A Novel Angiogenesis Inhibitor Bevacizumab Induces Apoptosis in the Rat Endometriosis Model

1. Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am. 1997; 24(2): 235-258. 2 D’Hooghe TM, Debrock S, Hill JA, Meuleman C. Endometriosis and subfertility: Is the relationship resolved? Semin Reprod Med 2003; 21(2): 243-254.Search in Google Scholar

3. Vinatier D, Orazi G, Cosson M, Dufour P. Theories of endometriosis. Eur J Obstet Gynecol Reprod Biol. 2001; 96(1): 21-34.10.1016/S0301-2115(00)00405-XSearch in Google Scholar

4. McLaren J. Vascular endothelial growth factor and endometriotic angiogenesis. Hum Reprod Update. 2000; 6(1): 45-55.10.1093/humupd/6.1.45Search in Google Scholar

5. Grothey A, Ellis LM. Targeting angiogenesis driven by vascular endothelial growth factors using antibody-based therapies. Cancer J. 2008; 14(3):170-177.10.1097/PPO.0b013e318178d9deSearch in Google Scholar

6. Selvakumaran M, Yao KS, Feldman MD, O’Dwyer PJ. Antitumor effect of the angiogenesis inhibitor bevacizumab is dependent on susceptibility of tumors to hypoxia-induced apoptosis. Biochem Pharmacol. 2008; 75(3): 627-638.10.1016/j.bcp.2007.09.029Search in Google Scholar

7. Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 1998; 394(6692): 485-490.10.1038/28867Search in Google Scholar

8. Shaheen RM, Davis DW, Liu W, Zebrowski BK, Wilson MR, Bucana CD, et al. Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Cancer Res. 1999; 59(21): 5412-5416.Search in Google Scholar

9. Gebel HM, Braun DP, Tambur A, Frame D, Rana N, Dmowski WP. Spontaneous apoptosis of endometrial tissue is impaired in women with endometriosis. Fertil Steril. 1998; 69(6): 1042-1047.10.1016/S0015-0282(98)00073-9Search in Google Scholar

10. Safaeian L, Abed A, Vaseghi G. The role of Bcl-2 family proteins in pulmonary fibrosis. Eur J Pharmacol. 2014. pii: S0014-2999(14)00566-4. doi: 10.1016/j.ejphar. 2014.07.029.Search in Google Scholar

11. Tesone M, Bilotas M, Barañao RI, Meresman G. The role of GnRH analogues in endometriosisassociated apoptosis and angiogenesis. Gynecol Obstet Invest. 2008; 66(Suppl 1): 10-18.10.1159/000148026Search in Google Scholar

12. Vernon MW, Wilson EA. Studies on the surgical induction of endometriosis in the rat. Fertil Steril. 1985; 44(5): 684-694.10.1016/S0015-0282(16)48988-0Search in Google Scholar

13. Linsky CB, Diamond MP, Cunningham T, Constantine B, De-Cherney AH, diZerega GS. Adhesion reduction in a rabbit uterine horn model using an absorbable barrier TC-7. J Reprod Med. 1987; 32(1): 17-20.Search in Google Scholar

14. Keenan JA, Williams-Boyce PK, Massey PJ, Chen TT, Caudle MR, Bukovsky A. Regression of endometrial explants in a rat model of endometriosis treated with the immune modulators loxoribine and levamisole. Fertil Steril. 1999; 72(1): 135-141.10.1016/S0015-0282(99)00157-0Search in Google Scholar

15. Crosignani P, Olive D, Bergqvist A, Luciano A. Advances in the management of endometriosis: An update for clinicians. Hum Reprod Update. 2006; 12(2): 179-189.10.1093/humupd/dmi049Search in Google Scholar

16. Matsuzaki S, Canis M, Murakami T, Dechelotte P, Bruhat MA, Okamura K. Immunohistochemical analysis of the role of angiogenic status in the vasculature of peritoneal endometriosis. Fertil Steril. 2001; 76(4): 712-716.10.1016/S0015-0282(01)02003-9Search in Google Scholar

17. Mihalyi A, Simsa P, Mutinda KC, Meuleman C, Mwenda JM, D’Hooghe TM. Emerging drugs in endometriosis. Expert Opin Emerg Drugs. 2006; 11(3): 503-524.10.1517/14728214.11.3.503Search in Google Scholar

18. Rice VM. Conventional medical therapies for endometriosis. Ann N Y Acad Sci. 2002; 955: 343-352.10.1111/j.1749-6632.2002.tb02795.xSearch in Google Scholar

19. Child TJ, Tan SL. Endometriosis: Aetiology, pathogenesis and treatment. Drugs. 2001; 61(12): 1735-1750.10.2165/00003495-200161120-00005Search in Google Scholar

20. Groothuis PG, Nap AW, Winterhager E, Grümmer R. Vascular development in endometriosis. Angiogenesis. 2005; 8(2): 147-156.10.1007/s10456-005-9005-xSearch in Google Scholar

21. Donnez J, Smoes P, Gillerot S, Casanas-Roux F, Nisolle M. Vascular endothelial growth factor (VEGF) in endometriosis. Hum Reprod. 1998; 13(6): 1686-1690.10.1093/humrep/13.6.1686Search in Google Scholar

22. Taylor RN, Lebovic DI, Mueller MD. Angiogenic factors in endometriosis. Ann N Y Acad Sci. 2002; 955: 89-100.10.1111/j.1749-6632.2002.tb02769.xSearch in Google Scholar

23. Nisolle M, Casanas-Roux F, Anaf V, Mine JM, Donnez J. Morphometric study of the stromal vascularization in peritoneal endometriosis. Fertil Steril. 1993; 59(3):681-684.10.1016/S0015-0282(16)55823-3Search in Google Scholar

24. Matsuzaki S, Canis M, Murakami T, Dechelotte P, Bruhat MA, Okamura K. Immunohistochemical analysis of the role of angiogenic status in the vasculature of peritoneal endometriosis. Fertil Steril. 2001; 76(4):712-716.10.1016/S0015-0282(01)02003-9Search in Google Scholar

25. Hull ML, Charnock-Jones DS, Chan CL, Bruner- Tran KL, Osteen KG, Tom BD, et al. Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab. 2003; 88(6): 2889-2899.10.1210/jc.2002-021912Search in Google Scholar

26. Dabrosin C, Gyorffy S, Margetts P, Ross C, Gauldie J. Therapeutic effect of angiostatin gene transfer in a murine model of endometriosis. Am J Pathol. 2002; 161(3): 909-918.10.1016/S0002-9440(10)64251-4Search in Google Scholar

27. Nap AW, Griffioen AW, Dunselman GA, Bouma- Ter Steege JC, Thijssen VL, Evers JL, et al. Antiangiogenesis therapy for endometriosis. J Clin Endocrinol Metab. 2004; 89(3): 1089-1095.10.1210/jc.2003-031406Search in Google Scholar

28. Becker CM, Sampson DA, Rupnick MA, Rohan RM, Efstathiou JA, Short SM, et al. Endostatin inhibits the growth of endometriotic lesions but does not affect fertility. Fertil Steril. 2005; 84(Suppl 2): 1144-1155.10.1016/j.fertnstert.2005.04.040Search in Google Scholar

29. Laschke MW, Elitzsch A, Vollmar B, Vajkoczy P, Menger MD. Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions. Hum Reprod. 2006; 21(1): 262-268.10.1093/humrep/dei308Search in Google Scholar

30. Novella-Maestre E, Carda C, Noguera I, Ruiz- Saurí A, García-Velasco JA, Simón C, et al. Dopamine agonist administration causes a reduction in endometrial implants through modulation of angiogenesis in experimentally induced endometriosis. Hum Reprod. 2009; 24(5): 1025-1035.10.1093/humrep/den499Search in Google Scholar

31. Ricci AG, Olivares CN, Bilotas MA, Meresman GF, Barañao RI. Effect of vascular endothelial growth factor inhibition on endometrial implant development in a murine model of endometriosis. Reprod Sci. 2011; 18(7): 614-622.10.1177/1933719110395406Search in Google Scholar

32. Meresman GF, Bilotas MA, Lombardi E, Tesone M, Sueldo C, Baranao R. Effect of GnRH analogues on apoptosis and release of interleukin-1β and vascular endothelial growth factor in endometrial cell cultures from patients with endometriosis. Hum Reprod. 2003; 18(9): 1767-1771.10.1093/humrep/deg356Search in Google Scholar

33. Bilotas M, Barañao RI, Buquet R, Sueldo C, Tesone M, Meresman GF. Effect of GnRH analogues on apoptosis and expression of Bcl-2, Bax, Fas and FasL proteins in endometrial epithelial cell cultures from patients with endometriosis and controls. Hum Reprod. 2007; 22(3): 644-653.10.1093/humrep/del423Search in Google Scholar

34. Meresman GF, Bilotas M, Buquet RA, Barañao RI, Sueldo C, Tesone M. Gonadotropin-releasing hormone agonist induces apoptosis and reduces cell proliferation in eutopic endometrial cultures from women with endometriosis. Fertil Steril. 2003; 80(2): 702-707.10.1016/S0015-0282(03)00769-6Search in Google Scholar

35. Imai A, Takagi A, Tamaya T. Gonadotropin-releasing hormone analog repairs reduced endometrial cell apoptosis in endometriosis in vitro. Am J Obstet Gynecol. 2000; 182(5): 1142-1146.10.1067/mob.2000.10480410819849Search in Google Scholar

36. Khan KN, Kitajima M, Hiraki K, Fujishita A, Sekine I, Ishimaru T, et al. Changes in tissue inflammation, angiogenesis and apoptosis in endometriosis, adenomyosis and uterine myoma after GnRH agonist therapy. Hum Reprod. 2010; 25(3): 642-653.10.1093/humrep/dep43720008888Search in Google Scholar

37. Moraloğlu O, Işik H, Kiliç S, Sahin U, Caydere M, Ustün H, et al. Effect of bevacizumab on postoperative adhesion formation in a rat uterine horn adhesion model and the correlation with vascular endothelial growth factor and Ki-67 immunopositivity. Fertil Steril. 2011; 95(8): 2638-2641.10.1016/j.fertnstert.2011.02.00521388619Search in Google Scholar

38. Shord SS, Bressler LR, Tierney LA, Cuellar S, George A. Understanding and managing the possible adverse effects associated with bevacizumab. Am J Health Syst Pharm. 2009; 66(11): 999-101. 10.2146/ajhp08045519451611Search in Google Scholar