<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The purpose of the current research is to optimize the synthesis of sodium hyaluronatetitanium dioxide nanocomposite with the highest anticancer activity. To this end, the Taguchi method was followed to design nine experiments with different ratios of sodium hyaluronate biopolymer, titanium dioxide nanoparticles and stirring times. The results of scanning electron microscopy (SEM) confirmed the synthesis of the nanoparticle and nanocomposite. The comparison of anticancer activity level of synthesized nanocomposites using MTT assay showed that the nanocomposite synthesized in the conditions of experiment 9 (8 mg/ml of titanium dioxide nanoparticles, 2 mg/ml of sodium hyaluronate biopolymer and 60 min stirring time) had the maximum anticancer activity against Michigan Cancer Foundation-7 (MCF-7) cell line. According to the results, the Taguchi method can be employed as an effective and useful strategy to save time and cost in order to determine the optimal conditions for the synthesis of sodium hyaluronate-titanium dioxide nanocomposite with the most favorable anticancer activity.</p></abstract>

The purpose of the current research is to optimize the synthesis of sodium hyaluronatetitanium dioxide nanocomposite with the highest anticancer activity. To this end, the Taguchi method was followed to design nine experiments with different ratios of sodium hyaluronate biopolymer, titanium dioxide nanoparticles and stirring times. The results of scanning electron microscopy (SEM) confirmed the synthesis of the nanoparticle and nanocomposite. The comparison of anticancer activity level of synthesized nanocomposites using MTT assay showed that the nanocomposite synthesized in the conditions of experiment 9 (8 mg/ml of titanium dioxide nanoparticles, 2 mg/ml of sodium hyaluronate biopolymer and 60 min stirring time) had the maximum anticancer activity against Michigan Cancer Foundation-7 (MCF-7) cell line. According to the results, the Taguchi method can be employed as an effective and useful strategy to save time and cost in order to determine the optimal conditions for the synthesis of sodium hyaluronate-titanium dioxide nanocomposite with the most favorable anticancer activity.

<italic>In vitro</italic> evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite

Advanced Dental Sciences Research Laboratory

Kermanshah University of Medical Sciences

Department of Nanobiotechnology, Faculty of Science

Department of Orthodontics, School of Dentistry

Department of Prosthodontics, School of Dentistry

Institute of Medical Sciences, Banaras Hindu University

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

 evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite

The purpose of the current research is to optimize the synthesis of sodium hyaluronatetitanium dioxide nanocomposite with the highest anticancer activity. To...

In vitro evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite

Published Online: Jul 02, 2019

Page range: 99 - 103

Received: Sep 16, 2018

Accepted: Mar 11, 2019

DOI: https://doi.org/10.2478/cipms-2019-0019

Keywords
Anticancer, nanocomposite, Taguchi method, TiO nanoparticles, sodium hyaluronate, biopolymer

© 2019 Mohsen Safaei et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

In vitro evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite

Published Online: Jul 02, 2019

Page range: 99 - 103

Received: Sep 16, 2018

Accepted: Mar 11, 2019

DOI: https://doi.org/10.2478/cipms-2019-0019

KeywordsAnticancer, nanocomposite, Taguchi method, TiO nanoparticles, sodium hyaluronate, biopolymer

© 2019 Mohsen Safaei et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Anticancer, nanocomposite, Taguchi method, TiO nanoparticles, sodium hyaluronate, biopolymer