<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Bigels with antifungal substances, ciclopirox olamine and terbinafine hydrochloride, were made of hydrogel (poloxamer 407 gel) and oleogel (polyethylene and liquid paraffin mixture). Prepared bigels were found physically stable at room temperature for six months and at least four months at 40 °C. Released amount of drug decreased when oleogel concentration in the formulation increased. Release test results depended on the insertion place of active substances. The amount of released substance was highest when ciclopirox olamine was incorporated in both phases in an equal quantity, and terbinafine hydrochloride in oleogel or in hydrogel. All formulations showed great inhibition of <italic>Microsporum canis</italic>. Thus, bigels with ciclopirox olamine and terbinafine hydrochloride are a promising dosage form for topical use.</p></abstract>

Bigels with antifungal substances, ciclopirox olamine and terbinafine hydrochloride, were made of hydrogel (poloxamer 407 gel) and oleogel (polyethylene and liquid paraffin mixture). Prepared bigels were found physically stable at room temperature for six months and at least four months at 40 °C. Released amount of drug decreased when oleogel concentration in the formulation increased. Release test results depended on the insertion place of active substances. The amount of released substance was highest when ciclopirox olamine was incorporated in both phases in an equal quantity, and terbinafine hydrochloride in oleogel or in hydrogel. All formulations showed great inhibition of Microsporum canis. Thus, bigels with ciclopirox olamine and terbinafine hydrochloride are a promising dosage form for topical use.

Topical antifungal bigels: Formulation, characterization and evaluation

Department of Clinical Pharmacy Faculty of Pharmacy

Department of Non-infectious Diseases, Faculty of Veterinary Medicine

Veterinary Academy Lithuanian University of Health Science

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Topical antifungal bigels: Formulation, characterization and evaluation"}

Bigels with antifungal substances, ciclopirox olamine and terbinafine hydrochloride, were made of hydrogel (poloxamer 407 gel) and oleogel (polyethylene and...

Topical antifungal bigels: Formulation, characterization and evaluation

Published Online: Apr 26, 2018

Page range: 223 - 233

Accepted: Dec 21, 2017

DOI: https://doi.org/10.2478/acph-2018-0014

Keywords
bigel, ciclopirox olamine, terbinafine hydrochloride, poloxamer 407, antifungal,

© 2018 Agne Mazurkeviciute et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Topical antifungal bigels: Formulation, characterization and evaluation

Published Online: Apr 26, 2018

Page range: 223 - 233

Accepted: Dec 21, 2017

DOI: https://doi.org/10.2478/acph-2018-0014

Keywordsbigel, ciclopirox olamine, terbinafine hydrochloride, poloxamer 407, antifungal,

© 2018 Agne Mazurkeviciute et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
bigel, ciclopirox olamine, terbinafine hydrochloride, poloxamer 407, antifungal,