<abstract xmlns="http://www.w3.org/1999/xhtml">Interest in nanomaterials, especially metal oxides, in the fight against resistant and constantly changing bacterial strains, is more and more expressed. Their very high reactivity, resulting from their large surface area, promoted them to the rank of potential successors of antibiotics.Our work consisted of the synthesis of zinc oxide (ZnO) and copper oxide (CuO) in the nanoparticle state and the study of their bactericidal effect on various Gram-negative and Gram-positive bacterial strains.The nanoparticles of metal oxides have been synthesized by sol-gel method. Qualitative analysis and characterization by UV / Visible and infrared spectrophotometry and X-ray diffraction confirmed that the synthetic products are crystalline. The application of the Scherrer equation allows to determine the size of the two metal oxides, namely: 76.94 nm for ZnO and 24.86 nm for CuO.The bactericidal effect of ZnO and CuO nanoparticles was tested on Gram-positive bacteria (Staphylococcus aureus, Staphylococcus hominis, Staphylococcus haemolyticus, Enterococcus facials) and Gram-negative bacteria (Escherichia coli, Schigella, Klepsiella pneumoniae and Pseudomonas aeruginosa). The results indicate that the tested metal oxides nanoparticles have an effect that varies depending on bacterial species. Indeed, Gram-positive bacteria show greater sensitivity to ZnO nanoparticles whereas Gram-negative bacteria are more sensitive to CuO nanoparticles.</abstract>

Interest in nanomaterials, especially metal oxides, in the fight against resistant and constantly changing bacterial strains, is more and more expressed. Their very high reactivity, resulting from their large surface area, promoted them to the rank of potential successors of antibiotics.Our work consisted of the synthesis of zinc oxide (ZnO) and copper oxide (CuO) in the nanoparticle state and the study of their bactericidal effect on various Gram-negative and Gram-positive bacterial strains.The nanoparticles of metal oxides have been synthesized by sol-gel method. Qualitative analysis and characterization by UV / Visible and infrared spectrophotometry and X-ray diffraction confirmed that the synthetic products are crystalline. The application of the Scherrer equation allows to determine the size of the two metal oxides, namely: 76.94 nm for ZnO and 24.86 nm for CuO.The bactericidal effect of ZnO and CuO nanoparticles was tested on Gram-positive bacteria (Staphylococcus aureus, Staphylococcus hominis, Staphylococcus haemolyticus, Enterococcus facials) and Gram-negative bacteria (Escherichia coli, Schigella, Klepsiella pneumoniae and Pseudomonas aeruginosa). The results indicate that the tested metal oxides nanoparticles have an effect that varies depending on bacterial species. Indeed, Gram-positive bacteria show greater sensitivity to ZnO nanoparticles whereas Gram-negative bacteria are more sensitive to CuO nanoparticles.

Comparative Study of the Bacteriological Activity of Zinc Oxide and Copper Oxide Nanoparticles

Department of Pharmacy, Faculty of Medicine

Modeling and Optimization of Chemical Processes Department of Process Engineering

Laboratory of Natural Resources and Management of Sensitive Environments

Laboratoire d′Innovation en construction

Acta Scientifica Naturalis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Interest in nanomaterials, especially metal oxides, in the fight against resistant and constantly changing bacterial strains, is more and more expressed. Their...

Comparative Study of the Bacteriological Activity of Zinc Oxide and Copper Oxide Nanoparticles

Published Online: May 27, 2019

Page range: 63 - 72

Received: Mar 01, 2019

Accepted: Apr 01, 2019

DOI: https://doi.org/10.2478/asn-2019-0009

Keywords
Nanoparticles, ZnO, CuO, sol-gel method, bactericidal effect

© 2019 Abdelali Merah et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Comparative Study of the Bacteriological Activity of Zinc Oxide and Copper Oxide Nanoparticles

Published Online: May 27, 2019

Page range: 63 - 72

Received: Mar 01, 2019

Accepted: Apr 01, 2019

DOI: https://doi.org/10.2478/asn-2019-0009

KeywordsNanoparticles, ZnO, CuO, sol-gel method, bactericidal effect

© 2019 Abdelali Merah et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Nanoparticles, ZnO, CuO, sol-gel method, bactericidal effect