<abstract xmlns="http://www.w3.org/1999/xhtml">

<p> Cytometric analysis was performed in order to detect the expression of surface molecules CD11b and CD11/18 on lymphocytes, granulocytes, and monocytes of peripheral blood of dogs with atopic dermatitis (AD) complicated by purulent dermatitis. The percentage of peripheral blood lymphocytes with CD11b and CD11/18 was found to be significantly higher (P &lt; 0.05) in dogs with AD than in healthy dogs. The percentage of granulocytes expressing CD11b molecule was significantly lower in dogs with complicated AD compared to healthy dogs and dogs with uncomplicated AD. The expression of CD11b and CD11/18 integrin on monocytes of dogs with complicated AD depended on the severity of symptoms and was higher in dogs with deep purulent dermatitis. It was concluded that the expression of CD11b and CD11/18 integrin on leukocytes of dogs with AD depends on the stage of the disease.</p>
</abstract>

Cytometric analysis was performed in order to detect the expression of surface molecules CD11b and CD11/18 on lymphocytes, granulocytes, and monocytes of peripheral blood of dogs with atopic dermatitis (AD) complicated by purulent dermatitis. The percentage of peripheral blood lymphocytes with CD11b and CD11/18 was found to be significantly higher (P < 0.05) in dogs with AD than in healthy dogs. The percentage of granulocytes expressing CD11b molecule was significantly lower in dogs with complicated AD compared to healthy dogs and dogs with uncomplicated AD. The expression of CD11b and CD11/18 integrin on monocytes of dogs with complicated AD depended on the severity of symptoms and was higher in dogs with deep purulent dermatitis. It was concluded that the expression of CD11b and CD11/18 integrin on leukocytes of dogs with AD depends on the stage of the disease.

Assessment of CD11b and CD11/18 integrin expression on leukocytes of dogs with atopic dermatitis

Sub-Department of Clinical Diagnostics and Veterinary Dermatology, Department and Clinic of Internal Medicine, Faculty of Veterinary Medicine

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Cytometric analysis was performed in order to detect the expression of surface molecules CD11b and CD11/18 on lymphocytes, granulocytes, and monocytes of...

Assessment of CD11b and CD11/18 integrin expression on leukocytes of dogs with atopic dermatitis

Published Online: Mar 25, 2014

Page range: 99 - 103

DOI: https://doi.org/10.2478/bvip-2014-0016

Keywords
dogs, atopic dermatitis, integrins, CD11b, CD11/18, flow cytometry

© 2014 National Veterinary Research Institute in Pulawy

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Assessment of CD11b and CD11/18 integrin expression on leukocytes of dogs with atopic dermatitis

Published Online: Mar 25, 2014

Page range: 99 - 103

DOI: https://doi.org/10.2478/bvip-2014-0016

Keywordsdogs, atopic dermatitis, integrins, CD11b, CD11/18, flow cytometry

© 2014 National Veterinary Research Institute in Pulawy

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
dogs, atopic dermatitis, integrins, CD11b, CD11/18, flow cytometry