Metabolism study of morpholinium 2- ((4- (2-methoxyphenyl)-5-(pyridin-4-yl) -4H-1,2,4-triazole-3-yl)thio) acetate

1. Kaplaushenko AG. Research to create a new original national drug on the basis of 1,2,4-triazoles. Scientific Journal of the Ministry of Health of Ukraine. 2013;2:115-21.Search in Google Scholar

2. Varynskyi BO, Kaplaushenko AG. The development and validation of HPLC-DMD method for intermediate products impurities determination of morpholinium 2-((4-(2-methoxyphenyl)-5-(pyridine-4-yl)-4H-1,2,4-triazole-3-yl)thio) acetate in bulk drug. Zaporozhye Med J. 2017;3:373-80.Search in Google Scholar

3. Varynskyi B, Kaplaushenko A, Al Zidan F. Development And Validation of HPLC-DAD Method Of Determination Morpholin-4-ium 2-((4-(2-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl) thio) acetate In A Bulk Drug. RJPBCS. 2018;9(5):2200-9.10.14739/2310-1210.2017.3.100947Search in Google Scholar

4. Varynskyi B, Kaplaushenko A. The Force Degradation Study of the Morpholinium 2-((4-(2-Methoxyphenyl)-5-(Pyridin-4-YL)-4H-1,2,4-Triazol-3-YL) Thio) Acetate. Indones J Pharm. 2019;30(1):25-34.10.14499/indonesianjpharm30iss1pp25Search in Google Scholar

5. Shcherbyna R, Parchenko V; Varynskyi B; Kaplaushenko A. The development of HPLC-DAD method for determination of active pharmaceutical ingredient in the potassium 2-((4-amino-5-(morpholinomethyl)-4H-1,2,4-triazol-3-yl)thio)acetate substance. Curr Issues Pharmy Med Sci. 2019;1:5-9.10.2478/cipms-2019-0001Search in Google Scholar

6. https://www.drugbank.ca/drugs/DB06742Search in Google Scholar

7. Rousu T. Liquid chromatography–mass spectrometry in drug metabolism studies. Oulu: University of Oulu, 2012:17-20.Search in Google Scholar

8. A handbook of bioanalysis and drug metabolism. Edited by Gary Evans. Boca Raton London New York Washington: CRC PRESS, 2004:223-258, 259, 312.Search in Google Scholar

9. Parchenko VV, Kaplaushenko AG, Panasenko OI, Knysh YeG. Determination of possible metabolites of some S-derivatives 1,2,4-triazoles. Ukr Biopharm J. 2010;5(10):32-7.Search in Google Scholar

10. Scholz I, Oberwittler H, Riedel Kl-D, Burhenne J, Weiss J, Haefeli WE, Mikus G. Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype. BJCP. 2009;68(6):906-15.10.1111/j.1365-2125.2009.03534.xSearch in Google Scholar

11. Kaplaushenko AG. Synthesis, structure and biological activity of 4-mono- and 4,5-derivatives 1,2,4-triazoles-3-thione. Doctor of PharmSci thesis. Zaporozhye: Zaporozhye State Medical University; 2012.Search in Google Scholar

12. Lebedev АТ. Mass-spectrometry in organic chemistry. Мoskow: Binom, Laboratory of knowledges; 2003:258.Search in Google Scholar

13. Benoit F, Holmes JL. The mass spectra of carboxyltc acids-I: fragmentation mechanisms in maleic and fumaric acids and related compounds. OMS. 1969;2:591-601.10.1002/oms.1210020605Search in Google Scholar

14. Holmes JL, Benoit F. The mass spectra of carboxylic acids-III: the structures of molecular and fragment ions in benzoic acid and related molecules. OMS. 1970;4:97-107. https://doi.org/10.1002/oms.121004011110.1002/oms.1210040111Search in Google Scholar

15. Ansher SS, Jakoby WB. Amine N-methyltransferases from rabbit liver. J Biol Chem. 1986;261(9):3996-4001.10.1016/S0021-9258(17)35612-0Search in Google Scholar

16. Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB. Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases. Biochem Pharmacol. 1988;37(9):1673-7.10.1016/0006-2952(88)90426-1Search in Google Scholar