<abstract xmlns="http://www.w3.org/1999/xhtml"><p>This study aims to synthesize hybrid compounds “via” the coupling of sulphonamide and benzothiazole into one structure that may have improved antibacterial property. The N-(biphenyl-4-yl) thiourea (1) used for the synthesis of the targeted sulphonamides was obtained by reacting diphenylamine and ammonium thiocyanate at room temperature. Cyclization of N-(biphenyl-4-yl)thiourea gave 2-amino-6-phenylbenzothiazole (2) which reacted with benzenesulphonyl chloride and para-toulene sulphonyl chloride to give the targeted sulphonamides (3a &amp; 3b). The synthesized compounds were characterised using melting point, infra-red spectroscopy, nuclear magnetic resonance and elemental analysis. Anti-bacterial screening of the synthesised compounds indicated that all the compounds showed anti-bacterial properties, except 2-amino-6-phenylbenzothiazole that did not show any activity on <italic>Escherichia coli.</italic></p></abstract>

This study aims to synthesize hybrid compounds “via” the coupling of sulphonamide and benzothiazole into one structure that may have improved antibacterial property. The N-(biphenyl-4-yl) thiourea (1) used for the synthesis of the targeted sulphonamides was obtained by reacting diphenylamine and ammonium thiocyanate at room temperature. Cyclization of N-(biphenyl-4-yl)thiourea gave 2-amino-6-phenylbenzothiazole (2) which reacted with benzenesulphonyl chloride and para-toulene sulphonyl chloride to give the targeted sulphonamides (3a & 3b). The synthesized compounds were characterised using melting point, infra-red spectroscopy, nuclear magnetic resonance and elemental analysis. Anti-bacterial screening of the synthesised compounds indicated that all the compounds showed anti-bacterial properties, except 2-amino-6-phenylbenzothiazole that did not show any activity on Escherichia coli.

Synthesis And Antibacterial Activities Of Benzothiazole Derivatives Of Sulphonamides

Department of Veterinary Physiology and Pharmacology

Michael Okpara University of Agriculture Umudike

Acta Chemica Malaysia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

This study aims to synthesize hybrid compounds “via” the coupling of sulphonamide and benzothiazole into one structure that may have improved antibacterial...

Synthesis And Antibacterial Activities Of Benzothiazole Derivatives Of Sulphonamides

Published Online: Aug 03, 2020

Page range: 55 - 57

DOI: https://doi.org/10.2478/acmy-2020-0009

Keywords
Antibacterial, Benzothiazole Derivatives, Sulphonamide, Synthesis, Thiourea

© 2020 Chinyere B. C. Ikpa et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesis And Antibacterial Activities Of Benzothiazole Derivatives Of Sulphonamides

Published Online: Aug 03, 2020

Page range: 55 - 57

DOI: https://doi.org/10.2478/acmy-2020-0009

KeywordsAntibacterial, Benzothiazole Derivatives, Sulphonamide, Synthesis, Thiourea

© 2020 Chinyere B. C. Ikpa et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Antibacterial, Benzothiazole Derivatives, Sulphonamide, Synthesis, Thiourea