<abstract xmlns="http://www.w3.org/1999/xhtml">Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the regulation of the functioning of the gastrointestinal tract, including that of the colon. The response of smooth muscles, blood vessels and colon mucosa (CM) to 5-HT is realized through the activation of various types of 5-HT receptors, in particular, 5-HT4 receptors, since the latter are identified on colon cells membranes (enterocytes, smooth muscles and endothelium). The aim of our study was to determine the effect of 5-НT4 receptors agonist (mosapride) on nitrogen (II) oxide production and lipid peroxidation in CM and colon muscle tissue (CMT) under the conditions of experimental ulcerative colitis (UC).</abstract>

Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the regulation of the functioning of the gastrointestinal tract, including that of the colon. The response of smooth muscles, blood vessels and colon mucosa (CM) to 5-HT is realized through the activation of various types of 5-HT receptors, in particular, 5-HT4 receptors, since the latter are identified on colon cells membranes (enterocytes, smooth muscles and endothelium). The aim of our study was to determine the effect of 5-НT4 receptors agonist (mosapride) on nitrogen (II) oxide production and lipid peroxidation in CM and colon muscle tissue (CMT) under the conditions of experimental ulcerative colitis (UC).

Nitroso-oxidative stress after activation of 5-HT4 receptors under conditions of colitis in rats

Danylo Halytsky Lviv National Medical University

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Nitroso-oxidative stress after activation of 5-HT receptors under conditions of colitis in rats

Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the regulation of the functioning of the gastrointestinal tract, including that of the colon....

Nitroso-oxidative stress after activation of 5-HT₄ receptors under conditions of colitis in rats

Published Online: Jul 02, 2019

Page range: 57 - 62

Received: Apr 07, 2017

Accepted: May 12, 2018

DOI: https://doi.org/10.2478/cipms-2019-0011

Keywords
experimental colitis, mosapride, NO-synthase, lipid peroxidation, antioxidant enzymes

© 2019 Nataliya Denysenko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Nitroso-oxidative stress after activation of 5-HT4 receptors under conditions of colitis in rats

Published Online: Jul 02, 2019

Page range: 57 - 62

Received: Apr 07, 2017

Accepted: May 12, 2018

DOI: https://doi.org/10.2478/cipms-2019-0011

Keywordsexperimental colitis, mosapride, NO-synthase, lipid peroxidation, antioxidant enzymes

© 2019 Nataliya Denysenko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Nitroso-oxidative stress after activation of 5-HT₄ receptors under conditions of colitis in rats

Keywords
experimental colitis, mosapride, NO-synthase, lipid peroxidation, antioxidant enzymes