<abstract xmlns="http://www.w3.org/1999/xhtml">The aim of the study was to assess the biocompatibility of gold nanoparticles (Au-NPs) for chickens by investigating their effect on their growth, hematological parameters, markers of oxidative stress, and indicators of liver and kidney function. The experiment was carried out on 54 chickens assigned to 3 experimental groups of 18 birds each. The control group did not receive gold nanoparticles. The birds in group Au-NPs2.0 received gold nanoparticles in a tube into a crop at a rate of 2.0 mg/kg body weight/day, while the birds in AuNPs5.0 group at a rate of 5.0 mg/kg body weight/day. The blood for analysis was collected after 7, 14, 21 and 28 days of Au-NPs application. The obtained results indicate that short-term (7–14 day) exposure to lower dose (2.0 mg/kg b.w./day) of AuNPs had no toxic impact on chickens, but the extension of the duration time caused toxicological effects evidenced by growth inhibition as well as induction of oxidative stress and liver injury. The higher dose of AuNPs (5.0 mg/kg b.w./day) exerted toxic effects already after 7–14 days of supplementation.</abstract>

The aim of the study was to assess the biocompatibility of gold nanoparticles (Au-NPs) for chickens by investigating their effect on their growth, hematological parameters, markers of oxidative stress, and indicators of liver and kidney function. The experiment was carried out on 54 chickens assigned to 3 experimental groups of 18 birds each. The control group did not receive gold nanoparticles. The birds in group Au-NPs2.0 received gold nanoparticles in a tube into a crop at a rate of 2.0 mg/kg body weight/day, while the birds in AuNPs5.0 group at a rate of 5.0 mg/kg body weight/day. The blood for analysis was collected after 7, 14, 21 and 28 days of Au-NPs application. The obtained results indicate that short-term (7–14 day) exposure to lower dose (2.0 mg/kg b.w./day) of AuNPs had no toxic impact on chickens, but the extension of the duration time caused toxicological effects evidenced by growth inhibition as well as induction of oxidative stress and liver injury. The higher dose of AuNPs (5.0 mg/kg b.w./day) exerted toxic effects already after 7–14 days of supplementation.

Redox Status, Hematological Parameters as Well Liver and Kidney Function Indicators in Blood of Chickens Receiving Gold Nanoparticles

Department of Biochemistry and Toxicology, Faculty of Biology, Animal Sciences and Bioeconomy

Annals of Animal Science

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The aim of the study was to assess the biocompatibility of gold nanoparticles (Au-NPs) for chickens by investigating their effect on their growth,...

Redox Status, Hematological Parameters as Well Liver and Kidney Function Indicators in Blood of Chickens Receiving Gold Nanoparticles

Published Online: May 02, 2019

Page range: 453 - 468

Received: Oct 11, 2018

Accepted: Dec 12, 2018

DOI: https://doi.org/10.2478/aoas-2018-0060

Keywords
nano-gold, biocompatibility, toxicity, oxidative stress, blood indices, chicken

© 2019 Iwona Sembratowicz et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Redox Status, Hematological Parameters as Well Liver and Kidney Function Indicators in Blood of Chickens Receiving Gold Nanoparticles

Published Online: May 02, 2019

Page range: 453 - 468

Received: Oct 11, 2018

Accepted: Dec 12, 2018

DOI: https://doi.org/10.2478/aoas-2018-0060

Keywordsnano-gold, biocompatibility, toxicity, oxidative stress, blood indices, chicken

© 2019 Iwona Sembratowicz et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
nano-gold, biocompatibility, toxicity, oxidative stress, blood indices, chicken