<abstract xmlns="http://www.w3.org/1999/xhtml"><p>We performed a literature review of studies comparing the effectiveness of progestins in preventing premature ovulation during ovarian stimulation for assisted reproductive technology (ART). Five randomized trials and cohort studies involving a total of 2404 women, which compared; i) two different progestins or ii) two different doses of the same progestin were included. The primary outcome was live birth rate (LBR) per woman. Secondary outcomes were live birth or ongoing pregnancy (LB/OP) per woman and per embryo transfer (ET), ongoing pregnancy, clinical pregnancy, positive pregnancy test, numbers of oocytes and metaphase-two oocytes, duration of stimulation and gonadotropin consumption. The primary outcome was not reported in most studies however there were no differences between progestins for secondary outcomes. All progestins seem to effectively prevent premature ovulation in ART cycles. Low-quality evidence suggests that progestins can effectively prevent premature ovulation in ART cycles.</p></abstract>

We performed a literature review of studies comparing the effectiveness of progestins in preventing premature ovulation during ovarian stimulation for assisted reproductive technology (ART). Five randomized trials and cohort studies involving a total of 2404 women, which compared; i) two different progestins or ii) two different doses of the same progestin were included. The primary outcome was live birth rate (LBR) per woman. Secondary outcomes were live birth or ongoing pregnancy (LB/OP) per woman and per embryo transfer (ET), ongoing pregnancy, clinical pregnancy, positive pregnancy test, numbers of oocytes and metaphase-two oocytes, duration of stimulation and gonadotropin consumption. The primary outcome was not reported in most studies however there were no differences between progestins for secondary outcomes. All progestins seem to effectively prevent premature ovulation in ART cycles. Low-quality evidence suggests that progestins can effectively prevent premature ovulation in ART cycles.

The Review of Compared Progestins Type and Dose Utility against the Pituitary Suppression during Ovarian Stimulation for Assisted Reproductive Technology

“George Emil Palade” University of Medicine, Pharmacy, Science and Technology

Acta Medica Transilvanica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

We performed a literature review of studies comparing the effectiveness of progestins in preventing premature ovulation during ovarian stimulation for assisted...

The Review of Compared Progestins Type and Dose Utility against the Pituitary Suppression during Ovarian Stimulation for Assisted Reproductive Technology

Published Online: Aug 03, 2020

Page range: 45 - 47

Received: Mar 20, 2020

Accepted: May 28, 2020

DOI: https://doi.org/10.2478/amtsb-2020-0029

Keywords
progestins, ovarian stimulation, IVF, assisted reproduction

© 2020 Alexandru Polexa et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Review of Compared Progestins Type and Dose Utility against the Pituitary Suppression during Ovarian Stimulation for Assisted Reproductive Technology

Published Online: Aug 03, 2020

Page range: 45 - 47

Received: Mar 20, 2020

Accepted: May 28, 2020

DOI: https://doi.org/10.2478/amtsb-2020-0029

Keywordsprogestins, ovarian stimulation, IVF, assisted reproduction

© 2020 Alexandru Polexa et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
progestins, ovarian stimulation, IVF, assisted reproduction