<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The discovery of mitochondria-derived peptides has facilitated a comprehensive understanding of their protective effects on various organs. One of such peptides, Mitochondrial ORF of the 12S rRNA type-C (MOTS-c), was initially characterized in 2015 as a bioactive molecule that regulates gene expression and cellular metabolism via 5’-adenosine monophosphate-activated protein kinase (AMPK).</p>
<p>MOTS-c has exhibited notable protective effects across diverse organs, including protection against diabetes, cardiovascular diseases, alleviating the impacts of ageing, and regulating the immune response. Despite these well-established functions, the precise role of MOTS-c in the endocrine system remains elusive. However, recent research emphasizes the increasing significance of MOTS-c and other mitochondrial-derived peptides in regulating endocrine system function and addressing metabolism-related diseases. Therefore, this review aims to summarize the current information on the action of MOTS-c and other mitochondrial--derived peptides in various endocrine system organs.</p>
</abstract>

The discovery of mitochondria-derived peptides has facilitated a comprehensive understanding of their protective effects on various organs. One of such peptides, Mitochondrial ORF of the 12S rRNA type-C (MOTS-c), was initially characterized in 2015 as a bioactive molecule that regulates gene expression and cellular metabolism via 5’-adenosine monophosphate-activated protein kinase (AMPK).
MOTS-c has exhibited notable protective effects across diverse organs, including protection against diabetes, cardiovascular diseases, alleviating the impacts of ageing, and regulating the immune response. Despite these well-established functions, the precise role of MOTS-c in the endocrine system remains elusive. However, recent research emphasizes the increasing significance of MOTS-c and other mitochondrial-derived peptides in regulating endocrine system function and addressing metabolism-related diseases. Therefore, this review aims to summarize the current information on the action of MOTS-c and other mitochondrial--derived peptides in various endocrine system organs.

Protective and multi-organ effects of MOTS-c and other mitochondrial-derived peptides in the endocrine system

Medical Journal of Cell Biology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

The discovery of mitochondria-derived peptides has facilitated a comprehensive understanding of their protective effects on various organs. One of such...

Protective and multi-organ effects of MOTS-c and other mitochondrial-derived peptides in the endocrine system

Published Online: Feb 24, 2024

Page range: 99 - 107

Received: Nov 22, 2023

Accepted: Nov 30, 2023

DOI: https://doi.org/10.2478/acb-2023-0017

Keywords
MOTS-c, MDPs, AMPK, endocrine system, metabolism

© 2023 Kacper Kamiński et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Protective and multi-organ effects of MOTS-c and other mitochondrial-derived peptides in the endocrine system

Published Online: Feb 24, 2024

Page range: 99 - 107

Received: Nov 22, 2023

Accepted: Nov 30, 2023

DOI: https://doi.org/10.2478/acb-2023-0017

KeywordsMOTS-c, MDPs, AMPK, endocrine system, metabolism

© 2023 Kacper Kamiński et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
MOTS-c, MDPs, AMPK, endocrine system, metabolism