Open Access

Development and Validation of an UHPLC Method for Ostarine Determination in Dietary Supplements


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1. Thevis M, Schänzer W. Detection of SARMs in doping control analysis. Mol Cell Endocrinol. 2018; 464:34-45.10.1016/j.mce.2017.01.040Search in Google Scholar

2. Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW. Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. Sex Med Rev. 2019; 7(1):84-94.10.1016/j.sxmr.2018.09.006Search in Google Scholar

3. Miklos A, Tero-Vescan A, Vari CE, Ősz BE, Filip C, Rusz CM, Muntean DL. Selective androgen receptor modulators (SARMs) in the context of doping. Farmacia. 2018; 66(5):758-762.10.31925/farmacia.2018.5.3Search in Google Scholar

4. https://www.wada-ama.org/sites/default/files/prohibited_list_2018_en.pdfSearch in Google Scholar

5. Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M. Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry. Rapid Commun Mass Spectrom. 2016; 30(7):833-842.10.1002/rcm.7512Search in Google Scholar

6. Dobs AS, Boccia RV, Croot CC, Gabrail NY, Dalton JT, Hancock ML, Johnston MA, Steiner MS. Efects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol. 2013; 14:335–345.10.1016/S1470-2045(13)70055-XSearch in Google Scholar

7. European Pharmacopoeia 7th Edition, 2.9.5:265-266.Search in Google Scholar

8. https://www.ema.europa.eu/en/documents/scientific-guideline/ich-q-2-r1-validation-analytical-procedures-text-methodology-step-5_en.pdfSearch in Google Scholar

9. Cesbron N, Sydor A, Penot M, Prevost S, Le Bizec B, Dervilly-Pinel G. Analytical strategies to detect enobosarm administration in bovines. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017; 34(4):632-640.10.1080/19440049.2016.125812227827563Search in Google Scholar

10. https://cces.ca/canadian-sport-sanction-registrySearch in Google Scholar

11. Coss CC, Jones A, Dalton JT. Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024(Enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin. Invest New Drugs. 2016; 34(4):458-67.10.1007/s10637-016-0353-827105861Search in Google Scholar

12. Thevis M, Lagojda A, Kuehne D, Thomas A, Dib J, Hansson A, Hedeland M, Bondesson U, Wigger T, Karst U, Schänzer W. Characterization of a non-approved selective androgen receptor modulator drug candidate sold via the Internet and identification of in vitro generated phase-I metabolites for human sports drug testing. Rapid Commun Mass Spectrom. 2015; 29(11):991-999.10.1002/rcm.718926044265Search in Google Scholar

13. Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017; 318(20):2004-2010.10.1001/jama.2017.17069582069629183075Search in Google Scholar

eISSN:
2247-6113
Language:
English
Publication timeframe:
6 times per year
Journal Subjects:
Medicine, Clinical Medicine, other