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Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018, 68(6):394-424.Search in Google Scholar
Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G, Bettio M, Gavin A, Visser O, Bray F. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018 Eur J Cancer, 2018, 103: 356-387.Search in Google Scholar
Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival and risk factors. Prz Gastroenterol, 2019, 14(2):89-103.Search in Google Scholar
Zauber P, Huang J, Sabbath-Solitare M, Marotta S. Similarities of molecular genetic changes in synchronous and metachronous colorectal cancers are limited and related to the cancers proximities to each other. J Mol Diagn, 2013, 15(5):652-60.Search in Google Scholar
Warren S, Gates O. Multiple primary malignant tumors: a survey of the literature and a statistical study. Am J Cancer, 1932, 16:1358-1414.Search in Google Scholar
Hayakumo T, Cho E, Nakajima M, Kato G, Kawai K, Azuma T. Point mutations in the c-K-ras 2 gene in multiple colorectal carcinomas. J Gastroenterol Hepatol, 1995, 10(1):70-5.Search in Google Scholar
Brînzan C, Aşchie M, Cozaru G, Dumitru E, Mitroi A. The diagnostic value of miR-92a, −143, and −145 expression levels in patients with colorectal adenocarcinoma from Romania. Medicine (Baltimore), 2020, 99(35):e21895.Search in Google Scholar
Avonts-Avontis K. Multiple colorectal tumors. Surg Clin North Am, 1987, 66:857-65.Search in Google Scholar
Lasser A. Synchronous primary adenocarcinomas of the colon and rectum. Dis Colon Rectum, 1978, 21(1):20-2.Search in Google Scholar
Chen HS, Sheen-Chen SM. Synchronous and “early” metachronous colorectal adenocarcinoma: analysis of prognosis and current trends. Dis Colon Rectum, 2000, 43(8):1093-9.Search in Google Scholar
Oya M, Takahashi S, Okuyama T, Yamaguchi M, Ueda Y. Synchronous colorectal carcinoma: clinico-pathological features and prognosis. Jpn J Clin Oncol, 2003, 33(1):38-43.Search in Google Scholar
Papadopoulos V, Michalopoulos A, Basdanis G, Papapolychroniadis K, Paramythiotis D, Fotiadis P, Berovalis P, Harlaftis N. Synchronous and metachronous colorectal carcinoma. Tech Coloproctol, 2004, 8 Suppl 1:s97-s100.Search in Google Scholar
Spizzirri A, Coccetta M, Cirocchi R, La Mura F, Napolitano V, Bravetti M, Giuliani D, De Sol A, Pressi E, Trastulli S, Di Patrizi MS, Avenia N, Sciannameo F. Synchronous colorectal neoplasias: our experience about laparoscopic-TEM combined treatment. World J Surg Oncol, 2010, 8:105.Search in Google Scholar
Fukatsu H, Kato J, Nasu JI, Kawamoto H, Okada H, Yamamoto H, Sakaguchi K, Shiratori Y. Clinical characteristics of synchronous colorectal cancer are different according to tumour location. Dig Liver Dis, 2007, 39(1):40-6.Search in Google Scholar
Latournerie M, Jooste V, Cottet V, Lepage C, Faivre J, Bouvier AM. Epidemiology and prognosis of synchronous colorectal cancers. Br J Surg, 2008, 95(12):1528-33.Search in Google Scholar
Nosho K, Kure S, Irahara N, Shima K, Baba Y, Spiegelman D, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S. A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers. Gastroenterology, 2009, 137(5):1609-20.e1-3.Search in Google Scholar
He W, Zheng C, Wang Y, Dan J, Zhu M, Wei M, Wang J, Wang Z. Prognosis of synchronous colorectal carcinoma compared to solitary colorectal carcinoma: a matched pair analysis. Eur J Gastroenterol Hepatol, 2019, 31(12):1489-1495.Search in Google Scholar
Brambilla E, Sgarioni AC, Finger G, Sartori G, Cimarosti MJ. Incidence and epidemiological features of synchronous and metachronous colorectal cancer. J Coloproctol, 2013, 33(2):58-61.Search in Google Scholar
Li S, Zhu K, Yu W, Wang Y, Wang T, Guo S, Teng G, Guo J. Synchronous neoplastic lesions in referred patients with colorectal cancer: a retrospective cohort study. Cancer Manag Res, 2019, 26(11):9951-9959.Search in Google Scholar
Greenstein AJ, Slater G, Heimann TM, Sachar DB, Aufses AH Jr. A comparison of multiple synchronous colorectal cancer in ulcerative colitis, familial polyposis coli, and de novo cancer. Ann Surg, 1986, 203(2):123-8.Search in Google Scholar
Liu X, Goldblum JR, Zhao Z, Landau M, Heald B, Pai R, Lin J. Distinct clinicohistologic features of inflammatory bowel disease-associated colorectal adenocarcinoma: in comparison with sporadic microsatellite-stable and Lynch syndrome-related colorectal adenocarcinoma. Am J Surg Pathol, 2012, 36(8):1228-33.Search in Google Scholar
Kiran RP, Khoury W, Church JM, Lavery IC, Fazio VW, Remzi FH. Colorectal cancer complicating inflammatory bowel disease: similarities and differences between Crohn’s and ulcerative colitis based on three decades of experience. Ann Surg, 2010, 252(2):330-5.Search in Google Scholar
Yang J, Peng JY, Chen W. Synchronous colorectal cancers: a review of clinical features, diagnosis, treatment, and prognosis. Dig Surg, 2011, 28(5-6):379-85.Search in Google Scholar
Fante R, Roncucci L, Di GregorioC, Tamassia MG, Losi L, Benatti P, Pedroni M, Percesepe A, De Pietri S, Ponz de Leon M. Frequency and clinical features of multiple tumors of the large bowel in the general population and in patients with hereditary colorectal carcinoma. Cancer, 1996, 77(10):2013-21.Search in Google Scholar
Neugut AI, Lautenbach E, Abi-Rached B, Forde KA. Incidence of adenomas after curative resection for colorectal cancer. Am J Gastroenterol, 1996, 91(10):2096-8.Search in Google Scholar
Velayos FS, Lee SH, Qiu H, Dykes S, Yiu R, Terdiman JP, Garcia-Aguilar J. The mechanism of microsatellite instability is different in synchronous and metachronous colorectal cancer. J Gastrointest Surg, 2005, 9(3):329-35.Search in Google Scholar
Mulder SA, Kranse R, Damhuis RA, de Wilt JH, Ouwendijk RJ, Kuipers EJ, van Leerdam ME. Prevalence and prognosis of synchronous colorectal cancer: a Dutch population-based study. Cancer Epidemiol, 2011, 35(5):442-7.Search in Google Scholar
Hawk ET, Limburg PJ, Viner JL. Epidemiology and prevention of colorectal cancer. Surg Clin North Am, 2002, 82(5):905-41.Search in Google Scholar
Welch JP. Multiple colorectal tumors. An appraisal of natural history and therapeutic options. Am J Surg, 1981, 142(2):274-80.Search in Google Scholar
Ng SS, Li JC, Lee JF, Yiu RY, Leung KL. Laparoscopic total colectomy for colorectal cancers: a comparative study. Surg Endosc, 2006, 20(8):1193-6.Search in Google Scholar
Lacy AM, García-Valdecasas JC, Taurá P, Bordas JM, Grande L, Fuster J, Cugat E, Visa J. Is laparoscopic colectomy a safe procedure in synchronous colorectal carcinoma? Report of a case. Surg Laparosc Endosc, 1995, 5(1):75-6.Search in Google Scholar
Scheer A, Auer RA. Surveillance after curative resection of colorectal cancer. Clin Colon Rectal Surg, 2009, 22(4):242-50.Search in Google Scholar
Agnew JL, Abbadessa B, Leitman IM. Strategies to evaluate synchronous carcinomas of the colon and rectum in patients that present for emergent surgery. Int J Surg Oncol, 2013, 2013:309439.Search in Google Scholar
Kaibara N, Koga S, Jinnai D. Synchronous and metachronous malignancies of the colon and rectum in Japan with special reference to a coexisting early cancer. Cancer, 1984, 54(9):1870-4.Search in Google Scholar
Eguchi K, Yao T, Konomoto T, Hayashi K, Fujishima M, Tsuneyoshi M. Discordance of p53 mutations of synchronous colorectal carcinomas. Mod Pathol, 2000, 13(2):131-9.Search in Google Scholar
Sedivy R, Wolf B, Kalipciyan M, Steger GG, Karner-Hanusch J, Mader RM. Genetic analysis of multiple synchronous lesions of the colon adenoma-carcinoma sequence. Br J Cancer, 2000, 82(7):1276-82.Search in Google Scholar
Balschun K, Haag J, Wenke AK, von Schönfels W, Schwarz NT, Röcken C. KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications. J Mol Diagn, 2011, 13(4):436-45.Search in Google Scholar
Norrie MW, Hawkins NJ, Todd AV, Meagher AP, O’Connor TW, Ward RL. The role of hMLH1 methylation in the development of synchronous sporadic colorectal carcinomas. Dis Colon Rectum, 2002, 45(5):674-80.Search in Google Scholar
Aslanian HR, Burgart LJ, Harrington JJ, Mahoney DW, Zinsmeister AR, Thibodeau SN, Ahlquist DA. Altered DNA mismatch repair expression in synchronous and metachronous colorectal cancers. Clin Gastroenterol Hepatol, 2008, 6(12):1385-8.Search in Google Scholar
Box JC, Rodriguez-Bigas MA, Weber TK, Petrelli NJ. Clinical implications of multiple colorectal carcinomas in hereditary nonpolyposis colorectal carcinoma. Dis Colon Rectum, 1999, 42(6):717-21Search in Google Scholar
Andre T, Shiu KK, Kim TW, Jensen BV, Jensen LH, Punt C, et al. Pembrolizumab in microsatellite-Instability-High advanced colorectal cancer. N Engl J Med (2020) 383:2207–18.Search in Google Scholar
Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, et al. PD1 blockade in tumors with mismatch-repair deficiency. N Engl J Med (2015) 372:2509–20.Search in Google Scholar
Reitsam NG, Märkl B, Dintner S, Waidhauser J, Vlasenko D, Grosser B. Concurrent loss of MLH1, PMS2 and MSH6 immunoexpression in digestive system cancers indicating a widespread dysregulation in DNA repair processes. Front Oncol. 2022 Oct 26;12:1019798.Search in Google Scholar
McCarthy AJ, Capo-Chichi JM, Spence T, et al. Heterogenous loss of mismatch repair (mismatch repair) protein expression: a challenge for immunohistochemical interpretation and microsatellite instability (microsatellite instability) evaluation. J Pathol Clin Res 2019;5:115–129.Search in Google Scholar
van Riel E, Ausems MG, Hogervorst FB, et al. A novel pathogenic MLH1 missense mutation, c.112A > C, p. Asn38His, in six families with Lynch syndrome. Hered Cancer Clin Pract 2010;8:7.Search in Google Scholar
de Jong AE, van Puijenbroek M, Hendriks Y, et al. Microsatellite instability, immunohistochemistry, and additional PMS2 staining in suspected hereditary nonpolyposis colorectal cancer. Clin Cancer Res 2004;10:972–980.Search in Google Scholar
Hechtman JF, Rana S, Middha S, Stadler ZK, Latham A, Benayed R, Soslow R, Ladanyi M, Yaeger R, Zehir A, Shia J. Retained mismatch repair protein expression occurs in approximately 6% of microsatellite instability-high cancers and is associated with missense mutations in mismatch repair genes. Mod Pathol. 2020 May;33(5):871-879.Search in Google Scholar
Lynch PM. Hyperplastic polyposis: semantics, biology, and endoscopy. Gut 2010;59:1019–21.Search in Google Scholar
Win AK, Young JP, Lindor NM, et al. Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study. J Clin Oncol 2012;30:958–64.Search in Google Scholar
Rosty C, Clendenning M, Walsh MD on behalf of the Colon Cancer Family Registry Cohort, et al Germline mutations in PMS2 and MLH1 in individuals with solitary loss of PMS2 expression in colorectal carcinomas from the Colon Cancer Family Registry Cohort BMJ Open 2016;6:e010293.Search in Google Scholar
Lindor NM, Burgart LJ, Leontovich O, et al. Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. J Clin Oncol 2002;20:1043–8Search in Google Scholar
de Jong AE, van Puijenbroek M, Hendriks Y, et al. Microsatellite instability, immunohistochemistry, and additional PMS2 staining in suspected hereditary nonpolyposis colorectal cancer. Clin Cancer Res 2004;10:972–80.Search in Google Scholar
He W, Zheng C, Wang Y, Dan J, Zhu M, Wei M, et al. Prognosis of synchronous colorectal carcinoma compared to solitary colorectal carcinoma: a matched pair analysis. Eur J Gastroenterol Hepatol. 2019 Dec;31(12):1489-95.Search in Google Scholar
Shia J, Zhang L, Shike M, Guo M, Stadler Z, Xiong X, et al. Secondary mutation in a coding mononucleotide tract in MSH6 causes loss of immunoexpression of MSH6 in colorectal carcinomas with MLH1/PMS2 deficiency. Mod Pathol. 2013 Jan;26(1):131-8Search in Google Scholar