<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Development of the skeletal muscle goes through several complex processes regulated by numerous genetic factors. Although much efforts have been made to understand the mechanisms involved in increased muscle yield, little work is done about the miRNAs and candidate genes that are involved in the skeletal muscle development in poultry. Comprehensive research of candidate genes and single nucleotide related to poultry muscle growth is yet to be experimentally unraveled. However, over a few periods, studies in miRNA have disclosed that they actively participate in muscle formation, differentiation, and determination in poultry. Specifically, miR-1, miR-133, and miR-206 influence tissue development, and they are highly expressed in the skeletal muscles. Candidate genes such as <italic>CEBPB</italic>, <italic>MUSTN1</italic>, <italic>MSTN</italic>, <italic>IGF1</italic>, <italic>FOXO3</italic>, <italic>mTOR</italic>, and <italic>NFKB1</italic>, have also been identified to express in the poultry skeletal muscles development. However, further researches, analysis, and comprehensive studies should be made on the various miRNAs and gene regulatory factors that influence the skeletal muscle development in poultry. The objective of this review is to summarize recent knowledge in miRNAs and their mode of action as well as transcription and candidate genes identified to regulate poultry skeletal muscle development.</p></abstract>

Development of the skeletal muscle goes through several complex processes regulated by numerous genetic factors. Although much efforts have been made to understand the mechanisms involved in increased muscle yield, little work is done about the miRNAs and candidate genes that are involved in the skeletal muscle development in poultry. Comprehensive research of candidate genes and single nucleotide related to poultry muscle growth is yet to be experimentally unraveled. However, over a few periods, studies in miRNA have disclosed that they actively participate in muscle formation, differentiation, and determination in poultry. Specifically, miR-1, miR-133, and miR-206 influence tissue development, and they are highly expressed in the skeletal muscles. Candidate genes such as CEBPB, MUSTN1, MSTN, IGF1, FOXO3, mTOR, and NFKB1, have also been identified to express in the poultry skeletal muscles development. However, further researches, analysis, and comprehensive studies should be made on the various miRNAs and gene regulatory factors that influence the skeletal muscle development in poultry. The objective of this review is to summarize recent knowledge in miRNAs and their mode of action as well as transcription and candidate genes identified to regulate poultry skeletal muscle development.

Mechanism and Functions of Identified miRNAs in Poultry Skeletal Muscle Development – A Review

Annals of Animal Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Development of the skeletal muscle goes through several complex processes regulated by numerous genetic factors. Although much efforts have been made to...

Mechanism and Functions of Identified miRNAs in Poultry Skeletal Muscle Development – A Review

Published Online: Oct 30, 2019

Page range: 887 - 904

Received: Apr 24, 2019

Accepted: Jul 25, 2019

DOI: https://doi.org/10.2478/aoas-2019-0049

Keywords
poultry, skeletal muscle development, miRNAs, genes, proliferation, differentiation

© 2019 Asiamah Amponsah Collins et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mechanism and Functions of Identified miRNAs in Poultry Skeletal Muscle Development – A Review

Published Online: Oct 30, 2019

Page range: 887 - 904

Received: Apr 24, 2019

Accepted: Jul 25, 2019

DOI: https://doi.org/10.2478/aoas-2019-0049

Keywordspoultry, skeletal muscle development, miRNAs, genes, proliferation, differentiation

© 2019 Asiamah Amponsah Collins et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
poultry, skeletal muscle development, miRNAs, genes, proliferation, differentiation