In this work, computational fluid dynamics (CFD) was used to investigate the effect of the bottom shape on the flow field and mixing characteristics in an agitated vessel stirred by six-pitched blade turbine (PBT6). The simulation was based on the resolution of the Navier-Stokes equations using standard k-ε turbulence model. Hydrodynamic behavior of the stirred vessel with four types of bottom shapes was investigated, a flat bottom and three different semi-elliptical bottoms. The results show reasonably satisfactory agreement with the experimental data. The CFD simulation also showed that the semi-elliptical bottom shapes had a significant influence on the velocity profiles and on the turbulent kinetic energy distributions of the local flow generated at the bottom region of the vessel.