The Chemical Evaluation of a Continuous-Smoking Inhalation Machine

The paper describes experiments which have been used to evaluate an inhalation smoking machine for small animals. Deliveries of undiluted and diluted smoke from this machine have been compared to reference data obtained from an analytical smoking machine. Deliveries of smoke immediately behind the smoke pump were lower than those from the analytical machine, largely due to differences in puff number (created largely by differences in paper regression between puffs) and deposition. When these factors were accounted for, deliveries from the two machines compared favourably. However, deliveries of diluted smoke, although apparently independent of dilution level, were somewhat lower than analytical deliveries. Thus the inhalation machine delivered about 65 % of the particulate matter, 80 % of the nicotine and 85 % of the carbon monoxide delivered by the analytical machine on a per puff basis (for 100 % tobacco or 50 % tobacco : 50 % Cytrel). A 100 % Cytrel cigarette delivered 80 % of the particulate matter and 90 % of the carbon monoxide (no nicotine). After accounting for deposition, consistent deliveries of about 85 % were achieved for all three constituents in all-tobacco cigarettes, while corrected deliveries for 100 % Cytrel cigarettes were about 90 % for both particulate matter and carbon monoxide. Deliveries of hydrogen cyanide and total volatile aldehydes in both samples were about 85 % of those achieved on an analytical machine