This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Sobocki P, Jonsson B, Angst J, Rehnberg C. Cost of depression in Europe. J Ment Health Policy Econ. 2006; 9(2): 87-98.SobockiPJonssonBAngstJRehnbergCCost of depression in EuropeJ Ment Health Policy Econ20069287–98Search in Google Scholar
Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: Review and meta-analysis. Am J Psychiatry. 2000; 157(10): 1552-1562.SullivanPFNealeMCKendlerKSGenetic epidemiology of major depression: Review and meta-analysisAm J Psychiatry2000157101552–156210.1176/appi.ajp.157.10.155211007705Search in Google Scholar
Kendler KS, Gatz M, Gardner CO, Pedersen NL. A Swedich national twin study of lifetime major depresssion. Am J Psychiatry. 2006; 163(1): 109-114.KendlerKSGatzMGardnerCOPedersenNLA Swedich national twin study of lifetime major depresssionAm J Psychiatry20061631109–11410.1176/appi.ajp.163.1.10916390897Search in Google Scholar
Cohen-Woods S, Craig IW, McGuffin P. The current state of play on the molecular genetics of depression. Psychol Med. 2013; 43(4): 673-687.Cohen-WoodsSCraigIWMcGuffinPThe current state of play on the molecular genetics of depressionPsychol Med2013434673–68710.1017/S003329171200128622687339Search in Google Scholar
Bosker FJ, Hartman CA, Nolte IM, Prins BP, Terpstra P, Posthuma D, et al. Poor replication of candidate genes for major depressive disorder using genome-wide association data. Mol Psychiatry. 2011; 16(5): 516-532.BoskerFJHartmanCANolteIMPrinsBPTerpstraPPosthumaDPoor replication of candidate genes for major depressive disorder using genome-wide association dataMol Psychiatry2011165516–53210.1038/mp.2010.3820351714Search in Google Scholar
Ripke S, Wray NR, Lewis CM, Hamilton SP, Weissman MM, Breen G, et al.; Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013; 18(4): 497-511.RipkeSWrayNRLewisCMHamiltonSPWeissmanMMBreenGMajor Depressive Disorder Working Group of the Psychiatric GWAS Consortium. A mega-analysis of genome-wide association studies for major depressive disorderMol Psychiatry2013184497–51110.1038/mp.2012.21383743122472876Search in Google Scholar
Shi J, Potash JB, Knowles JA, Weissman MM, Coryell W, Scheftner WA, et al. Genome-wide association study of recurrent early-onset major depressive disorder. Mol Psychiatry. 2011; 16(4): 193-201.ShiJPotashJBKnowlesJAWeissmanMMCoryellWScheftnerWAGenome-wide association study of recurrent early-onset major depressive disorderMol Psychiatry2011164193–20110.1038/mp.2009.124648640020125088Search in Google Scholar
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007; 447(7145): 661-678.Wellcome Trust Case Control ConsortiumGenome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature20074477145661–67810.1038/nature05911271928817554300Search in Google Scholar
Grover MP, Ballouz S, Mohanasundaram KA, George RA, Sherman CD, Crowley TM, et al. Identification of novel therapeutics for complex diseases from genome-wide association data. BMC Med Genomics. 2014; 7(Suppl 1): S8.GroverMPBallouzSMohanasundaramKAGeorgeRAShermanCDCrowleyTMIdentification of novel therapeutics for complex diseases from genome-wide association dataBMC Med Genomics20147Suppl 1S810.1186/1755-8794-7-S1-S8410135225077696Search in Google Scholar
Shyn SI, Hamilton SP. The genetics of major depression: moving beyond the monoamine hypothesis. Psychiatr Clin North Am. 2010; 33(1): 125-140.ShynSIHamiltonSPThe genetics of major depression: moving beyond the monoamine hypothesisPsychiatr Clin North Am2010331125–14010.1016/j.psc.2009.10.004282461820159343Search in Google Scholar
Flint J, Kendler KS. The genetics of major depression. Neuron. 2014; 81(5): 1214.FlintJKendlerKSThe genetics of major depressionNeuron2014815121410.1016/j.neuron.2014.02.033562902028898628Search in Google Scholar
Wray NR, Pergadia ML, Blackwood DH, Penninx BW, Gordon SD, Nyholt DR, et al. Genome-wide association study of major depressive disorder: New results, meta-analysis, and lessons learned. Mol Pschiatry. 2012: 17(1): 36-48.WrayNRPergadiaMLBlackwoodDHPenninxBWGordonSDNyholtDRGenome-wide association study of major depressive disorder: New results, meta-analysis, and lessons learnedMol Pschiatry201217136–4810.1038/mp.2010.109Search in Google Scholar
Kendler KS, Aggen SH, Neale MC. Evidence for multiple genetic factors underlying DSM-IV criteria for major depression. JAMA Psychiatry. 2013; 70(6): 599-607.KendlerKSAggenSHNealeMCEvidence for multiple genetic factors underlying DSM-IV criteria for major depressionJAMA Psychiatry2013706599–60710.1001/jamapsychiatry.2013.751Search in Google Scholar
Weissman MM, Bland R, Joyce PR, Newman S, Wells JE, Wittchen HU. Sex differences in rates of depression: Cross-national perspective. J Affect Disord. 1993; 39(2-3): 77-84.WeissmanMMBlandRJoycePRNewmanSWellsJEWittchenHUSex differences in rates of depression: Cross-national perspectiveJ Affect Disord1993392-377–8410.1016/0165-0327(93)90025-FSearch in Google Scholar
Verhagen M, van der Meij A, van Deurzen PA, Janzing JG, Arias-Vásquez A, Buitelaar JK, et al. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: Effects of gender and ethnicity. Mol Psychiatry. 2010; 15(3): 260-271.VerhagenMvander Meij AvanDeurzen PAJanzingJGArias-VásquezABuitelaarJKMeta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: Effects of gender and ethnicityMol Psychiatry2010153260–27110.1038/mp.2008.10918852698Search in Google Scholar
Middeldorp CM, Cath DC, Van Dyck R, Boomsma DI. The co-morbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies. Psychol Med. 2005; 35(5): 611-624.MiddeldorpCMCathDCVanDyck RBoomsmaDIThe co-morbidity of anxiety and depression in the perspective of genetic epidemiologyA review of twin and family studies. Psychol Med2005355611–62410.1017/S003329170400412XSearch in Google Scholar
Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, et al.; Cross-Disorder Group of the Psychiatric Genomics Consortium. International Inflammatory Bowel Disease Genetics Consortium (IIBDGC) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 2013; 45(9): 984-994.LeeSHRipkeSNealeBMFaraoneSVPurcellSMPerlisRHCross-Disorder Group of the Psychiatric Genomics Consortium. International Inflammatory Bowel Disease Genetics Consortium (IIBDGC) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPsNat Genet2013459984–99410.1038/ng.2711380015923933821Search in Google Scholar
McGuffin P, Rijsdijk F, Andrew M, Sham P, Katz R, Cardno A. The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Arch Gen Psychiatry. 2003; 60(5): 497-502.McGuffinPRijsdijkFAndrewMShamPKatzRCardnoAThe heritability of bipolar affective disorder and the genetic relationship to unipolar depressionArch Gen Psychiatry2003605497–50210.1001/archpsyc.60.5.49712742871Search in Google Scholar
Demirkan A, Penninx BW, Hek K, Wray NR, Amin N, Aulchenko YS, et al. Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Mol Psychiatry. 2011; 16(7): 773-783.DemirkanAPenninxBWHekKWrayNRAminNAulchenkoYSGenetic risk profiles for depression and anxiety in adult and elderly cohortsMol Psychiatry2011167773–78310.1038/mp.2010.65314296420567237Search in Google Scholar
Weissman MM, Wickramaratne P, Nomura Y, Warner V, Pilowsky D, Verdeli H. Offspring of depressed parents: 20 years later. Am J Psychiatry. 2006; 163(6): 1001-1008.WeissmanMMWickramaratnePNomuraYWarnerVPilowskyDVerdeliHOffspring of depressed parents: 20 years laterAm J Psychiatry200616361001–100810.1176/ajp.2006.163.6.100116741200Search in Google Scholar
Weissman MM, Wickramaratne P, Nomura Y, Warner V, Verdeli H, Pilowsky DJ, et al. Families at high and low risk for depression: A 3-generation study. Arch Gen Psychiatry. 2005; 62(1): 29-36.WeissmanMMWickramaratnePNomuraYWarnerVVerdeliHPilowskyDJFamilies at high and low risk for depression: A 3-generation studyArch Gen Psychiatry200562129–3610.1001/archpsyc.62.1.2915630070Search in Google Scholar
Levinson DF, Evgrafov OV, Knowles JA, Potash JB, Weissman MM, Scheftner WA, et al. Genetics of recurrent early-onset major depression (GenRED): Significant linkage on chromosome 15q25-q26 after fine mapping with single nucleotide polymorphism markers. Am J Psychiatry. 2007; 164(2): 259-264.LevinsonDFEvgrafovOVKnowlesJAPotashJBWeissmanMMScheftnerWAGenetics of recurrent early-onset major depression (GenRED): Significant linkage on chromosome 15q25-q26 after fine mapping with single nucleotide polymorphism markersAm J Psychiatry20071642259–26410.1176/ajp.2007.164.2.25917267788Search in Google Scholar
Zubenko GS, Maher B, Hughes HB 3rd, Zubenko WN, Stiffler JS, Kaplan BB, et al. Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression. Am J Med Genet B Neuropsychiatr Genet. 2003; 123B(1): 1-18.ZubenkoGSMaherBHughesHB 3rdZubenkoWNStifflerJSKaplanBBGenome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depressionAm J Med Genet B Neuropsychiatr Genet2003123B11–1810.1002/ajmg.b.2007314582139Search in Google Scholar
Lubke GH, Hottenga JJ, Walters R, Laurin C, de Geus EJ, Willemsen G, et al. Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms. Biol Psychiatry. 2012; 72(8): 707-709.LubkeGHHottengaJJWaltersRLaurinCdeGeus EJWillemsenGEstimating the genetic variance of major depressive disorder due to all single nucleotide polymorphismsBiol Psychiatry2012728707–70910.1016/j.biopsych.2012.03.011340425022520966Search in Google Scholar
Hodžić A, Ristanović M, Zorn B, Tulić C, Maver A, Novaković I, et al. Genetic variation in circadian rhythm genes CLOCK and ARNTL as risk factor for male infertility. PLoS One. 2013; 8(3): e59220.HodžićARistanovićMZornBTulićCMaverANovakovićIGenetic variation in circadian rhythm genes CLOCK and ARNTL as risk factor for male infertilityPLoS One201383e5922010.1371/journal.pone.0059220360106223527142Search in Google Scholar
Tomoda A, Nishitani S, Matsuura N, Fujisawa TX, Kawatani J, Toyohisa D, et al. No interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescents. BMC Psychiatry. 2013; 13: 134.TomodaANishitaniSMatsuuraNFujisawaTXKawataniJToyohisaDNo interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescentsBMC Psychiatry20131313410.1186/1471-244X-13-134365380623663729Search in Google Scholar
Antypa N, Drago A, Serretti A. The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes. Neurosci Biobehav Rev. 2013; 37(8): 1597-1610.AntypaNDragoASerrettiAThe role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypesNeurosci Biobehav Rev20133781597–161010.1016/j.neubiorev.2013.06.00623792050Search in Google Scholar
Massat I, Souery D, Del-Favero J, Nothen M, Black-wood D, Muir W, et al. Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study. Mol Psychiatry. 2005; 10(6): 598-605.MassatISoueryDDel-FaveroJNothenMBlack-woodDMuirWAssociation between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association studyMol Psychiatry2005106598–60510.1038/sj.mp.400161515583702Search in Google Scholar
Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science. 2003; 301(5631): 386-389.CaspiASugdenKMoffittTETaylorACraigIWHarringtonHInfluence of life stress on depression: Moderation by a polymorphism in the 5-HTT geneScience20033015631386–38910.1126/science.108396812869766Search in Google Scholar
Fergusson DM, Horwood LJ, Miller AL, Kennedy MA. Life stress, 5-HTTLPR and mental disorder: Findings from a 30-year longitudinal study. Br J Psychiatry. 2011: 198(2): 129-135.FergussonDMHorwoodLJMillerALKennedyMA. Life stress5-HTTLPR and mental disorder: Findings from a 30-year longitudinal studyBr J Psychiatry20111982129–13510.1192/bjp.bp.110.085993303165321282783Search in Google Scholar
López-León S, Janssens AC, González-Zuloeta Ladd AM, Del-Favero J, Claes SJ, Oostra BA, et al. Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry. 2008; 13(8): 772-785.López-LeónSJanssensACGonzález-ZuloetaLadd AMDel-FaveroJClaesSJOostraBAMeta-analyses of genetic studies on major depressive disorderMol Psychiatry2008138772–78510.1038/sj.mp.400208817938638Search in Google Scholar
Sullivan PF, de Geus EJ, Willemsen G, James MR, Smit JH, Zandbelt T, et al. Genome-wide association for major depressive disorder: A possible role for the presyn-aptic protein piccolo. Mol Psychiatry. 2009; 14(4): 359-375.SullivanPFdeGeus EJWillemsenGJamesMRSmitJHZandbeltTGenome-wide association for major depressive disorder: A possible role for the presyn-aptic protein piccoloMol Psychiatry2009144359–37510.1038/mp.2008.125271772619065144Search in Google Scholar
Hek K, Mulder CL, Luijendijk HJ, van Duijn CM, Hofman A, Uitterlinden AG, Tiemeier H. The PCLO gene and depressive disorders: replication in a population-based study. Hum Mol Genet. 2010; 19(4): 731-734.HekKMulderCLLuijendijkHJvanDuijn CMHofmanAUitterlindenAGTiemeierHThe PCLO gene and depressive disorders: replication in a population-based studyHum Mol Genet2010194731–73410.1093/hmg/ddp52919942622Search in Google Scholar
Minelli A, Scassellati C, Cloninger CR, Tessari E, Bortolomasi M, Bonvicini C, et al. PCLO gene: Its role in vulnerability to major depressive disorder. J Affect Disord. 2012; 139(3): 250-255.MinelliAScassellatiCCloningerCRTessariEBortolomasiMBonviciniCPCLO gene: Its role in vulnerability to major depressive disorderJ Affect Disord20121393250–25510.1016/j.jad.2012.01.02822386049Search in Google Scholar
Ustün TB, Ayuso-Mateos JL, Chatterji S, Mathers C, Murray CJ. Global burden of depressive disorders in the year 2000. Br J Psychiatry. 2004; 184: 386-392.UstünTBAyuso-MateosJLChatterjiSMathersCMurrayCJGlobal burden of depressive disorders in the year 2000Br J Psychiatry2004184386–39210.1192/bjp.184.5.38615123501Search in Google Scholar
Collins PY, Patel V, Joestl SS, March D, Insel TR, Daar AS, et al.; Scientific Advisory Board and the Executive Committee of the Grand Challenges on Global Mental Health. Grand challenges in global mental health. Nature. 2011; 475(7354): 27-30.CollinsPYPatelVJoestlSSMarchDInselTRDaarASScientific Advisory Board and the Executive Committee of the Grand Challenges on Global Mental Health. Grand challenges in global mental healthNature2011475735427–3010.1038/475027a317380421734685Search in Google Scholar
Lacerda-Pinheiro SF, Pinheiro Junior RF, Pereira de Lima MA, Lima da Silva CG, Santos MD, Teixeira Júnior AG, et al. Are there depression and anxiety genetic markers and mutations? A systematic review. J Affect Disord. 2014; 168: 387-398Lacerda-PinheiroSFPinheiroJunior RFPereirade Lima MALimada Silva CGSantosMDTeixeiraJúnior AGAre there depression and anxiety genetic markers and mutations? A systematic reviewJ Affect Disord2014168387–39810.1016/j.jad.2014.07.01625106036Search in Google Scholar
Levinson DF. The genetics of depression: A review. Biol Psychiatry. 2006; 60(2): 84-92.LevinsonDFThe genetics of depression: A reviewBiol Psychiatry200660284–9210.1016/j.biopsych.2005.08.02416300747Search in Google Scholar
