Immuno-histomorphometric and -fluorescent characteristics of GH cells after treatment with genistein or daidzein in an animal model of andropause

1. Melmed S: Idiopathic adult growth hormone defi ciency. J Clin Endocrinol Metab 2013, 98:2187-2197.10.1210/jc.2012-4012366726723539718Search in Google Scholar

2. Morales A: Andropause (or s ymptomatic late-onset hypogonadism): facts, fi ction and controversies. Aging Male 2004, 7:297-303.10.1080/1368553040001666415799125Search in Google Scholar

3. Thompson CA, Shanafelt TD, Loprinzi CL: Andropause: symptom management for prostate cancer patients treated with hormonal ablation. Oncologist 2003, 8:474-487.10.1634/theoncologist.8-5-47414530501Search in Google Scholar

4. Epelbaum J: Neuroendocrinol ogy and aging. J Neuroendocrinol 2008, 20:808-811.10.1111/j.1365-2826.2008.01720.x18601703Search in Google Scholar

5. Milosevic V, Trifunovic S, Sosic-Jurjevic B, Bujsic N, Sekulic M: Estradiol and calcium affect the growth hormone producing cells in female middle-aged rats. Acta Vet-Beograd 2005, 55:111-120.10.2298/AVB0503111MSearch in Google Scholar

6. Russell-Aulet M, Dimaraki E V, Jaffe CA, DeMott-Friberg R, Barkan AL: Aging-related growth hormone (GH) decrease is a selective hypothalamic GH-releasing hormone pulse amplitude mediated phenomenon. J Gerontol A Biol Sci Med Sci 2001, 56:M124-129.10.1093/gerona/56.2.M12411213276Search in Google Scholar

7. Kuwahara S, Sari DK, Tsukam oto Y, Tanaka S, Sasaki F: Age-related changes in growth hormone (GH) cells in the pituitary gland of male mice are mediated by GH-releasing hormone but not by somatostatin in the hypothalamus. Brain Res 2004, 998:164-173.10.1016/j.brainres.2003.10.06014751587Search in Google Scholar

8. Takahashi S: Heterogenity a nd development of somatotrophs and mammotrophs in the rat. Zoolog Sci 1992, 9:901-924.Search in Google Scholar

9. Ceda GP, Dall’Aglio E, Morg anti S, Denti L, Maggio M, Lauretani F, Andrea A, Ceresini G, Cattabiani C, Valenti G: Update on new therapeutic options for the somatopause. Acta Biomed 2010, 81 Suppl 1:67-72.Search in Google Scholar

10. Misztal T, Wankowska M, Go rski K, Romanowicz K: Central estrogen-like effect of genistein on growth hormone secretion in the ewe. Acta Neurobiol Exp (Wars) 2007, 67:411-419.Search in Google Scholar

11. Scanlan N, Skinner DC: Est radiol modulation of growth hormone secretion in the ewe: no growth hormone-releasing hormone neurons and few somatotropes express estradiol receptor alpha. Biol Reprod 2002, 66:1267-1273.10.1095/biolreprod66.5.126711967186Search in Google Scholar

12. Ogiwara T, Chik CL, Ho AK: Tyrosine kinase inhibitors enhance GHRH-stimulated cAMP accumulation and GH release in rat anterior pituitary cells. J Endocrinol 1997, 152:193-199. 10.1677/joe.0.15201939071976Search in Google Scholar

13. Picherit C, Coxam V, Benne tau-Pelissero C, Kati-Coulibaly S, Davicco MJ, Lebecque P, Barlet JP: Daidzein is more effi cient than genistein in preventing ovariectomy-induced bone loss in rats. J Nutr 2000, 130:1675-1681.10.1093/jn/130.7.167510867035Search in Google Scholar

14. Ajdzanovic VZ, Sosic-Jurje vic BT, Filipovic BR, Trifunovic SL, Milosevic V: Daidzein effects on ACTH cells: immunohistomorphometric and hormonal study in an animal model of the andropause. Histol Histopathol 2011, 26:1257-1264.Search in Google Scholar

15. Ajdzanovic VZ, Sosic-Jurje vic BT, Filipovic BR, Trifunovic SL, Brkic DD, Sekulic MI, Milosevic V: Genistein affects the morphology of pituitary ACTH cells and decreases circulating levels of ACTH and corticosterone in middle-aged male rats. Biol Res 2009, 42:13-23.10.4067/S0716-97602009000100002Search in Google Scholar

16. Pantelic J, Filipovic B, S osic-Jurjevic B, Ajdzanovic V, Trifunovic S, Medigovic I, Milosevic V: Vitex agnus-castus essential oil affects thyroid C cells and bone metabolism in middleaged male rats. Acta Vet-Beograd 2013, 63:23-35.10.2298/AVB1301023PSearch in Google Scholar

17. Sternberger LA, Hardy PH, Jr., Cuculis JJ, Meyer HG: The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identifi cation of spirochetes. J Histochem Cytochem 1970, 18:315-333.10.1177/18.5.3154192899Search in Google Scholar

18. Milosevic V, Brkic B, Velk ovski S, Starcevic V: Somatostatin induced changes of the ACTH and STH cells in the hypophysis of the male rats. Jugoslav Med Biohem 1994, 13:102-106.Search in Google Scholar

19. Weibel ER: 1. Practical Me thods for Biological Morphometry. In: Stereological Methods. London, UK: Academic Press; 1979, 1-415.Search in Google Scholar

20. Poole MC, Kornegay 3rd WD: Cellular distribution within the rat adenohypophysis: a morphometric study. Anat Rec 1982, 204:45-53.10.1002/ar.10920401077149283Search in Google Scholar

21. Filipovic B, Sosic-Jurjevi c B, Ajdzanovic V, Brkic D, Manojlovic-Stojanoski M, Milosevic V, Sekulic M: Daidzein administration positively affects thyroid C cells and bone structure in orchidectomized middle-aged rats. Osteoporos Int 2010, 21:1609-1616.10.1007/s00198-009-1092-x19859640Search in Google Scholar

22. Penza M, Montani C, Romani A, Vignolini P, Pampaloni B, Tanini A, Brandi ML, Alonso- Magdalena P, Nadal A, Ottobrini L et al: Genistein affects adipose tissue deposition in a dose-dependent and gender-specifi c manner. Endocrinology 2006, 147:5740-5751.10.1210/en.2006-036516959845Search in Google Scholar

23. Faqi AS, Johnson WD, Morri ssey RL, McCormick DL: Reproductive toxicity assessment of chronic dietary exposure to soy isofl avones in male rats. Reprod Toxicol 2004, 18:605-611.10.1016/j.reprotox.2004.02.01315135855Search in Google Scholar

24. Yokoshiki H, Sumii K, Sper elakis N: Inhibition of L-type calcium current in rat ventricular cells by the tyrosine kinase inhibitor, genistein and its inactive analog, daidzein. J Mol Cell Cardiol 1996, 28:807-814.10.1006/jmcc.1996.00758732508Search in Google Scholar

25. Zhong W, Atkin SL: Modulat ion of somatostatin receptors expression by genistein in human umbilical vein endothelial cells. Endocrine Abstracts 2005, 9:P38.Search in Google Scholar

26. Barbieri F, Bajetto A, Pat tarozzi A, Gatti M, Wurth R, Thellung S, Corsaro A, Villa V, Nizzari M, Florio T: Peptide receptor targeting in cancer: the somatostatin paradigm. Int J Pept 2013, 2013:926295. 10.1155/2013/926295358210423476673Search in Google Scholar