<abstract xmlns="http://www.w3.org/1999/xhtml"><p>There are several limited approaches to treat epilepsy in hospitals, for example, using medicines, surgery, electrical stimulation and dietary interventions. Despite the availability of all these new and old approaches, seizure is particularly difficult to manage. The quest for new antiepileptic molecules with more specificity and less CNS toxicity continues for medicinal chemists until a new and ideal drug arrives. This review covers new antiseizure molecules of different chemical classes, the exact mode of action of which is still unidentified. Newer agents include sulfonamides, thiadiazoles, semi- and thiosemicarbazones, pyrrolidine-2,5-diones, imidazoles, benzothiazoles and amino acid deriva tives. These new chemical entities can be useful for the design and development of forthcoming antiseizure agents.</p></abstract>

There are several limited approaches to treat epilepsy in hospitals, for example, using medicines, surgery, electrical stimulation and dietary interventions. Despite the availability of all these new and old approaches, seizure is particularly difficult to manage. The quest for new antiepileptic molecules with more specificity and less CNS toxicity continues for medicinal chemists until a new and ideal drug arrives. This review covers new antiseizure molecules of different chemical classes, the exact mode of action of which is still unidentified. Newer agents include sulfonamides, thiadiazoles, semi- and thiosemicarbazones, pyrrolidine-2,5-diones, imidazoles, benzothiazoles and amino acid deriva tives. These new chemical entities can be useful for the design and development of forthcoming antiseizure agents.

An overview of structurally diversified anticonvulsant agents

Department of Clinical Pharmacy College of Pharmacy

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"An overview of structurally diversified anticonvulsant agents"}

There are several limited approaches to treat epilepsy in hospitals, for example, using medicines, surgery, electrical stimulation and dietary interventions....

An overview of structurally diversified anticonvulsant agents

Published Online: Jun 26, 2019

Page range: 321 - 344

Accepted: Dec 15, 2018

DOI: https://doi.org/10.2478/acph-2019-0023

Keywords
antiepileptic agents, sulfonamides, imidazoles, thiadiazoles, benzothiazoles, amino acid derivatives

© 2019 Faisal Al-Otaibi, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

An overview of structurally diversified anticonvulsant agents

Published Online: Jun 26, 2019

Page range: 321 - 344

Accepted: Dec 15, 2018

DOI: https://doi.org/10.2478/acph-2019-0023

Keywordsantiepileptic agents, sulfonamides, imidazoles, thiadiazoles, benzothiazoles, amino acid derivatives

© 2019 Faisal Al-Otaibi, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
antiepileptic agents, sulfonamides, imidazoles, thiadiazoles, benzothiazoles, amino acid derivatives