<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Mitral valve prolapse (MVP) represents a frequent cardiovascular condition associated with increased cardiovascular risk, which may have progressive course and become malignant. Dysregulation of autonomic nervous system - especially sympathetic overdrive – is one of the factors considered to play a key role in its aetiology and development. There is a growing evidence of a large impact of sympathetic system on the development of MVP. Exaggerated sympathetic activity may lead to morphologic changes in valves tissue such as thickening and redundancy. Nowadays, few investigative methods are known for evaluation of the regulatory state of sympathetic nervous system, which could be, theoretically, used to identify the subjects with sympathetic overactivity associated with an increased cardiovascular risk. Electrodermal activity or blood pressure variability represent promising non-invasive methods for evaluation of the regulatory outputs of sympathetic nervous system. There is a possibility to extend a set of investigative methods in MVP and include the monitoring of sympathetic activity in the assessment of cardiovascular risk. This article summarizes knowledge about pathogenesis, diagnostic and therapeutical approaches of MVP, and brings some novel insights on the parameters of autonomic nervous regulation, which haven’t yet been used in cardiovascular risk assessment in MVP.</p>
</abstract>

Mitral valve prolapse (MVP) represents a frequent cardiovascular condition associated with increased cardiovascular risk, which may have progressive course and become malignant. Dysregulation of autonomic nervous system - especially sympathetic overdrive – is one of the factors considered to play a key role in its aetiology and development. There is a growing evidence of a large impact of sympathetic system on the development of MVP. Exaggerated sympathetic activity may lead to morphologic changes in valves tissue such as thickening and redundancy. Nowadays, few investigative methods are known for evaluation of the regulatory state of sympathetic nervous system, which could be, theoretically, used to identify the subjects with sympathetic overactivity associated with an increased cardiovascular risk. Electrodermal activity or blood pressure variability represent promising non-invasive methods for evaluation of the regulatory outputs of sympathetic nervous system. There is a possibility to extend a set of investigative methods in MVP and include the monitoring of sympathetic activity in the assessment of cardiovascular risk. This article summarizes knowledge about pathogenesis, diagnostic and therapeutical approaches of MVP, and brings some novel insights on the parameters of autonomic nervous regulation, which haven’t yet been used in cardiovascular risk assessment in MVP.

Sympathetic nervous system and cardiovascular risk in mitral valve prolapse

Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava

Acta Medica Martiniana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Sympathetic nervous system and cardiovascular risk in mitral valve prolapse"}

Mitral valve prolapse (MVP) represents a frequent cardiovascular condition associated with increased cardiovascular risk, which may have progressive course and...

Sympathetic nervous system and cardiovascular risk in mitral valve prolapse

Published Online: Jul 27, 2019

Page range: 51 - 57

Received: Apr 18, 2019

Accepted: May 30, 2019

DOI: https://doi.org/10.2478/acm-2019-0007

Keywords
mitral valve prolapse, cardiovascular risk, sympathetic nervous system, electrodermal activity, blood pressure variability

© 2019 Bona Olexova L et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Sympathetic nervous system and cardiovascular risk in mitral valve prolapse

Published Online: Jul 27, 2019

Page range: 51 - 57

Received: Apr 18, 2019

Accepted: May 30, 2019

DOI: https://doi.org/10.2478/acm-2019-0007

Keywordsmitral valve prolapse, cardiovascular risk, sympathetic nervous system, electrodermal activity, blood pressure variability

© 2019 Bona Olexova L et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
mitral valve prolapse, cardiovascular risk, sympathetic nervous system, electrodermal activity, blood pressure variability