<abstract xmlns="http://www.w3.org/1999/xhtml"><p> In the aged dog and cat, especially dog, a cognitive decline develops naturally in many different domains, but at the same time it also exhibits human-like individual variability in the aging process. In the aging dog and cat brain lesions develop spontaneously. Dogs share some morphological characteristics with those of Alzheimer’s disease in man. The canine brain with its plaques and tangles which show oxidative changes, forms a spontaneous model for understanding the early changes and their interrelationships in Alzheimer’s disease. Additionally, the aged dog represents a useful model for the development of preventive or therapeutic interventions to improve aged brain function. These interventions can then be translated into human clinical trials.</p></abstract>

In the aged dog and cat, especially dog, a cognitive decline develops naturally in many different domains, but at the same time it also exhibits human-like individual variability in the aging process. In the aging dog and cat brain lesions develop spontaneously. Dogs share some morphological characteristics with those of Alzheimer’s disease in man. The canine brain with its plaques and tangles which show oxidative changes, forms a spontaneous model for understanding the early changes and their interrelationships in Alzheimer’s disease. Additionally, the aged dog represents a useful model for the development of preventive or therapeutic interventions to improve aged brain function. These interventions can then be translated into human clinical trials.

Principles of age-related changes in the canine and feline brain	

Department of Pathology, School of Health Sciences, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 54 124 Thessaloniki, Greece

Acta Veterinaria

{"article-title":"Principles of age-related changes in the canine and feline brain"}

In the aged dog and cat, especially dog, a cognitive decline develops naturally in many different domains, but at the same time it also exhibits human-like...

Principles of age-related changes in the canine and feline brain

Published Online: Mar 25, 2014

Page range: 1 - 9

DOI: https://doi.org/10.2478/acve-2014-0001

Keywords
aged dogs, aged cats, amyloid, Alzheimer disease, oxidative damage

This content is open access.

Principles of age-related changes in the canine and feline brain

Published Online: Mar 25, 2014

Page range: 1 - 9

DOI: https://doi.org/10.2478/acve-2014-0001

Keywordsaged dogs, aged cats, amyloid, Alzheimer disease, oxidative damage

This content is open access.

Keywords
aged dogs, aged cats, amyloid, Alzheimer disease, oxidative damage