Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs

1. B. Albertini, N. Passerini, M. Di Sabatino, B. Vitali, P. Brigidi and L. Rodriguez, Polymer-lipid based mucoadhesive microspheres prepared by spray-congealing for the vaginal delivery of econazole nitrate, Eur. J. Pharm. Sci. 36 (2009) 591-601; DOI: 10.1016/j.ejps.2008.12.009.10.1016/j.ejps.2008.12.009Search in Google Scholar

2. J. A. Kamarashev and S. G. Vassileva, Dermatologic diseases of the vulva, Clin. Dermatol. 15 (1997) 53-65; DOI: 10.1016/j.bbr.2011.03.031.10.1016/j.bbr.2011.03.031Search in Google Scholar

3. R. Gurny, J. M. Meyer and N. A. Peppas, Bioadhesive intraoral release systems: design, testing and analysis, Biomaterials 5 (1984) 336-340; DOI: 10.1016/0142-9612(84)90031-0.10.1016/0142-9612(84)90031-0Search in Google Scholar

4. A. Bernkop-Schnürch and S. Dünnhaupt, Chitosan-based drug delivery systems, Eur. J. Pharm. Biopharm. 81 (2012) 463-469; DOI: 10.1016/j.ejpb.2012.04.007.10.1016/j.ejpb.2012.04.007Search in Google Scholar

5. C. Valenta, The use of mucoadhesive polymers in vaginal delivery, Adv. Drug Deliv. Rev. 57 (2005) 1692-1712; DOI: 10.1016/j.addr.2005.07.004.10.1016/j.addr.2005.07.004Search in Google Scholar

6. J. E. Codd and P. B. Deasy, Formulation development and in vivo evaluation of a novel bioadhesive lozenge containing a synergistic combination of antifungal agents, Int. J. Pharm. 173 (1998) 13-24; DOI: 10.1016/S0378-5173(98)00228-2.10.1016/S0378-5173(98)00228-2Search in Google Scholar

7. D. S. Jones, A. D. Woolfson and A. F. Brown, Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers, Int. J. Pharm. 151 (1997) 223-233; DOI: 10.1016/S0378-5173(97)04904-1.10.1016/S0378-5173(97)04904-1Search in Google Scholar

8. S. K. Yellanki, N. K. Nerella, S. Goranti and S. K. Deb, Development of metronidazole intravaginal gel for the treatment of bacterial vaginosis: Effect of mucoadhesive natural polymers on the release of metronidazole, Int. J. Pharm. Tech. Res. 2 (2010) 1746-1750.Search in Google Scholar

9. D. S. Jones, A. D. Woolfson and A. F. Brown, Textural analysis and flow rheometry of novel, bioadhesive antimicrobial oral gels, Pharm. Res. 14 (1997) 450-457; DOI: 10.1023/A: 1012091231023.Search in Google Scholar

10. G. P. Andrews, S. P. Gorman and D. S. Jones, Rheological characterisation of primary and binary interactive bioadhesive gels composed of cellulose derivatives designed as ophthalmic viscosurgical devices, Biomaterials 26 (2005) 571-580; DOI: 10.1016/j.biomaterials.2004.02.062.10.1016/j.biomaterials.2004.02.062Search in Google Scholar

11. D. S. Jones, A. D. Woolfson and J. Djokic, Texture profile analysis of bioadhesive polymeric semisolids: mechanical characterization and investigation of interactions between formulation components, J. Appl. Polym. Sci. 61 (1996) 2229-2234; DOI: 10.1002/(SICI)1097-4628(19960919)61.Search in Google Scholar

12. D. S. Jones, A. D. Woolfson, A. F. Brown, W. A. Coulter, C. McClelland and C. R. Irwin, Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease, J. Control. Release 67 (2000) 357-368; DOI: 10.1016/S0168-3659(00)00231-5.10.1016/S0168-3659(00)00231-5Search in Google Scholar

13. G. Sandri, M. C. Bonferoni, S. Rossi, F. Ferrari, M. Mori, C. Del Fante, C. Perotti, L. Scudeller and C. Caramella, Platelet lysate formulations based on mucoadhesive polymers for the treatment of corneal lesions, J. Pharm. Pharmacol. 63 (2011) 189-198; DOI: 10.1111/j.2042-7158.2010. 01208.x.Search in Google Scholar

14. C. E. Kast, C. Valenta, M. Leopold and A. Bernkop-Schnürch, Design and in vitro evaluation of a novel bioadhesive vaginal drug delivery system for clotrimazole, J. Control. Release 81 (2002) 347-354; DOI: 10.1016/S0168-3659(02)00077-9.10.1016/S0168-3659(02)00077-9Search in Google Scholar

15. N. A. Peppas, Analysis of fickian and non-fickian drug release polymers, Pharm. Acta Helv. 60 (1985) 110-111.Search in Google Scholar

16. P. L. Ritger and N. A. Peppas, A simple equation for description of solute release II. Fickian and anomalous release from swellable devices, J. Control. Release 5 (1987) 37-42; DOI: 10.1016/ 0168-3659(87)90035-6.10.1016/0168-3659(87)90035-6Search in Google Scholar

17. J. Parekh and S. Chanda, In vitro antimicrobial activity and phytochemical analysis of some Indian medicinal plants, Turk. J. Biol. 31 (2007) 53-58.Search in Google Scholar

18. X. He, J. Ma, A. E. Mercado, W. Xu and E. Jabbari, Cytotoxicity of paclitaxel in biodegradable self-assembled core-shell poly (lactide-co-glycolide ethylene oxide fumarate) nanoparticles, Pharm. Res. 25 (2008) 1552-1562; DOI: 10.1007/s11095-007-9513-z.10.1007/s11095-007-9513-zSearch in Google Scholar

19. K. Vermani and S. Garg, The scope and potential of vaginal drug delivery, PSTT 3 (2000) 359-364; DOI: 10.1016/S1461-5347(00)00296-0.10.1016/S1461-5347(00)00296-0Search in Google Scholar

20. S. Uppuluri, S. E. Keinath, D. A. Tomalia and P. R. Dvornic, Rheology of dendrimers. I. Newtonian flow behavior of medium and highly concentrated solutions of polyamidoamine (PAMAM) dendrimers in ethylenediamine (EDA) solvent, Macromolecules 31 (1998) 4498-4510; DOI: 10.1021/ ma971199b.10.1021/ma971199bSearch in Google Scholar

21. H. Qi, W. Chen, C. Huang, I. Li, C. Chen, W. Li and C. Wu, Development of a poloxamer analogs/ carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin, Int. J. Pharm. 337 (2007) 178-187; DOI: 10.1016/j.ijpharm.2006.12.038.10.1016/j.ijpharm.2006.12.038Search in Google Scholar

22. G. Dumortier, J. L. Grossiord, M. Zuber, G. Couarraze and J. C. Chaumeil, Rheological study of a thermoreversible morphine gel, Drug Dev. Ind. Pharm. 17 (1991) 1255-1265; DOI: 10.3109/ 03639049109043858.10.3109/03639049109043858Search in Google Scholar

23. K. Dillen, W. Weyenberg, J. Vandervoort and A. Ludwig, The influence of the use of viscosifiying agents as dispersion media on the drug release properties from PLGA nanoparticles, Eur. J. Pharm. Biopharm. 58 (2004) 539-549; DOI: 10.1016/j.ejpb.2004.03.035.10.1016/j.ejpb.2004.03.035Search in Google Scholar

24. W. Argüelles-Monal, F. M. Goycoolea, C. Peniche and I. Higuera-Ciapara, Rheological study of the chitosan/glutaraldehyde chemical gel system, Polym. Gels Netw. 6 (1998) 429-440; DOI: 10.1016/S0966-7822(98)00032-X.10.1016/S0966-7822(98)00032-XSearch in Google Scholar

25. D. S. Jones, A. D. Woolfson and A. F. Brown, Design, characterisation and preliminary clinical evaluation of a novel mucoadhesive topical formulation containing tetracycline for the treatment of periodontal disease, J. Control. Release 67 (2000) 357-368; DOI: 10.1016/S0168-3659(00) 00231-5.Search in Google Scholar

26. E. Baloglu, Z. Ay Senyigit, S. Y. Karavana and A. Bernkop-Schnürch, Strategies to prolong the intravaginal residence time of drug delivery systems, Pharm. Pharmac. Sci. 12 (2009) 312-336.Search in Google Scholar

27. S. Y. Karavana, Z. Ay Senyigit, S. Hilmioðlu-Polat, D. Y. Metin, O. Zekioðlu and E. Baloðlu, Mucoadhesive In situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis, Lat. Am. J. Pharm. 31 (2012) 821-829.Search in Google Scholar

28. J. Siepmann and N. A. Peppas, Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC), Adv. Drug Deliv. Rev. 48 (2001) 139-157; DOI: 10.1016/ S0169-409X(01)00112-0.10.1016/S0169-409X(01)00112-0Search in Google Scholar

29. A. A. Tayela, S. Moussa, W. F. El-Tras, D. Knittel, K. Opwis and E. Schollmeyer, Anticandidal action of fungal chitosan against Candida albicans, Int. J. Biol. Macromol. 47 (2010) 454-457; DOI: 10.1016/j.ijbiomac.2010.06.011.10.1016/j.ijbiomac.2010.06.01120603144Search in Google Scholar

30. R. Muzzarelli, R. Tarsi, O. Filippini, E. Giovanetti, G. Biagini and P. E. Varaldo, Antimicrobial properties of N-carboxybutyl chitosan, Antimicrob. Agents Chemother. 34 (1990) 2019-2023; DOI: 10.1128/AAC.34.10.2019.10.1128/AAC.34.10.2019Search in Google Scholar

31. A. R. Geonnotti, J. J. Peters and D. F. Katz, Erosion of microbicide formulation coating layers: effects of contact and shearing with vaginal fluid or semen, J. Pharm. Sci. 94 (2005) 1705-1712; DOI: 10.1002/jps.20386.10.1002/jps.20386Search in Google Scholar

32. K. Vermani, S. Garg and L. J. Zaneveld, Assemblies for in vitro measurement of bioadhesive strength and retention characteristics in simulated vaginal environment, Drug Dev. Ind. Pharm. 28 (2002) 1133-1146; DOI: 10.1081/DDC-120014580.10.1081/DDC-120014580Search in Google Scholar

33. B. E. Chatterton, S. Penglis, J. C. Kovacs, B. Presnell and B. Hunt, Retention and distribution of two 99mTc-DTPA labelled vaginal dosage forms, Int. J. Pharm. 271 (2004) 137-143; DOI: 10.1016/ j.ijpharm.2003.11.006. 10.1016/j.ijpharm.2003.11.006Search in Google Scholar

34. S. Y. Karavana, E. H. Gökçe, S. Rençber, S. Özbal, Ç. Pekçetin, P. Güneri and G. Ertan, A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: in vivo/in vitro examinations, Int. J. Nanomed. 7 (2012) 5693-5704; DOI: 10.2147/IJN.S36883.10.2147/IJN.S36883Search in Google Scholar

35. D. H. Owen, J. J. Peters and D. F. Katz, Rheological properties of contraceptive gels, Contraception 62 (2000) 321-326; DOI: 10.1016/S0010-7824(00)00184-0.10.1016/S0010-7824(00)00184-0Search in Google Scholar

36. S. Di Fabio, J. Van Roey, G. Giannini, G. van den Mooter, M. Spada, A. Binelli, M. F. Pirillo, E. Germinario, F. Belardelli, M. P. de Bethune and S. Vella, Inhibition of vaginal transmission of HIV-1 in hu-SCID mice by the non-nucleoside reverse transcriptase inhibitor TMC120 in a gel formulation, AIDS 17 (2003) 1597-1604; DOI: 10.1097/00002030-200307250-00003. 10.1097/00002030-200307250-0000312853741Search in Google Scholar