<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Cardiovascular diseases represent one of the most notable health problems of the modern civilization. Stroke and heart attack often lead to lethal outcome; essential problem underneath being thrombus formation. Prophylactic approaches include acetylsalicylic acid and clopidogrel therapy on the level of primary hemostasis, <italic>i.e</italic>., primary clot formation. In the last five years, in the USA, health care expenses related to cardiovascular diseases have increased 50 %, to over 350 billion dollars. Thus, application of plant species and medicinal plants rich in polyphenols in prevention of thrombus formation are of interest. This is supported by the fact that the number of publications on antiaggregatory effect of polyphenols has doubled in the last decade. In this review we focus on antiaggregatory effect of most abundant polyphenols – flavonoids, the effect of plant extracts rich in polyphenols (propolis, species <italic>Salvia</italic> sp., <italic>Calamintha nepeta</italic> L., <italic>Lavandula angustifolia</italic> Mill., <italic>Melissa officinalis</italic> L, <italic>Mentha x piperita</italic> L., <italic>Ocimum basilicum</italic> L., <italic>Origanum vulgare</italic> L., <italic>Rosmarinus officinalis</italic> L.) on platelet aggregation, association of chemical composition and antioxidant properties with the observed biological effect, and possible clinical significance of the published results.</p></abstract>

Cardiovascular diseases represent one of the most notable health problems of the modern civilization. Stroke and heart attack often lead to lethal outcome; essential problem underneath being thrombus formation. Prophylactic approaches include acetylsalicylic acid and clopidogrel therapy on the level of primary hemostasis, i.e., primary clot formation. In the last five years, in the USA, health care expenses related to cardiovascular diseases have increased 50 %, to over 350 billion dollars. Thus, application of plant species and medicinal plants rich in polyphenols in prevention of thrombus formation are of interest. This is supported by the fact that the number of publications on antiaggregatory effect of polyphenols has doubled in the last decade. In this review we focus on antiaggregatory effect of most abundant polyphenols – flavonoids, the effect of plant extracts rich in polyphenols (propolis, species Salvia sp., Calamintha nepeta L., Lavandula angustifolia Mill., Melissa officinalis L, Mentha x piperita L., Ocimum basilicum L., Origanum vulgare L., Rosmarinus officinalis L.) on platelet aggregation, association of chemical composition and antioxidant properties with the observed biological effect, and possible clinical significance of the published results.

Antithrombotic activity of flavonoids and polyphenols rich plant species

Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry

Faculty of Pharmacy and Biochemistry Department of Pharmaceutical Botany

Croatian Institute of Transfusion Medicine

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Antithrombotic activity of flavonoids and polyphenols rich plant species"}

Cardiovascular diseases represent one of the most notable health problems of the modern civilization. Stroke and heart attack often lead to lethal outcome;...

Antithrombotic activity of flavonoids and polyphenols rich plant species

Published Online: Oct 21, 2019

Page range: 483 - 495

Accepted: Jul 01, 2019

DOI: https://doi.org/10.2478/acph-2019-0050

Keywords
platelet aggregation, polyphenols, plant species, cardiovascular diseases

© 2019 Mirza Bojić et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Antithrombotic activity of flavonoids and polyphenols rich plant species

Published Online: Oct 21, 2019

Page range: 483 - 495

Accepted: Jul 01, 2019

DOI: https://doi.org/10.2478/acph-2019-0050

Keywordsplatelet aggregation, polyphenols, plant species, cardiovascular diseases

© 2019 Mirza Bojić et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
platelet aggregation, polyphenols, plant species, cardiovascular diseases