<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (<bold>4a-j</bold>). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.</p></abstract>

Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.

Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety

Department of Chemistry, Canara Engineering College, Benjanapadavu Mangalore-574219, Karnataka, India

PG Department of Medicinal Chemistry SDM College, Ujire-574240, Karnataka India

Acta Pharmaceutica

Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich...

Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety

Published Online: Jul 10, 2013

Page range: 231 - 239

DOI: https://doi.org/10.2478/acph-2013-0016

Keywords
imidazole derivatives, Mannich bases, oxadiazole, antibacterial activity, antifungal activity

This content is open access.

Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety

Published Online: Jul 10, 2013

Page range: 231 - 239

DOI: https://doi.org/10.2478/acph-2013-0016

Keywordsimidazole derivatives, Mannich bases, oxadiazole, antibacterial activity, antifungal activity

This content is open access.

Keywords
imidazole derivatives, Mannich bases, oxadiazole, antibacterial activity, antifungal activity