<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Physiological functions of cardiovascular system (CVS) are exhibiting circadian patterns regulated by complex system of endogenous factors. Preserving this rhythmicity is important for its normal function, whereas disturbing the synchronization with natural day–night cycle can increase the risk of cardiovascular damage. Cardiovascular pathophysiology also follows cyclic variation; time susceptibility and period with maximum risk associated with elevated blood pressure (BP) can be predicted. Given this rhythmic nature, significant changes in efficacy between morning and evening administration of the drug may occur; appropriate timing of pharmacological intervention in therapy of hypertension may affect the efficacy of the treatment.</p>
</abstract>

Physiological functions of cardiovascular system (CVS) are exhibiting circadian patterns regulated by complex system of endogenous factors. Preserving this rhythmicity is important for its normal function, whereas disturbing the synchronization with natural day–night cycle can increase the risk of cardiovascular damage. Cardiovascular pathophysiology also follows cyclic variation; time susceptibility and period with maximum risk associated with elevated blood pressure (BP) can be predicted. Given this rhythmic nature, significant changes in efficacy between morning and evening administration of the drug may occur; appropriate timing of pharmacological intervention in therapy of hypertension may affect the efficacy of the treatment.

Chronopharmacology of high blood pressure—a critical review of clinical evidence

European Pharmaceutical Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Physiological functions of cardiovascular system (CVS) are exhibiting circadian patterns regulated by complex system of endogenous factors. Preserving this...

Chronopharmacology of high blood pressure—a critical review of clinical evidence

Published Online: Jan 28, 2020

Page range: 32 - 36

Received: Jul 03, 2019

Accepted: Sep 26, 2019

DOI: https://doi.org/10.2478/afpuc-2019-0017

Keywords
chronopharmacology, blood pressure, circadian rhythm, non-dipping

© 2019 P. Potucek et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Chronopharmacology of high blood pressure—a critical review of clinical evidence

Published Online: Jan 28, 2020

Page range: 32 - 36

Received: Jul 03, 2019

Accepted: Sep 26, 2019

DOI: https://doi.org/10.2478/afpuc-2019-0017

Keywordschronopharmacology, blood pressure, circadian rhythm, non-dipping

© 2019 P. Potucek et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
chronopharmacology, blood pressure, circadian rhythm, non-dipping