398-439.Search in Google Scholar

10. Browne, CL.: The design of cigarettes; Hoechst Celanese Corporation, Charlotte, NC, 1990.Search in Google Scholar

11. Hind, J.D., and R.B. Seligman: Method of preparing a reconstituted tobacco sheet employing a pectin adhesive; Philip Morris, US Patent 3,420,241, January 7, 1969.Search in Google Scholar

12. Leffingwell, J.C.: Nitrogen components of leaf and their relationship to smoking quality and aroma; Rec. Adv. Tob. Sci. 2 (1976) 1-31.Search in Google Scholar

13. Leffingwell, J.C., and D. Leffingwell: Chemical and sensory aspects of tobacco flavor - an overview; Rec. Adv. Tob. Sci.7 (1981) 169-217.Search in Google Scholar

14. Ellis, CL., R.H. Cox, C.H. Callicutt, S.W. Laffoon, K.F. Podraża, J.I. Seeman, R.D. Kinser, D.E. Farthing, and F.H. Hsu: The effect of ingredients added to tobacco in a commercial Marlboro Lights cigarette on FTC nicotine yield, “smoke pH” and Cambridge filter trapping efficiency; CORESTA Smoke and Technology Meeting, Innsbruck/ Austria, September 5-8, CORESTA Buli. No. 3, 1999, p 108.Search in Google Scholar

15. Johnson, W.R., R.W. Hale, S.C. Clough, and P.H. Chen: Chemistry of the conversion of nitrate nitrogen to smoke products; Naturę 243 (1973) 223-225.Search in Google Scholar

16. Osdene, T.S.: Reaction mechanisms in the burning cigarette; in: The recent chemistry of natural products, including tobacco, edited by N.J. Fina, Philip Morris, Richmond, VA, 1975, pp. 41-60.Search in Google Scholar

17. Kessler, D.A.: The control and manipulation of nicotine in cigarettes; Subcommittee on Health and the Environment Committee on Energy and Commerce, U.S. House of Representatives, July 21, 1994.Search in Google Scholar

18. Kessler, D.A., P.S. Barnett, A.M. Witt, M.R. Zeller,J.R. Mande, andW.B. Schultz: The legał and scientific basis for FDA's assertion of jurisdiction over cigarettes and smokeless tobacco; J. Am. Med. Assoc. 227 (1997) 405-409.Search in Google Scholar

19. Hurt, R.D., and CR. Robertson: Prying open the door to the tobacco industry's secrets about nicotine; J. Am. Med. Assoc. 280 (1998) 1173-1181.Search in Google Scholar

20. Bates, C, M. Jarvis, and G. Connolly: Tobacco additives - cigarette engineering and nicotine addiction; Action on Smoking and Health Web Site, http://www.ash.org.uk/papers/ additives.html, July 14, 1999.Search in Google Scholar

21. Fournier, J.A, J.B. Paine III, J.I. Seeman, D.A. Armstrong, and X. Chen: Thermal mechanisms for the transfer of amines, including nicotine, to the gas phase and aerosols; submitted for publication.Search in Google Scholar

22. Obi, Y., Y. Shimada, K. Takahashi, K. Nishida, T. Kisaka: Reaction products of nicotine with ethylene oxide and their pyrolysis; Tob. Sci. 12 (1968) 70-74.Search in Google Scholar

23. Perfetti, T., A.B. Norman, B.M. Gordon, W.M. Coleman III, G.M. Duli, and W.C Miller: The transfer of nicotine from nicotine salts to main-stream smoke; Beitr. Tabakforsch. Int., accepted for publication.Search in Google Scholar

24. Brunnemann, K.D., and D. Hoffmann: The pH of tobacco smoke; Food Cosmet. Toxicol. 12 (1974) 115-124.10.1016/0015-6264(74)90327-7Search in Google Scholar

25. Morie, G.P.: Fraction of protonated and unprotonated nicotine in tobacco smoke at various pH values; Tob. Sci. 16 (1972) 167.Search in Google Scholar

26. Wolf, F.A.: Aromatic or Oriental tobaccos; Duke University Press, Durham, NC, 1962.Search in Google Scholar

27. Dong, J.-Z., J.N. Glass, T. Thompson, B.F. Price, J.H. Lauterbach, and S.C. Moldoveanu: A simple technique for determining the pH of whole cigarette smoke; Beitr. Tabakforsch. Int. 19 (2000) 33-48.Search in Google Scholar

28. Elson, L.A., T.E. Betts, and R.D. Passy: The sugar content and the pH of the smoke of cigarette, cigar and pipę tobaccos in relation to lung cancer; Int. J. Cancer 9 (1972) 666-675.Search in Google Scholar

29. Grób, K.: Die Bestimmungdes pH-Wertes und derPufferungkapazitat des Cigarettenrauches ais Routine-Methode; Beitr. Tabakforsch. 1 (1961) 97-100.Search in Google Scholar

30. Callicutt, E.H., J.M. Garman, J.M. Shackleford, and K. Walker: pH determination of an aqueous solution of mainstream cigarette smoke; 52n Tobacco Science Research Conference, Atlanta, Georgia, 1998, Program Booklet and Abstracts, Vol. 52, no. 8, p. 19.Search in Google Scholar

31. Harris, J.L., and L.E. Hayes: A method for measuring the pH value of whole smoke; Tob. Sci. 21 (1977) 58-60.Search in Google Scholar

32. Sensabaugh, A.J, and R.H. Cundiff: A new technique for determining the pH of whole tobacco smoke; Tob. Sci. 11 (1967) 25-30.Search in Google Scholar

33. Hoffmann, D, G. Rathkamp, K.D. Brunnemann, and E.L. Wynder: On the profile analysis of tobacco smoke; Sci. Total Environ. 2 (1973) 157-171.Search in Google Scholar

34. Rickert, W.S., J.C. Robinson, and B. Rogers: A comparison of tar, carbon monoxide, and pH levels in smoke from marihuana and tobacco cigarettes; Can. J. Public Health 73 (1982) 386-391.Search in Google Scholar

35. Lewis, D.A., I. Colbeck, and D.C. Mariner: Diffusion of mainstream tobacco smoke and its effects upon the evaporation and diffusion of nicotine; Anal. Chem. 66 (1994) 3525-3527.Search in Google Scholar

36. Mariner, D.C, and B.E. Frost.: Determination of nicotine evaporation from mainstream smoke using denudertubes; Proceedings of the CORES-TA Congress, October 1998, Brighton, England, pp. 206-210.Search in Google Scholar

37. Panków, J.F., B.T. Mader, L.M. Isabelle, W. Luo, A. Pavlick, and C. Liang: Conversion of nicotine in tobacco smoke to its volatile and available free-base form through the action of gaseous ammonia; Environ. Sci. Technol. 31 (1997) 2429-2433.Search in Google Scholar

38. Rodgman, A.: FTC “tar” and nicotine in mainstream smoke: a retrospective; Rec. Adv. Tob. Sci. 23 (1997) 5-74.Search in Google Scholar

39. Houseman, T.H.: Studies of cigarette smoke transfer using radio-isotopically labelled tobacco constituents. Part II: The transference of radioisotopically labelled nicotine to cigarette smoke; Beitr. Tabakforsch. 7(1973)142-147.Search in Google Scholar

40. Stevens, N.A., and M.F. Borgerding: GC-AED studies of nicotine fate in a burning cigarette; Anal. Chem. 72 (1999) 2179-2185.Search in Google Scholar

41. Kinser, R.D., F.H. Hsu, D.E. Farthing, L.D. Johnson, and CL. Ellis: Nicotine collection efficiency in the FTC nicotine method; 53rd Tobacco Science Research Conference, Montreal, Canada, 1999, Program Booklet and Abstracts, Vol. 53, no. 46, p. 45.Search in Google Scholar

42. Lunęli, E., L. Molander, K. Ekberg, and J. Wahren: Site of nicotine absorption from a vapour inhaler - comparison with cigarette smoking; Eur. J. Clin. Pharmacol. 55 (2000) 737-741.Search in Google Scholar

43. Lunęli, E, M. Bergstrom, G. Antoni, B. Langstrom, and A. Nordbert: Nicotine deposition and body distribution from a nicotine inhaler and a cigarette studied with positron emission tomography; Clin. Pharmacol. Ther. (1996) 593-594.Search in Google Scholar

44. Bergstrom, M., A. Nordberg, E. Lunęli, G. Antoni, and B. Langstrom: Regional deposition of inhaled “Cnicotine vapor in the human airway as yisualized by position emission tomography; Clin. Pharmacol. Ther. 57 (1995) 309-317.Search in Google Scholar

45. Molander, L., E. Lunęli, S.-B. Andersson, and F. Kuylenstierna: Dose released and absolute bioavailability of nicotine from a nicotine vapor inhaler; Clin. Pharmacol. Ther. 59 (1996) 394-400.Search in Google Scholar

46. Schuh, K.J, L.M. Schuh, J.E. Henningfield, and M.L. Stitzer: Nicotine nasal spray and vapor inhaler: abuse liability assessment; Psycho-pharmacology 130 (1997) 352-361.Search in Google Scholar

47. Russell, M.A.H, and C Feyerabend: Cigarette smoking: adependence on high-nicotine boli; Drug Metabolism Reviews 8 (1978) 29-57.Search in Google Scholar

48. Russell, M.A.H., M.J. Jarvis, G. Sutherland, and C Feyerabend: Nicotine replacement in smoking cessation; J. Amer. Med. Assoc. 257 (1987) 3262-3265.Search in Google Scholar

49. Benowitz, N.L.: Nicotinepharmacology and addiction; in: Nicotine safety and toxicity, edited by N.L. Benowitz, Oxford University Press, New York, 1998, pp. 3-16.Search in Google Scholar

50. Gori, G.B., N.L. Benowitz, and C.J. Lynch: Mouth versus deep airways absorption of nicotine in cigarette smokers; Pharm. Biochem. Behav. 25 (1986)1181-1184.Search in Google Scholar

51. Frost, B.E., D.C. Mariner, and N.M. Sinclair: Factors relatingto nicotine physio-chemistry and retention in human smokers; CORESTA Congress, Brighton, England, 1998, pp. 211-218.Search in Google Scholar

52. Lewis, D.A., I. Colbeck, and D.C. Mariner: Diffusion of mainstream tobacco smoke and its effects upon the evaporation and diffusion of nicotine; J. Aerosol Sci. 26 (1994) 841-846.Search in Google Scholar

53. Ingebrethsen, B.: Aerosol studies of cigarette smoke; Rec. Adv. Tob. Sci. 12(1986)54-142.Search in Google Scholar

54. McRae, D.D.: The physical and chemical naturę of tobacco smoke; Rec. Adv. Tob. Sci. 16 (1990) 233-323.Search in Google Scholar

55. Prodi, V. and A. Mularoni: Particulate deposition in smoking; in: Smoking and the lung; edited by G. Cumming and G. Bonsignore, Plenum Press, New York and London, 1984, pp. 249-285.10.1007/978-1-4613-2409-6_16Search in Google Scholar

56. Dalhamn, T., M.-L. Edfors, andR. Rylander: Mouth absorption ofvarious compounds in cigarette smoke; Arch. Environ. Health 16 (1968) 831-835.Search in Google Scholar

57. Newman, S.P.: Aerosol deposition characteristics in inhalation therapy; Chest88(1985)152S-160S.10.1378/chest.88.2_Supplement.152SSearch in Google Scholar

58. Liang, C. and J.F. Panków: Gas/particle partitioning of organie compounds to environmental smoke: Partition coefficient measurments by desorption and comparison to urban particulate matter; Environ. Sci. Technol. 30 (1996) 2800-2805.Search in Google Scholar

59. Trowbridge,C.G.J.P. Snyder,J.I. Seeman,andP.J. Lipowicz:Simulation of volatile loss from tobacco smoke using the aqueous system ammonia, acetic acid, and nicotine; submitted for publication.Search in Google Scholar

60. Egle, J.: Retention of inhaled acetone and ammonia in the dog; Am. Ind. Hyg. Assoc. J. 34 (1973) 533-539.Search in Google Scholar

61. Diller, W.F.: Acute irritant gas inhalation - classification and pathophys-iology; Zentralbl. Arbeitsmed. Arbeitsschutz Ergon. 47 (1997) 96-100.Search in Google Scholar

62. Benowitz, N.L., H. Porchet, P. Jacob III: Nicotine dependence and tolerance in man: pharmacokinetic and pharmacodynamic investigations; in: Progress in brain research, Vol. 79, edited by A. Nordberg, K. Fuse, B. Holmstedt, and A. Sundwall, Elsevier Science Publishers, B.V., 1989, pp. 279-287.10.1016/S0079-6123(08)62487-5Search in Google Scholar

63. Schievelbein, H.: Nicotine, resorption and fate; Pharmacol. Ther. 18 (1982) 233-248.Search in Google Scholar

64. Slade, J.: Nicotine delivery devices; in: Nicotine addiction: principles and management, Vol. 4; edited by C.T. Orleans and J. Slade, Oxford University Press, Oxford, 1993 pp. 3-23.Search in Google Scholar

65. Gourley, S.G., J.J. and McNeil: Antismoking products; Med. J. Aust. 153 (1990) 699-707.10.5694/j.1326-5377.1990.tb126327.x2246997Search in Google Scholar

66. Benet, L.Z., D.L. Kroetz, and L.B. Sheiner: Pharmacokinetics; in: Goodman and Gilman's the pharmacological basis of therapeutics, 9th ed., edited by J.G. Hardman and L-.E. Limbird, McGraw-Hill, New York, 1996, pp. 3-28.Search in Google Scholar

67. Rosę, J.E., F.M. Behm, E.C. Westman, and R.E. Coleman: Arerial nicotine kinetics during cigarette smoking and intravenous nicotine administration: implications for addiction; Drug Alcohol Dependence 56 (1999)99-107.Search in Google Scholar

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