<abstract xmlns="http://www.w3.org/1999/xhtml"><p>In this paper, we introduce a three-dimensional lattice-based computational model in which every lattice point can be occupied by an agent of various types (e.g. cancer cell, blood vessel cell or extracellular matrix). The behavior of agents can be associated to different chemical compounds that obey mass-transfer laws such as diffusion and decay in the surrounding environment. Furthermore, agents are also able to produce and consume chemical compounds. After a detailed description, the capabilities of the model are demonstrated by presenting and discussing a simulation of a biological experiment available in the literature.</p></abstract>

In this paper, we introduce a three-dimensional lattice-based computational model in which every lattice point can be occupied by an agent of various types (e.g. cancer cell, blood vessel cell or extracellular matrix). The behavior of agents can be associated to different chemical compounds that obey mass-transfer laws such as diffusion and decay in the surrounding environment. Furthermore, agents are also able to produce and consume chemical compounds. After a detailed description, the capabilities of the model are demonstrated by presenting and discussing a simulation of a biological experiment available in the literature.

Simulating Solid Tumors with a Microenvironment-Coupled Agent-Based Computational Model

Doctoral School of Applied Informatics and Applied Mathematics

Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences

Acta Universitatis Sapientiae, Electrical and Mechanical Engineering

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

In this paper, we introduce a three-dimensional lattice-based computational model in which every lattice point can be occupied by an agent of various types...

Simulating Solid Tumors with a Microenvironment-Coupled Agent-Based Computational Model

Published Online: Feb 01, 2019

Page range: 90 - 101

Received: Jul 25, 2018

Accepted: Dec 15, 2018

DOI: https://doi.org/10.2478/auseme-2018-0006

Keywords
Agent-based model, On-lattice computational model, Tumor growth characteristics, Hypoxia, Necrotic core formation

© 2018 Dániel Kiss et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Simulating Solid Tumors with a Microenvironment-Coupled Agent-Based Computational Model

Published Online: Feb 01, 2019

Page range: 90 - 101

Received: Jul 25, 2018

Accepted: Dec 15, 2018

DOI: https://doi.org/10.2478/auseme-2018-0006

KeywordsAgent-based model, On-lattice computational model, Tumor growth characteristics, Hypoxia, Necrotic core formation

© 2018 Dániel Kiss et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Agent-based model, On-lattice computational model, Tumor growth characteristics, Hypoxia, Necrotic core formation