<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Berberine (<bold>1</bold>), as a compound with interesting biological activities, can be modified at various positions to obtain more potent substances. Modifications at position 9 are based on demethylation with simultaneous dechloration resulting in berberrubine. The most frequent process is thermal dechloromethylation and this work describes this method with detailed tricks to obtain almost pure product in high yield.</p></abstract>

Berberine (1), as a compound with interesting biological activities, can be modified at various positions to obtain more potent substances. Modifications at position 9 are based on demethylation with simultaneous dechloration resulting in berberrubine. The most frequent process is thermal dechloromethylation and this work describes this method with detailed tricks to obtain almost pure product in high yield.

Dechloromethylation of the berberine to berberrubine — tricks to obtain pure product

Acta Chimica Slovaca

This work is licensed under the Creative Commons Attribution 4.0 Public License.

Berberine (1), as a compound with interesting biological activities, can be modified at various positions to obtain more potent substances. Modifications at...

Dechloromethylation of the berberine to berberrubine — tricks to obtain pure product

Published Online: Jun 29, 2020

Page range: 98 - 101

DOI: https://doi.org/10.2478/acs-2020-0014

© 2020 Viktor Milata et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 Public License.