<abstract xmlns="http://www.w3.org/1999/xhtml">Three manganese complexes of the antibiotic doxycyline viz.: manganese doxycyline, [MnDox2]Cl2‧2H2O (1), and manganese doxycyline with bipyridine, [MnDox2(bpy)]Cl2‧8H2O (2), and phenanthroline, [MnDox2(phen)]Cl2‧8H2O (3), as the ancillary ligand were synthesized and characterized by FT-IR, elemental analysis and electrospray mass spectroscopy. The three complexes show good solubility in DMF and DMSO. Data obtained from spectroscopic techniques used show that doxycycline coordinates to the central manganese atom through the oxygen of the amide group and the carbonyl oxygen atom of ring A while bipyridine/phenanthroline coordinates through the two diimine nitrogen atoms. The stoichiometry of manganese-doxycycline is 1:2 and octahedral geometry is the preferred coordination in all the complexes.</abstract>

Three manganese complexes of the antibiotic doxycyline viz.: manganese doxycyline, [MnDox2]Cl2‧2H2O (1), and manganese doxycyline with bipyridine, [MnDox2(bpy)]Cl2‧8H2O (2), and phenanthroline, [MnDox2(phen)]Cl2‧8H2O (3), as the ancillary ligand were synthesized and characterized by FT-IR, elemental analysis and electrospray mass spectroscopy. The three complexes show good solubility in DMF and DMSO. Data obtained from spectroscopic techniques used show that doxycycline coordinates to the central manganese atom through the oxygen of the amide group and the carbonyl oxygen atom of ring A while bipyridine/phenanthroline coordinates through the two diimine nitrogen atoms. The stoichiometry of manganese-doxycycline is 1:2 and octahedral geometry is the preferred coordination in all the complexes.

Synthesis, characterization and antibacterial susceptibility testing of manganese complexes of doxycyline with bipyridine and phenanthroline

Ovidius University Annals of Chemistry

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Three manganese complexes of the antibiotic doxycyline viz.: manganese doxycyline, [MnDox2]Cl2‧2H2O (1), and manganese doxycyline with bipyridine,...

Synthesis, characterization and antibacterial susceptibility testing of manganese complexes of doxycyline with bipyridine and phenanthroline

Published Online: Jul 15, 2019

Page range: 70 - 74

Received: Apr 08, 2019

Accepted: Jul 04, 2019

DOI: https://doi.org/10.2478/auoc-2019-0013

Keywords
manganese, doxycycline, coordination, antibacterial, synthesis

© 2019 Joshua A. Obaleye et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesis, characterization and antibacterial susceptibility testing of manganese complexes of doxycyline with bipyridine and phenanthroline

Published Online: Jul 15, 2019

Page range: 70 - 74

Received: Apr 08, 2019

Accepted: Jul 04, 2019

DOI: https://doi.org/10.2478/auoc-2019-0013

Keywordsmanganese, doxycycline, coordination, antibacterial, synthesis

© 2019 Joshua A. Obaleye et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
manganese, doxycycline, coordination, antibacterial, synthesis