Vitamin K2 in Osteoporosis Treatment

1. Consensus development conference: Diagnosis, prophylaxis, and treatment of osteoporosis, The American Journal of Medicine. 1993;94(6):646-650.10.1016/0002-9343(93)90218-ESearch in Google Scholar

2. Kanis JA, Cooper C, Rizzoli R, Reginster JY. Executive summary of the European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Calcif Tissue Int. 2019;104(3):235–8.10.1007/s00223-018-00512-xSearch in Google Scholar

3. Butler L. March 19, 1960 NATURE. 1960;17(4716):4716.Search in Google Scholar

4. Ebina K, Noguchi T, Hirao M, Kaneshiro S, Tsukamoto Y, Yoshikawa H. Comparison of the effects of 12 months of monthly minodronate monotherapy and monthly minodronate combination therapy with vitamin K2 or eldecalcitol in patients with primary osteoporosis. J Bone Miner Metab. 2016;34(3):243–50.10.1007/s00774-015-0710-2Search in Google Scholar

5. Douglas AS, Robins SP, Hutchison JD, Porter RW, Stewart A, Reid DM. Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation. Bone. 1995;17(1):15–20.10.1016/8756-3282(95)00133-XSearch in Google Scholar

6. Iwamoto J, Takeda T, Ichimura S. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis. J Orthop Sci. 2000;5(6):546–51.10.1007/s00776007000311180916Search in Google Scholar

7. Shiraki M, Shiraki Y, Aoki C, Miura M. Vitamin K2 (Menatetrenone) Effectively Prevents Fractures and Sustains Lumbar Bone Mineral Density in Osteoporosis. J Bone Miner Res. 2010;15(3):515–21.10.1359/jbmr.2000.15.3.51510750566Search in Google Scholar

8. Iwamoto J, Takeda T, Ichimura S. Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis: A comparison with the effect of etidronate. J Orthop Sci. 2001;6(6):487–92.10.1007/s00776010000211793169Search in Google Scholar

9. Ishida Y, Kawai S. Comparative efficacy of hormone replacement therapy, etidronate, calcitonin, alfacalcidol, and vitamin K in postmenopausal women with osteoporosis: The Yamaguchi Osteoporosis Prevention Study. Am J Med. 2004;117(8):549–55.10.1016/j.amjmed.2004.05.01915465502Search in Google Scholar

10. Tanaka S, Miyazaki T, Uemura Y, Miyakawa N, Gorai I, Nakamura T, et al. Comparison of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis: Japanese Osteoporosis Intervention Trial-03. J Bone Miner Metab. 2017;35(4):385–95.10.1007/s00774-016-0768-527484436Search in Google Scholar

11. Kasukawa Y, Miyakoshi N, Ebina T, Aizawa T, Hongo M, Nozaka K, et al. Effects of risedronate alone or combined with vitamin K2on serum undercarboxylated osteocalcin and osteocalcin levels in postmenopausal osteoporosis. J Bone Miner Metab. 2014;32(3):290–7.10.1007/s00774-013-0490-523846118Search in Google Scholar

12. Miki T, Nakatsuka K, Naka H, Kitatani K, Saito S, Masaki H, et al. Vitamin K2 (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis. J Bone Miner Metab. 2003;21(3):161–5.10.1007/s00774030002512720050Search in Google Scholar

13. Shiraki M, Itabashi A. Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase of bone turnover in postmenopausal osteoporosis: A randomized prospective study. J Bone Miner Metab. 2009;27(3):333–40.10.1007/s00774-008-0034-619172219Search in Google Scholar

14. Inoue T, Fujita T, Kishimoto H, Makino T, Nakamura T, Nakamura T, et al. Randomized controlled study on the prevention of osteoporotic fractures (OF study): A phase IV clinical study of 15-mg menatetrenone capsules. J Bone Miner Metab. 2009;27(1):66–75.10.1007/s00774-008-0008-819082528Search in Google Scholar