<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The main objective of this study was to evaluate the influence of the formulation and process parameters on PLGA microparticles containing a practically insoluble model drug (ibuprofen) prepared by the o/w solvent evaporation method. Multivariate data analysis was used. The effects of altered stirring speed of a mechanical stirrer (600, 1000 rpm), emulsifier concentrations (PVA concentration 0.1 %, 1 %) and solvent selection (dichloromethane, ethyl acetate) on microparticle characteristics (encapsulation efficiency, drug loading, burst effect) were observed. It was found that with increased stirring speed, the PVA concentration or the use of ethyl acetate had a significantly negative effect on encapsulation efficiency. In addition, ethyl acetate had an adverse effect on the burst effect, while increased stirring speed had the opposite effect. Drug load was not affected by any particular variable, but rather by the interactions of evaluated variables.</p></abstract>

The main objective of this study was to evaluate the influence of the formulation and process parameters on PLGA microparticles containing a practically insoluble model drug (ibuprofen) prepared by the o/w solvent evaporation method. Multivariate data analysis was used. The effects of altered stirring speed of a mechanical stirrer (600, 1000 rpm), emulsifier concentrations (PVA concentration 0.1 %, 1 %) and solvent selection (dichloromethane, ethyl acetate) on microparticle characteristics (encapsulation efficiency, drug loading, burst effect) were observed. It was found that with increased stirring speed, the PVA concentration or the use of ethyl acetate had a significantly negative effect on encapsulation efficiency. In addition, ethyl acetate had an adverse effect on the burst effect, while increased stirring speed had the opposite effect. Drug load was not affected by any particular variable, but rather by the interactions of evaluated variables.

Influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis

Department of Pharmaceutics Faculty of Pharmacy University of Veterinary and Pharmaceutical Sciences, Brno 61242 Brno, Czech Republic

Department of Toxicology Pharmacology and Immunotherapy Veterinary Research Institute 62100 Brno, Czech Republic

Tescan, 62300 Brno-Kohoutovice Czech Republic

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The main objective of this study was to evaluate the influence of the formulation and process parameters on PLGA microparticles containing a practically...

Influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis

Published Online: Dec 20, 2014

Page range: 403 - 417

Accepted: Jun 16, 2014

DOI: https://doi.org/10.2478/acph-2014-0032

Keywords
solvent evaporation, encapsulation, PLGA, controlled release, burst effect

© by Kateřina Dvořáčková

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis

Published Online: Dec 20, 2014

Page range: 403 - 417

Accepted: Jun 16, 2014

DOI: https://doi.org/10.2478/acph-2014-0032

Keywordssolvent evaporation, encapsulation, PLGA, controlled release, burst effect

© by Kateřina Dvořáčková

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
solvent evaporation, encapsulation, PLGA, controlled release, burst effect