<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The article describes the results of histological and morphometric studies of liver in Balb/c mice with hemorrhagic stroke. The hemorrhagic stroke was modeled in the animals by administering autoblood in volume of 0.1 ml in the right hemisphere, and within 5, 10 and 30 days an analysis of structural changes in the liver was performed. Progressive changes were established in terms of 5-10 days of the experiment. This consisted of changes in the sinusoidal capillaries and notable changes in the central veins of the liver lobuli. Herein, acute dilatation and erythrocytal stasis were most pronounced around the lumen of the central veins, while hepatocytes with signs of necrosis (severe cytoplasmic swelling, vacuolar dystrophic changes) were detected in the sinusoid capillaries. The results of the morphometry indicated an increase in the area of the nucleus and the cells caused by intracellular swelling, domination of euchromatin and decrease of total density of chromatin in nuclei. Partial regression of the diameter of sinusoidal capillaries and the area of hepatocytes were detected on the 30<sup>th</sup> day of the experiment. The changes in the sinusoidal capillaries of the liver lobules are assessed as secondary to stroke, as well as to changes in organ microcirculation, and are associated with dystrophic changes in the hepatocytes.</p></abstract>

The article describes the results of histological and morphometric studies of liver in Balb/c mice with hemorrhagic stroke. The hemorrhagic stroke was modeled in the animals by administering autoblood in volume of 0.1 ml in the right hemisphere, and within 5, 10 and 30 days an analysis of structural changes in the liver was performed. Progressive changes were established in terms of 5-10 days of the experiment. This consisted of changes in the sinusoidal capillaries and notable changes in the central veins of the liver lobuli. Herein, acute dilatation and erythrocytal stasis were most pronounced around the lumen of the central veins, while hepatocytes with signs of necrosis (severe cytoplasmic swelling, vacuolar dystrophic changes) were detected in the sinusoid capillaries. The results of the morphometry indicated an increase in the area of the nucleus and the cells caused by intracellular swelling, domination of euchromatin and decrease of total density of chromatin in nuclei. Partial regression of the diameter of sinusoidal capillaries and the area of hepatocytes were detected on the 30th day of the experiment. The changes in the sinusoidal capillaries of the liver lobules are assessed as secondary to stroke, as well as to changes in organ microcirculation, and are associated with dystrophic changes in the hepatocytes.

Structural changes in liver under conditions of experimental hemorrhagic stroke

O.O. Bogomolets National Medical University

Current Issues in Pharmacy and Medical Sciences

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{"article-title":"Structural changes in liver under conditions of experimental hemorrhagic stroke"}

The article describes the results of histological and morphometric studies of liver in Balb/c mice with hemorrhagic stroke. The hemorrhagic stroke was modeled...

Structural changes in liver under conditions of experimental hemorrhagic stroke

Published Online: Jul 02, 2019

Page range: 67 - 70

Received: May 31, 2018

Accepted: Oct 04, 2018

DOI: https://doi.org/10.2478/cipms-2019-0013

Keywords
liver, stroke, capillary sinusoids, hepatocytes injury

© 2019 Natalia Motorna, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Structural changes in liver under conditions of experimental hemorrhagic stroke

Published Online: Jul 02, 2019

Page range: 67 - 70

Received: May 31, 2018

Accepted: Oct 04, 2018

DOI: https://doi.org/10.2478/cipms-2019-0013

Keywordsliver, stroke, capillary sinusoids, hepatocytes injury

© 2019 Natalia Motorna, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
liver, stroke, capillary sinusoids, hepatocytes injury