<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Cypermethrin (CP) is a toxic insecticide to fishes. Chrysin (CR) is a flavonoid, which can be obtained from plants. The aim of this study was to determine the effects of CR in fishes that had acute CP toxicity. In the study, a total of 60 fishes were used and added to feed and water with CR and CP for 10 days. Blood and tissue samples were collected. The serum enzymes aspartate transaminase (AST) and alanine aminotransferase (ALT), interleukin-1 beta (IL-1β), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) levels/activities were determined for liver and kidneys. In this study, when the CP group was compared to the control group, an increase was observed in the levels/activities of AST, ALT, IL-1ß, TNF-α, and IL-6, otherwise, there was a decrease in the IL-10 level in the CP group. Additionally, an increase of MDA levels and a decrease of SOD, GSH-Px, and CAT levels/activities were observed in the CP group. When the CP group was compared to the CR groups, there was a decrease in IL-1β, IL-6, TNF-α, ALT, AST, and MDA levels/activities and there was an increase, depending on the dosage in GSH-Px, SOD, and CAT levels/activities of the CR groups. In conclusion, CR can prevent tissue damage, affecting oxidation via anti-inflammatory and anti-oxidative effects of acute toxicity of fishes exposed to CP.</p></abstract>

Cypermethrin (CP) is a toxic insecticide to fishes. Chrysin (CR) is a flavonoid, which can be obtained from plants. The aim of this study was to determine the effects of CR in fishes that had acute CP toxicity. In the study, a total of 60 fishes were used and added to feed and water with CR and CP for 10 days. Blood and tissue samples were collected. The serum enzymes aspartate transaminase (AST) and alanine aminotransferase (ALT), interleukin-1 beta (IL-1β), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) levels/activities were determined for liver and kidneys. In this study, when the CP group was compared to the control group, an increase was observed in the levels/activities of AST, ALT, IL-1ß, TNF-α, and IL-6, otherwise, there was a decrease in the IL-10 level in the CP group. Additionally, an increase of MDA levels and a decrease of SOD, GSH-Px, and CAT levels/activities were observed in the CP group. When the CP group was compared to the CR groups, there was a decrease in IL-1β, IL-6, TNF-α, ALT, AST, and MDA levels/activities and there was an increase, depending on the dosage in GSH-Px, SOD, and CAT levels/activities of the CR groups. In conclusion, CR can prevent tissue damage, affecting oxidation via anti-inflammatory and anti-oxidative effects of acute toxicity of fishes exposed to CP.

The effects of chrysin on cypermethrin-induced acute intoxication in rainbow trout (<italic>Oncorhynchus mykiss</italic>)

Institute of Health Sciences, Veterinary Pharmacology and Toxicology

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine

Fisheries & Aquatic Life

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The effects of chrysin on cypermethrin-induced acute intoxication in rainbow trout ()

Cypermethrin (CP) is a toxic insecticide to fishes. Chrysin (CR) is a flavonoid, which can be obtained from plants. The aim of this study was to determine the...

The effects of chrysin on cypermethrin-induced acute intoxication in rainbow trout (Oncorhynchus mykiss)

Published Online: Aug 21, 2019

Page range: 102 - 111

Received: Nov 14, 2018

Accepted: Jun 06, 2019

DOI: https://doi.org/10.2478/aopf-2019-0011

Keywords
Antioxidant, fish, chrysin, cypermethrin, cytokine, toxication

© 2019 Ozge Cerit et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The effects of chrysin on cypermethrin-induced acute intoxication in rainbow trout (Oncorhynchus mykiss)

Published Online: Aug 21, 2019

Page range: 102 - 111

Received: Nov 14, 2018

Accepted: Jun 06, 2019

DOI: https://doi.org/10.2478/aopf-2019-0011

KeywordsAntioxidant, fish, chrysin, cypermethrin, cytokine, toxication

© 2019 Ozge Cerit et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Antioxidant, fish, chrysin, cypermethrin, cytokine, toxication