<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Bilayer and multi-layer tablets are enjoying growing popularity among original drug and generic product manufacturers. Multi-layer tablets have many key benefits compared to classic immediate-release tablets. The use of such solid oral dosage forms simplifies dosing regimens in combination therapy, and thus improves patient compliance. However, the technology of multilayer tablets is demanding and requires precise choice of excipients and production parameters with regard to each technological step. The main benefits of multi-layer tablets, certain aspects of their production and the challenges encountered during the compression process are reviewed in this paper.</p>
</abstract>

Bilayer and multi-layer tablets are enjoying growing popularity among original drug and generic product manufacturers. Multi-layer tablets have many key benefits compared to classic immediate-release tablets. The use of such solid oral dosage forms simplifies dosing regimens in combination therapy, and thus improves patient compliance. However, the technology of multilayer tablets is demanding and requires precise choice of excipients and production parameters with regard to each technological step. The main benefits of multi-layer tablets, certain aspects of their production and the challenges encountered during the compression process are reviewed in this paper.

Challenges in technology of bilayer and multi-layer tablets: a mini-review

Chair and Department of Rehabilitation and Orthopedics

Chair and Department of Applied and Social Pharmacy

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Challenges in technology of bilayer and multi-layer tablets: a mini-review"}

Bilayer and multi-layer tablets are enjoying growing popularity among original drug and generic product manufacturers. Multi-layer tablets have many key...

Challenges in technology of bilayer and multi-layer tablets: a mini-review

Published Online: Dec 31, 2019

Page range: 229 - 235

Received: Mar 07, 2019

Accepted: Apr 03, 2019

DOI: https://doi.org/10.2478/cipms-2019-0039

Keywords
bilayer tablet, multi-layer tablet, challenges in technology, compression

© 2019 Tomasz Blicharski et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Challenges in technology of bilayer and multi-layer tablets: a mini-review

Published Online: Dec 31, 2019

Page range: 229 - 235

Received: Mar 07, 2019

Accepted: Apr 03, 2019

DOI: https://doi.org/10.2478/cipms-2019-0039

Keywordsbilayer tablet, multi-layer tablet, challenges in technology, compression

© 2019 Tomasz Blicharski et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
bilayer tablet, multi-layer tablet, challenges in technology, compression