<abstract xmlns="http://www.w3.org/1999/xhtml">The purpose of the work was to evaluate the Fe-chelating activity of freeze drying assisted ultrasonicated hydroethanolic leaf extracts of Conocarpus lancifolius Engl. along with 1H-NMR based classification of metabolites in most active extract. The finding revealed that 60% ethanolic extract was the most active fraction regarding Fe-chelating activity with value of 75.4 ± 0.6% followed by 80% ethanolic extract having chelating value of 69.24±1.02%. The least Fe-chelating activity was exhibited by aqueous extract. The statistical analysis revealed that the Fe-chelating activity by 60% ethanolic extract was significantly higher than other fractions except EDTA which was used as standard chelating agent. The 1HNMR technique predicted the presence of aromatic secondary metabolites of polyphenolic origin due to numerous peaks in respective regions. The peaks in carbohydrate and organic acid regions were also observed. The research outcomes suggested that C. lancifolius may be workable choice to move further for the development of cure and management practices for iron load based oxidative stress oriented diseases including diabetes mellitus type II.</abstract>

The purpose of the work was to evaluate the Fe-chelating activity of freeze drying assisted ultrasonicated hydroethanolic leaf extracts of Conocarpus lancifolius Engl. along with 1H-NMR based classification of metabolites in most active extract. The finding revealed that 60% ethanolic extract was the most active fraction regarding Fe-chelating activity with value of 75.4 ± 0.6% followed by 80% ethanolic extract having chelating value of 69.24±1.02%. The least Fe-chelating activity was exhibited by aqueous extract. The statistical analysis revealed that the Fe-chelating activity by 60% ethanolic extract was significantly higher than other fractions except EDTA which was used as standard chelating agent. The 1HNMR technique predicted the presence of aromatic secondary metabolites of polyphenolic origin due to numerous peaks in respective regions. The peaks in carbohydrate and organic acid regions were also observed. The research outcomes suggested that C. lancifolius may be workable choice to move further for the development of cure and management practices for iron load based oxidative stress oriented diseases including diabetes mellitus type II.

Fe-Chelating Activity of <italic>Conocarpus lancifolius</italic> Engl. Leaf Extracts and 1H-NMR Based Metabolite’s classification

Balochistan University of Information Technology

Acta Scientifica Naturalis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Fe-Chelating Activity of  Engl. Leaf Extracts and H-NMR Based Metabolite’s classification

The purpose of the work was to evaluate the Fe-chelating activity of freeze drying assisted ultrasonicated hydroethanolic leaf extracts of Conocarpus...

Fe-Chelating Activity of Conocarpus lancifolius Engl. Leaf Extracts and ¹H-NMR Based Metabolite’s classification

Published Online: Apr 18, 2020

Page range: 1 - 7

DOI: https://doi.org/10.2478/asn-2020-0002

Keywords
ultrasonication, Fe-chelating activity, H-NMR, metabolite prediction

© 2020 Syed Ali Raza et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Fe-Chelating Activity of Conocarpus lancifolius Engl. Leaf Extracts and 1H-NMR Based Metabolite’s classification

Published Online: Apr 18, 2020

Page range: 1 - 7

DOI: https://doi.org/10.2478/asn-2020-0002

Keywordsultrasonication, Fe-chelating activity, H-NMR, metabolite prediction

© 2020 Syed Ali Raza et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Fe-Chelating Activity of Conocarpus lancifolius Engl. Leaf Extracts and ¹H-NMR Based Metabolite’s classification

Keywords
ultrasonication, Fe-chelating activity, H-NMR, metabolite prediction