<abstract xmlns="http://www.w3.org/1999/xhtml">Cerebral venous thrombosis (CVT) represents 1% of the total stroke pathology but is a real challenge both regarding the diagnosis and the treatment. Objective: Evaluate different etiological, demographical, clinical, imaging and therapeutic aspects of CVT. Material: Prospective study during 4 years. From the total 3658 patients hospitalized with acute stroke, 45 (1.23%) had CVT. For each patient, were recorded: demographic data, symptom of onset, type of onset, daily habits, medical history, neurological examination, brain imaging (CT and MRI with venography). Statistical analysis: data are presented as mean and SD and Student t test was applied. Results: Mean age was 44.07± 23,12 years; female: male ratio 2.21:1. The most frequent type of onset was acute (77.78%). Headache was found in 80% of cases as initial symptom, followed by neurological focal deficits. As risk factors, thrombophilia was found most often (59.5%), followed by local infections. No risk factors were found in 17.8% of cases. The brain imaging was positive in 29 patients. In 16 cases, the imaging workout was negative and the diagnosis consisted of clinical criteria, risk factors, response to heparin treatment. Conclusions: CVT is a rare pathology that affects mainly young women and that needs a complex diagnostic evaluation. The patient prototype diagnosed with CVT in our region: female of 44 years old, with an intense acute headache, with MRI showing direct signs of transverse sinus thrombosis, with a thrombophilic state and good response to anticoagulants. Brain MRI is the imaging investigation required but clinical aspects play a decisive role.</abstract>

Cerebral venous thrombosis (CVT) represents 1% of the total stroke pathology but is a real challenge both regarding the diagnosis and the treatment. Objective: Evaluate different etiological, demographical, clinical, imaging and therapeutic aspects of CVT. Material: Prospective study during 4 years. From the total 3658 patients hospitalized with acute stroke, 45 (1.23%) had CVT. For each patient, were recorded: demographic data, symptom of onset, type of onset, daily habits, medical history, neurological examination, brain imaging (CT and MRI with venography). Statistical analysis: data are presented as mean and SD and Student t test was applied. Results: Mean age was 44.07± 23,12 years; female: male ratio 2.21:1. The most frequent type of onset was acute (77.78%). Headache was found in 80% of cases as initial symptom, followed by neurological focal deficits. As risk factors, thrombophilia was found most often (59.5%), followed by local infections. No risk factors were found in 17.8% of cases. The brain imaging was positive in 29 patients. In 16 cases, the imaging workout was negative and the diagnosis consisted of clinical criteria, risk factors, response to heparin treatment. Conclusions: CVT is a rare pathology that affects mainly young women and that needs a complex diagnostic evaluation. The patient prototype diagnosed with CVT in our region: female of 44 years old, with an intense acute headache, with MRI showing direct signs of transverse sinus thrombosis, with a thrombophilic state and good response to anticoagulants. Brain MRI is the imaging investigation required but clinical aspects play a decisive role.

Risk factors and diagnosis of cerebral venous thrombosis: Data from a cohort of 45 Romanian patients

First Neurological Clinic, Regional MS Centre, University Emergency County Hospital, Târgu Mureş, University of Medicine and Pharmacy Târgu Mureș, România

Neurosurgery Department, University Emergency County Hospital Târgu Mureş, România

Acta Marisiensis - Seria Medica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Cerebral venous thrombosis (CVT) represents 1% of the total stroke pathology but is a real challenge both regarding the diagnosis and the treatment. Objective:...

Risk factors and diagnosis of cerebral venous thrombosis: Data from a cohort of 45 Romanian patients

Published Online: Dec 04, 2014

Page range: 207 - 214

Received: Oct 16, 2014

Accepted: Oct 25, 2014

DOI: https://doi.org/10.2478/amma-2014-0044

Keywords
cerebral venous thrombosis, venous infarction, MR venography, CT venography

© by Rodica Bălaşa

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Risk factors and diagnosis of cerebral venous thrombosis: Data from a cohort of 45 Romanian patients

Published Online: Dec 04, 2014

Page range: 207 - 214

Received: Oct 16, 2014

Accepted: Oct 25, 2014

DOI: https://doi.org/10.2478/amma-2014-0044

Keywordscerebral venous thrombosis, venous infarction, MR venography, CT venography

© by Rodica Bălaşa

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
cerebral venous thrombosis, venous infarction, MR venography, CT venography