Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel for enhanced dermal delivery

1. U. Hoppe, J. Bergemann, W. Diembeck, J. Ennen, S. Gohla, I. Harris, J. Jacob, J. Kielholz, W. Mei, D. Pollet, D. Schachtschabel, G. Sauerman, V. Schreiner, F. Stäb and F. Steckel, Coenzyme Q10, a cutaneous antioxidant and energizer, Biofactors 9 (1999) 371-378.10.1002/biof.5520090238Search in Google Scholar

2. P. D. Forbes, Photocarcinogenesis: an overview, J. Invest. Dermatol. 77 (1981) 139-143; DOI: 10. 1111/1523-1747.ep12479351.10.1111/1523-1747.ep12479351Search in Google Scholar

3. M. Afzal, B. Matsugo, K. Aoyama and T. Takeuchi, Method to overcome photoreaction, a serious drawback to the use of dichlorofluorescin in evaluation of reactive oxygen species, Biochem. Biophys. Res. Commun. 304 (2003) 619-624; DOI: 10.1016/S0006-291X(03)00641-7.10.1016/S0006-291X(03)00641-7Search in Google Scholar

4. C. R. Murthy, K. V. Rama Rao, G. Bai and M. D. Norenberg, Ammonia-induced production of free radicals in primary cultures of rat astrocytes, J. Neurosci. Res. 66 (2001) 282-288; DOI: 10. 1002/jnr.1222.10.1002/jnr.122211592125Search in Google Scholar

5. S. Kumar, Free radicals and antioxidants: human and food system, Adv. Appl. Sci. Res. 2 (2011) 129-135.Search in Google Scholar

6. G. R. Lenaz, Fato, G. Formiggini and M. L. Genova, The role of Coenzyme Q in mitochondrial electron transport, Mitochondrion 7 (2007) Suppl:S8-S33; DOI: 10.1016/j.mito.2007.03.009.10.1016/j.mito.2007.03.00917485246Search in Google Scholar

7. K. Muta-Takada. T. Terada, H. Yamanishi, Y. Ashida, S. Inomata, T. Nishiyama and S. Amano, Coenzyme Q10 protects against oxidative stress-induced cell death and enhances the synthesis of basement membrane components in dermal and epidermal cells, Biofactors 35 (2009) 435-441; DOI: 10.1002/biof.56.10.1002/biof.5619753652Search in Google Scholar

8. V. Teeranachaideekul, E. B. Souto, V. B. Junyaprasert and R. H. Müller, Encapsulation of ascorbyl palmitate in nanostructured lipid carriers NLC - effects of formulation parameters on physicochemical stability, Int. J. Pharm. 340 (2007) 198-206; DOI: 10.1016/j.ijpharm.2007.03.022.10.1016/j.ijpharm.2007.03.02217482778Search in Google Scholar

9. E. B. Souto. S. A. Wissing, C. M. Barbosa and R. H. Müller, Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery, Int. J. Pharm. 278 (2004) 71-77; DOI: 10.1016/j.ijpharm.2004.02.032.10.1016/j.ijpharm.2004.02.03215158950Search in Google Scholar

10. E. H. Gokce, E. Korkmaz, E. Dellera, G. Sandri, M. C. Bonferoni and O. Ozer, Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications, Int. J. Nanomed. 7 (2012) 1841-1850; DOI: 10.2147%2FIJN.S29710.Search in Google Scholar

11. E. S. Farboud. S. A. Nasrollahi and Z. Tabbakhi, Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies, Int. J. Nanomed. 6 (2011) 611-617; DOI: 10.2147%2FIJN.S16815.Search in Google Scholar

12. K. Teskac and J. Kristl, The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol, Int. J. Pharm. 390 (2010) 61-69; DOI: 10.1016/j.ijpharm.2009.10.011.10.1016/j.ijpharm.2009.10.01119833178Search in Google Scholar

13. V. Jenning and S. H. Gohla, Encapsulation of retinoids in solid lipid nanoparticles (SLN), J. Microencapsul. 18 (2001) 149-158; DOI: 10.1080/02652040010000361.10.1080/0265204001000036111253932Search in Google Scholar

14. A. Dingler, R. P. Blum, H. Niehus, R. H. Muller and S. Gohla, Solid lipid nanoparticles (SLN/ Lipopearls)-a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products, J. Microencapsul. 16 (1999) 751-767; DOI: 10575627.10.1080/026520499288690Search in Google Scholar

15. V. Teeranachaideekul, E. B. Souto, V. B. Junyaprasert and R. H. Muller, Cetyl palmitate based NLC for topical delivery of Coenzyme Q(10) - development, physicochemical characterization and in vitro release studies, Eur. J. Pharm. Biopharm. 67 (2007) 141-148. DOI:10.1016/j.ejpb.2007.01.015.10.1016/j.ejpb.2007.01.015Search in Google Scholar

16. J. Liu, W. Hu, H. Chen, Q. Ni, H. Xu and X. Yang, Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery, Int. J. Pharm. 328 (2007) 191-195. DOI: 10.1016/j. ijpharm.2006.08.007.Search in Google Scholar

17. S. Y. Karavana, E. H. Gökçe, S. Rençber, S. Ozbal, C. Pekçetin, P. Güneri and G. Ertan, A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cy- closporine A solid lipid nanoparticles: in vivo/in vitro examinations, Int. J. Nanomed. 7 (2012) 5693-5704; DOI: 10.2147%2FIJN.S36883.10.2147/IJN.S36883Search in Google Scholar

18. D. S. Jones, M. L. Bruschi, O. de Freitas, M. P. Gremião, E. H. Lara and G. P. Andrews, Rheological, mechanical and mucoadhesive properties of thermoresponsive, bioadhesive binary mixtures composed of poloxamer 407 and carbopol 974P designed as platforms for implantable drug delivery systems for use in the oral cavity, Int. J. Pharm. 372 (2009) 49-58; DOI: 10.1016/j. ijpharm.2009.01.006.Search in Google Scholar

19. E. H. Gokce, E. Korkmaz, S. Tuncay-Tanriverdi, E. Dellera, G. Sandri, M. C. Bonferoni and O. Ozer, A comparative evaluation of coenzyme Q10-loaded liposomes and solid lipid nanoparticles as dermal antioxidant carriers, Int. J. Nanomed. 7 (2012) 5109-5117; DOI: 10.2147/IJN.S34921.10.2147/IJN.S34921Search in Google Scholar

20. J. Karpinska. B. Mikolu}, R. Motkowski and J. Piotrowska-Jastrzebska, HPLC method for simultaneous determination of retinol, alpha-tocopherol and coenzyme Q10 in human plasma, J. Pharm. Biomed. Anal. 18 (2006) 232-236; DOI: 10.1016/j.jpba.2006.03.037.10.1016/j.jpba.2006.03.037Search in Google Scholar

21. R. Re, N. Pellegrini and A. Proteggente, Antioxidant activity applying an improved ABTS radical cation decolorization assay, Free Radic. Biol. Med. 26 (1999) 1231-1237; DOI: 10.1016/S0891-5849(98)00315-3.10.1016/S0891-5849(98)00315-3Search in Google Scholar

22. E. H. Gokce, G. Sandri, M. C. Bonferoni, S. Rossi, F. Ferrari, T. Güneri and C. Caramella, Cyclosporine A loaded SLNs: evaluation of cellular uptake and corneal cytotoxicity, Int. J. Pharm. 364 (2008) 76-86; DOI: 10.1016/j.ijpharm.2008.07.028.10.1016/j.ijpharm.2008.07.028Search in Google Scholar

23. D. S. Jones, A. D. Woolfson and J. Djokic, Texture profile analysis of bioadhesive polymeric semisolids: mechanical characterization and investigation of interactions between formulation components, J. Appl. Polym. Sci. 61 (1996) 2229-2234; DOI: 10.1002/(SICI)1097-4628(19960919) 61:12<2229::AID-APP24>3.0.CO;2-0.Search in Google Scholar

24. D. S. Jones, A. D. Woolfson and A. F. Brown, Textural, viscoelastic and mucoadhesive properties of pharmaceutical gels composed of cellulose polymers, Int. J. Pharm. 151 (1997) 223-233; DOI: 10.1016/S0378-5173(97)04904-1.10.1016/S0378-5173(97)04904-1Search in Google Scholar

25. G. Bonacucina, M. Cepsi, M. Misici-Falzi and G. F. Palmieri, Rheological, adhesive and release characterisation of semisolid carbopol/tetraglycol systems, Int. J. Pharm. 307 (2005) 29-14; DOI: 10.1016/j.ijpharm.2005.09.034.10.1016/j.ijpharm.2005.09.034Search in Google Scholar

26. S. Tamburic and D. Q. M. Craig, Rheological evaluation of polyacrylic acid hydrogels, Pharm. Sci. 1 (1995) 107-109; DOI: 10.1111/j.2042-7158.1995.tb00403.x.Search in Google Scholar

27. J. Carlfors, K. Edsman, R. Petersson and K. Jörnving, Rheological evaluation of Gelrite® in situ gels for ophthalmic use, Eur. J. Pharm. Sci. 6 (1998) 113-119; DOI: 10.1016/S0928-0987(97)00074-2.10.1016/S0928-0987(97)00074-2Search in Google Scholar

28. W. Burchard and S. B. Ross-Murphy, Polymers and Gels, Elsevier Science Publishers, London 1990, pp. 15-23.Search in Google Scholar

29. L. Boulmedarat, J. L. Grossiord, E. Fattal and A. Bochot, Influence of methyl-b-cyclodextrin and liposomes on rheological properties of Carbopol® 974P NF gels, Int. J. Pharm. 254 (2003) 59-64; DOI: 10.1016/S0378-5173(02)00683-X.10.1016/S0378-5173(02)00683-XSearch in Google Scholar

30. H. Zhou, Y. Yue, G. Liu, Y. Li, J. Zhang, Z. Yan and M. Duan, Characterisation and skin distribution of lecithin-based coenzyme Q10-loaded lipid nanocapsules, Nanoscale Res. Lett. 20 (2010) 1561-1569; DOI: 10.1007/s11671-010-9677-z.10.1007/s11671-010-9677-z295603621076708Search in Google Scholar

31. D. R. Bickers and M. Athar, Oxidative stress in the pathogenesis of skin disease, J. Invest. Dermatol. 126 (2006) 2565-2575; DOI: 10.1038/sj.jid.5700340. 10.1038/sj.jid.570034017108903Search in Google Scholar