<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Drug resistant tuberculosis is a serious and increasing problem worldwide, particularly in countries with a high
incidence of tuberculosis and HIV infections. Resistant tuberculosis in children is usually due to the transmission
of resistant strains from the environment where they live. Most often it is a transfer from the parents, or other
relatives. A paucibacillary nature of the disease in children associated with difficulties in a collection of adequate
sputum samples means that the samples are often microscopically negative. If the cultivation is negative, any bacteriological
confirmation of the drug resistance is impossible. 
The aim of this study was to review current diagnostic and therapeutic principles in tuberculosis in children and
to demonstrate its incidence in population of the Slovak Republic during 2010-2012. 
We have retrospectively analyzed all children sputum samples from children with diagnosed tuberculosis in
Slovakia. The classical bacteriological analysis (culture on solid eggs-based media) was used to confirm the mycobacterium
tuberculosis infection and the proportion method was applied to test its susceptibility or resistance to
mostly used antituberculotics. 
In years 2010-2012, three cases of resistant form of tuberculosis have been diagnosed in Slovakia among 16 children
with cultivation positive to tuberculosis. In all of the cases the INH mono-resistance was confirmed (with the
same strains present in their relatives), suggesting primary resistance origin of infection. 
To ensure an appropriate and successful treatment of tuberculosis in children, accurate and timely diagnostics
and determination of susceptibility to anti-tuberculotics is essential.</p></abstract>

Drug resistant tuberculosis is a serious and increasing problem worldwide, particularly in countries with a high
incidence of tuberculosis and HIV infections. Resistant tuberculosis in children is usually due to the transmission
of resistant strains from the environment where they live. Most often it is a transfer from the parents, or other
relatives. A paucibacillary nature of the disease in children associated with difficulties in a collection of adequate
sputum samples means that the samples are often microscopically negative. If the cultivation is negative, any bacteriological
confirmation of the drug resistance is impossible. 
The aim of this study was to review current diagnostic and therapeutic principles in tuberculosis in children and
to demonstrate its incidence in population of the Slovak Republic during 2010-2012. 
We have retrospectively analyzed all children sputum samples from children with diagnosed tuberculosis in
Slovakia. The classical bacteriological analysis (culture on solid eggs-based media) was used to confirm the mycobacterium
tuberculosis infection and the proportion method was applied to test its susceptibility or resistance to
mostly used antituberculotics. 
In years 2010-2012, three cases of resistant form of tuberculosis have been diagnosed in Slovakia among 16 children
with cultivation positive to tuberculosis. In all of the cases the INH mono-resistance was confirmed (with the
same strains present in their relatives), suggesting primary resistance origin of infection. 
To ensure an appropriate and successful treatment of tuberculosis in children, accurate and timely diagnostics
and determination of susceptibility to anti-tuberculotics is essential.

Drug resistance to anti-tuberculotics in children - three years status in Slovakia

National Institute of Tuberculosis, Lung Diseases and Thoracic Surgery, Vysne Hagy

Department of
Pharmacology, Jessenius Faculty of Medicine in Martin, Comenius University, Slovak Republic

Acta Medica Martiniana

Drug resistant tuberculosis is a serious and increasing problem worldwide, particularly in countries with a high
incidence of tuberculosis and HIV infections....

Drug resistance to anti-tuberculotics in children - three years status in Slovakia

Published Online: Feb 25, 2014

Page range: 18 - 22

DOI: https://doi.org/10.2478/acm-2013-0018

Keywords
tuberculosis, children, resistance, anti-tuberculotics, Slovakia

This content is open access.

Drug resistance to anti-tuberculotics in children - three years status in Slovakia

Published Online: Feb 25, 2014

Page range: 18 - 22

DOI: https://doi.org/10.2478/acm-2013-0018

Keywordstuberculosis, children, resistance, anti-tuberculotics, Slovakia

This content is open access.

Keywords
tuberculosis, children, resistance, anti-tuberculotics, Slovakia