Antioxidant Properties of Resveratrol and its Protective Effects in Neurodegenerative Diseases

[1] Albani D, Polito L, Batelli S, De Mauro S, Fracasso C, Martelli G et al. The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta(1-42)peptide. J. Neurochem. 2009; 110: 1445-1456.10.1111/j.1471-4159.2009.06228.xSearch in Google Scholar

[2] Amri A, Chaumeil JC, Sfa r S, Charrueau C. Administration of resveratrol: What formulation solutions to bioavailability limitations? J Control Release. 2012; 10; 158(2): 182-193.10.1016/j.jconrel.2011.09.083Search in Google Scholar

[3] Ashu J And Flint Beal M. Mitochondrial Dysfunction in Neurodegenerative Diseases. J Pharmacol Exp Ther. 2012; 342(3): 619-630.10.1124/jpet.112.192138Search in Google Scholar

[4] Balcerczyk A, Pirola L. Therapeutic potential of activators and inhibitors of sirtuins. BioFactors. 2010; 36(5): 383-393.10.1002/biof.112Search in Google Scholar

[5] Candelario-Jalil E, Slawik H, Ridelis I, Waschbischa, Akundi RS, Hull M, Fiebich BL. Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum. Journal of Molecular Neuroscience. 2005; 27(3): 303-310.10.1385/JMN:27:3:303Search in Google Scholar

[6] Canto C, Auwerx J. Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab. 2009; 7: 325-331.10.1016/j.tem.2009.03.008Search in Google Scholar

[7] Camont L, Cottart CH, Rhayem Y, Nivet-Antoine V, Djelidi R, Collin F, Beaudeux JL, Bonnefont- Rousselot D. Simple spectrophotometric assessment of the trans-/cis-resveratrol ratio in aqueous solutions. Anal Chim Acta. 2009; 634(1): 121-128.10.1016/j.aca.2008.12.003Search in Google Scholar

[8] Carrizzo A, Forte M, Damato A, Trimarco V, Salzano F, Bartolo M, Maciag A, Puca AA, Vecchione C. Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases. Food Chem Toxicol. 2013; 61: 215-226.10.1016/j.fct.2013.07.021Search in Google Scholar

[9] Catalgol B, Batirel S, Taga Y, Ozer NK. Resveratrol: French paradox revisited. Front Pharmacol. 2012; 3: 141.10.3389/fphar.2012.00141Search in Google Scholar

[10] Cao H, Pan X, Li C, Zhou C, Deng F, Li T. Density functional theory calculations for resveratrol. Bioorg Med Chem Lett. 2003; 13(11): 1869-1871.10.1016/S0960-894X(03)00283-XSearch in Google Scholar

[11] Caruso F, Tanski J, Villegas-Estrada A, Rossi M. Structural basis for antioxidant activity of trans-resveratrol: ab initio calculations and crystal and molecular structure. J Agric Food Chem. 2004; 52(24): 7279-7285.10.1021/jf048794e15563207Search in Google Scholar

[12] Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-{kappa}B signaling. J. Biol. Chem. 2005; 280: 40364-40374.Search in Google Scholar

[13] Chen CY, Jang JH, Li MH, Surh YJ. Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells. Biochem Biophys Res Commun. 2005; 331(4): 993-1000.10.1016/j.bbrc.2005.03.23715882976Search in Google Scholar

[14] Clark J, Silvaggi JM, Kiselak T, Zheng K, Clore EL, Dai Y, Bass CE, Simon DK. Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf. PLoS One. 2012; 7(11): e48925.10.1371/journal.pone.0048925349213323145024Search in Google Scholar

[15] Cordova-Gomez M, Galano A, Raul J, Alvarez-Idaboy JR. Piceatannol, a better peroxyl radical scavenger than resveratrol. RSC Advances. 2013; 3: 20209-20218.10.1039/c3ra42923gSearch in Google Scholar

[16] Donmez G, Wang D, Cohen DE, Guarente L. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell. 2010; 142: 320-332.10.1016/j.cell.2010.06.020291163520655472Search in Google Scholar

[17] Donmez G, Quteiro TF. SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol. Med. 2013; 5: 344-352.Search in Google Scholar

[18] Delmas D, Aires V, Limagne E, Dutatarte P, Mazue F, Ghiringhelli F, Latruffe N. Transport, stability, and biological activity of resveratrol. Ann N Y Acad Sci. 2011; 1215: 48-59.10.1111/j.1749-6632.2010.05871.x21261641Search in Google Scholar

[19] Delmas D, Jannin B, Latruffe N. Resveratrol: natural properties against atherosclerosis, associated pro-inflammatory effects and aging. Molecular Nutrition & Food Research. 2005, 49(5): 377-39510.1002/mnfr.20040009815830334Search in Google Scholar

[20] Dudka J, Gieroba R, Korga A, Burda n F, Matysiak W, Jodlowska-Jedrych B, Mandziuk S, Korobowicz E, Murias M. Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity. Evidence-Based Complementary and Alternative Medicine. 2012; Article ID 60618: 10.10.1155/2012/606183352248823258992Search in Google Scholar

[21] Feng Y, Wang XP, Yang SG, Wang YJ, Zhang X, Dua XT, Suna XX, Zhao M, Huang L, Liu RT . Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation. NeuroToxicology. 2009; 30(6): 986-995.10.1016/j.neuro.2009.08.01319744518Search in Google Scholar

[22] Franco SS, De Falco L, Ghaffa ri S, Brugnara C, Sinclair DA, Matte A, Iolascon A, Mohandas N, Bertoldi M, An X, Siciliano A, Rimmele P, Cappellini MD, Michan S, Zoratti E, Janin A, De Franceschi L. Resveratrol accelerates erythroid maturation by activation of FOXO3 and ameliorates anemia in beta-thalassemic mice. Haematologica. 2014; 99(2): 267-275.10.3324/haematol.2013.090076391295623975182Search in Google Scholar

[23] Fukui M, Yamabe N, Kang KS, Zhu BT. Growth-stimulatory effect of resveratrol in human cancer cells. Mol Carcinog. 2010; 49(8): 750-759.10.1002/mc.2065020572158Search in Google Scholar

[24] Gao J, Wang WY, Mao YW, Graff J, Guan JS, Pan L. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature. 2010; 466: 1105-1109.10.1038/nature09271292887520622856Search in Google Scholar

[25] Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV Jr, Alt FW, Kahn CR, Verdin E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010; 464(7285): 121-125.10.1038/nature08778284147720203611Search in Google Scholar

[26] Holthoff JH, Woodling KA, Doerge DR, Burns ST, Hinson JA, Mayeux PR. Resver at r ol , a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite. Biochem Pharmacol. 2010; 80(8): 1260-1265.10.1016/j.bcp.2010.06.027293487320599800Search in Google Scholar

[27] Hurst WJ, Glinski JA, Miller KB, Apgar J, Davey MH, Stuart DA. Survey of the trans-resveratrol and trans-piceid content of cocoa-containing and chocolate products. J Agric Food Chem. 2008; 24: 56(18): 8374-8378.10.1021/jf801297w18759443Search in Google Scholar

[28] Hussein Mohammed A. A Convenient Mechanism for the Free Radical Scavenging Activity of Resveratrol, International Journal of Phytomedicine. 2011; 3: 459-469.Search in Google Scholar

[29] Iuga C, Alvarez-Idaboy JR, Russo N. Antioxidant activity of trans-resveratrol toward hydroxyl and hydroperoxyl radicals: a quantum chemical and computational kinetics study. J Org Chem. 2012; 77(8): 3868-3877.10.1021/jo300213422475027Search in Google Scholar

[30] Iwahara T, Bonasio R, Narendra V, Reinberg D. SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol.Cell.Biol. 2012; 32: 5022-5034.Search in Google Scholar

[31] Jensen JS, Wertz CF, O‘neill VA. Preformulation stability of trans-resveratrol and trans-resveratrol glucoside (Piceid). J Agric Food Chem. 2010; 58(3): 1685-1690.10.1021/jf903009f20055412Search in Google Scholar

[32] Juan ME, Gonzalez-Pons E, Munuera T, Ballester J, Rodriguez-Gil JE, Planas JM. Trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats. J Nutr. 2005; 135(4): 757-760.10.1093/jn/135.4.75715795430Search in Google Scholar

[33] Julien C, Tremblay C, Emond V, Lebbadi M, Salem N Jr., Bennett DA. Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J. Neuropathol. Exp. Neurol. 2009; 68: 48-58.Search in Google Scholar

[34] Karuppag ounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer’s disease. Neurochem Int. 2009; 54(2): 111-118.10.1016/j.neuint.2008.10.008289290719041676Search in Google Scholar

[35] Kavas GO, Ayral PA, Elhan AH. The Effects of Resveratrol on Oxidant/Antioxidant Systems and Their Cofactors in Rats. Adv Clin Exp Med. 2013; 22(2): 151-155.Search in Google Scholar

[36] Kincaidand B, Bossy-Wetzel. Forever young: SIRT3 a shield against mitochondrial melt down, aging, and neurodegeneration. Frontiers in aging neurodegenearation. Front Aging Neurosci. 2013; 5: 48.Search in Google Scholar

[37] Kopeć A, Piątkowska E, Leszczyńska T, Bieżanowska-Kopeć R. Health-promoting affects of resveratrol [in Polish]. ŻYWNOŚĆ. Nauka. Technologia. Jakość. 2011; 5(78): 5-15 Search in Google Scholar

[38] Krstic D, Knuesel I. Deciphering the mechanism underlying late-onset Alzheimer disease. Nat. Rev. Neurol. 2013; 9: 25-34.Search in Google Scholar

[39] Ladiwala AR, Lin JC, Bale SS, Marcelino-Cruz AM, Bhattacharya M, Dordcik JS, Tessier PM. Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers. J Biol Chem. 2010; 285(31): 24228-24237.10.1074/jbc.M110.133108291134920511235Search in Google Scholar

[40] Li Y, Cao Z, Zhu H. Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress. Pharmacol. Res. 2006; 53: 6-15.Search in Google Scholar

[41] Li F, Gong Q, Dong H, Shi J. Resveratrol, A Neuroprotective Supplement for Alzheimer’s Disease. Curr Pharm Des. 2012; 18(1): 27-33.10.2174/13816121279891907522211686Search in Google Scholar

[42] Lin TK, Chen SD, Chuang YC, Lin HY, Huang CR, Chuang JH, Wang PW, Huang SH, Tiao MM, Chen JB, Liou CW. Resveratrol Partially Prevents Rotenone-Induced Neurotoxicity in Dopaminergic SH-SY5Y Cells through Induction of Heme Oxygenase-1 Dependent Autophagy. Int J Mol Sci. 2014; 15(1): 1625-1646.10.3390/ijms15011625390789024451142Search in Google Scholar

[43] Ludolph AC, Kassubek J, Landwehrmeyer BG, Mandelkow E, Mandelkow EM, Burn DJ. Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options. Eur.J.Neurol. 2009; 16: 297-309.Search in Google Scholar

[44] Mahal Hs, Mukherjee. Scavenging of reactive oxygen radicals by resveratrol: antioxidant effect. Research on Chemical Intermediates. 2006; 32(1): 59-71.10.1163/156856706775012941Search in Google Scholar

[45] Marabaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer’s disease amyloid-beta peptides. J Biol Chem. 2005; 280(45): 37377-37382.10.1074/jbc.M50824620016162502Search in Google Scholar

[46] Martin OJ, Lai L, Soundarapa ndian MM, Leone TC, Zorzano A, Keller MP, Attie AD Muoio DM, Kelly DP. A Role for Peroxisome Proliferator-Activated Receptor γ Coactivator-1 in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth. Circ Res. 2014; 114(4): 626-636.10.1161/CIRCRESAHA.114.302562406176824366168Search in Google Scholar

[47] Mccall CE, Elgazzar M, Liu T, Vachharajani V, Yoza B. Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprograming during acute systemic inflammation. J. Leukoc.Biol. 2011; 90: 439-446.Search in Google Scholar

[48] Medzhitov R, Horng T. Transcriptional control of the inflammatory response. Nat.Rev.Immunol. 2009; 9: 692-703.Search in Google Scholar

[49] Michan S, Sinclair. Sirtuins in mammals: insights into their biological function. Biochem J. 2007; 404(1): 1-13.10.1042/BJ20070140275345317447894Search in Google Scholar

[50] Mikstacka R, Ignatowicz E. Chemopreventive and therapeutic affects of trans-resveratrol and its analogues in neoplastic diseases [in Polish]. Pol Merk Lek 2010; 168: 496-500.Search in Google Scholar

[51] Miller NJ, Rice-Evans CA. Antioxidant activity of resveratrol in red wine. Clinical Chemistry. 1995; 41: 1789.10.1093/clinchem/41.12.1789Search in Google Scholar

[52] Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010; 67: 953-966.10.1016/j.neuron.2010.08.044303510320869593Search in Google Scholar

[53] Min SW, Sohn PD, Cho SH, Swanson RA, Gan L. Sirtuins in neurodegenerative diseases: an update on potential mechanisms. Front Aging Neurosci. 2013; 5: 53.10.3389/fnagi.2013.00053378264524093018Search in Google Scholar

[54] Mokni M, Elkahoui S, Limam F, Amri M, Aouani E. Effect of Resveratrol on Antioxidant Enzyme Activities in the Brain of Healthy Rat. Neurochemical Research. 2007; 32; 6: 981-987.10.1007/s11064-006-9255-z17401679Search in Google Scholar

[55] Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell. 2009; 137(3): 560-570.10.1016/j.cell.2009.02.026269866619410549Search in Google Scholar

[56] Ng F, Tang BL. Sirtuins’ modulation of autophagy. J Cell Physiol. 2013; 228(12): 2262-70.10.1002/jcp.2439923696314Search in Google Scholar

[57] Olas B. Resveratrol as a benefactor in prophylaxis of diseases in circulatory system [in Polish]. Kosmos problemy nauk biologicznych, Polskie Towarzystwo Przyrodników im. Kopernika. 2006; 55, 2-3: 271-272.Search in Google Scholar

[58] Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofa lo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem. 2010; 285(11): 8340-8351 10.1074/jbc.M109.088682283298420061378Search in Google Scholar

[59] Park SJ, Ahmad F, Philp A, Baar K, Williams T, Lou H, Ke H, Rehmann H, Taussig R, Brown, et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 2012; 148: 487-501.10.1016/j.cell.2012.01.017343180122304913Search in Google Scholar

[60] Pope D, Madura JD, Cascio. M. β-Amyloid and Neprilysin Computational Studies Identify Critical Residues Implicated in Binding Specificity. J. Chem. Inf. Model. 2014.10.1021/ci500015m24650257Search in Google Scholar

[61] Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab. 2010; 12: 662-667.10.1016/j.cmet.2010.11.01521109198Search in Google Scholar

[62] Quincozes-Santos A, Gottfried C. Resveratrol modulates astroglial functions: neuroprotective hypothesis. Ann N Y Acad Sci. 2011; 1215: 72-78.10.1111/j.1749-6632.2010.05857.x21261643Search in Google Scholar

[63] Richard T, Pawlus AD, Iglesias ML, Pedrot E,Waffo-Teguo P,Merillon JM, Monti JP. Neuroprotective properties of resveratrol and derivatives. Ann N Y Acad Sci. 2011; 1215: 103-108.10.1111/j.1749-6632.2010.05865.x21261647Search in Google Scholar

[64] Riederer BM, Leuba G, Vernay A, Riederer IM. The role of the ubiquitin proteasome system in Alzheimer’s disease. Exp Biol Med (Maywood). 2011; 236(3): 268-76.10.1258/ebm.2010.01032721383047Search in Google Scholar

[65] Robb EL, Page MM, Wiens BE, Stuart JA. Molecular mechanisms of oxidative stress resistance induced by resveratrol: Specific and progressive induction of MnSOD. Biochem. Biophys. Res. Commun. 2008; 367: 406-412.Search in Google Scholar

[66] Rocha KK, Souza GA, Ebaid GX, Seiva FR, Cantaneo AC, Novelli EL. Resveratrol toxicity: effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets. Food Chem Toxicol. 2009; 47(6): 1362-1367.10.1016/j.fct.2009.03.01019298841Search in Google Scholar

[67] Rodacka A, Strumillo J, Serafin E, Puchala M. Effect of Resveratrol and Tiron on The Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase Induced by Superoxide Anion Radical. Curr Med Chem. 2014; 21(8):1061-1069.10.2174/0929867311320666027424059224Search in Google Scholar

[68] Rovilllain E, Mansfield L, Caetano C, Alvarez-Fernandez M, Caballero OL, Medema Rh et al. Activation of nuclear factor-kappaB signalling promotes cellular senescence. Oncogene 2011; 30: 2356-2366.10.1038/onc.2010.611308081121242976Search in Google Scholar

[69] Ryan MJ, Jackson JR, Hao Y, Williamson CL, Dabkowski ER, Hollander JM, Alway SE. Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice. J Gerontol A Biol Sci Med Sci. 2010; 65(8): 815-831.10.1093/gerona/glq080290378620507922Search in Google Scholar

[70] Saunders LR, Verdin E. Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene. 2007; 26: 5489-5504.10.1038/sj.onc.121061617694089Search in Google Scholar

[71] Scapag nini G, Vasto S, Abraham NG, Caruso C, Zella D, Fabio G. Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders. Mol Neurobiol. 2011; 44(2): 192-201.10.1007/s12035-011-8181-5555493821499987Search in Google Scholar

[72] Seo AY, Joseph AM, Dutta D, Hwang JCY, Aris JP, Leeuwenburgh C. New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J. Cell Sci. 2010; 123: 2533-2542.10.1242/jcs.070490291246120940129Search in Google Scholar

[73] Son Y, Lee JH, Chung HT, Pae HO. Therapeutic Roles of Heme Oxygenase-1 in Metabolic Diseases: Curcumin and Resveratrol Analogues as Possible Inducers of Heme Oxygenase-1. Oxid Med Cell Longev. 2013; 639541.10.1155/2013/639541378651624101950Search in Google Scholar

[74] Spa nier G, Xu H, Xia N, Tobias S, Deng S, Wojnowski L, Forstermann U, Li H. Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J Physiol Pharmacol. 2009; 60(4): 111-116.Search in Google Scholar

[75] Strumiłło J, Rodacka A, Puchała M. Relationship between structural lack of order and function in inherently unordered proteins [in Polish]. Postępy Biologii Komórki. 2013; 40(4): 602-627.Search in Google Scholar

[76] Sueishi Y, Hori M. Nitric oxide scavenging rates of solubilized resveratrol and flavonoids. Nitric Oxide. 2013; 29: 25-29.10.1016/j.niox.2012.12.00223246439Search in Google Scholar

[77] Szewczuk LM, Forti L, Stivalala, Penning TM. Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem. 2004; 279(21): 22727-22737.10.1074/jbc.M31430220015020596Search in Google Scholar

[78] Tadolini B, Juliano C, Piu L, Franconi F, Cabrini L. Resveratrol inhibition of lipid peroxidation. Free Radic Res. 2000; 33(1): 105-114 10.1080/1071576000030066110826926Search in Google Scholar

[79] Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H et al. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol.Cell. 2010; 40: 893-904.Search in Google Scholar

[80] Tennen RI, Michishita-Kioi E, Chua KF. Finding a Target for Resveratrol. Cell. 2012; 148, 3: 387-389.Search in Google Scholar

[81] Trela BC, Waterhouse AL. Resver at r ol : Isomeric molar absorbivities and stability. J. Agric. Food Chem. 1996; 44: 1253-1257.10.1021/jf9504576Search in Google Scholar

[82] Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T, Bober E. Sirt 7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ Res. 2008; 102(6): 703-710.10.1161/CIRCRESAHA.107.16455818239138Search in Google Scholar

[83] Van Ham TJ, Thijssen KL, Breitling R, Hofstra RM, Plasterek RH, Nollen EA. C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoSGenet. 2008; 4(3): e1000027.10.1371/journal.pgen.1000027226541218369446Search in Google Scholar

[84] Vang O, Ahmad N, Baile CA, Baur JA, Brown K, Csiszar A, Das DK, Delmas D, Gottfried C, Lin HY, Ma QY, Mukhopad hyay P, Nalini N, Pezzuto JM, Richard T, Shukla Y, Surh YJ, Szekeres T, Szkudelski T, Walle T, Wu JM. What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PloS One. 2011; 6(6): 19881.10.1371/journal.pone.0019881311682121698226Search in Google Scholar

[85] Vian MA, Tomao V, Gallet S, Coulomb PO, Lacombe JM. Simple and rapid method for cis- and trans- resveratrol and piceid isomers determination in wine by high-performance liquid chromatography using chromolith columns. J Chromatogr A. 2005; 2, 1085(2): 224-229.Search in Google Scholar

[86] Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science. 2009; 323: 1063-1066.10.1126/science.1165946342934919229036Search in Google Scholar

[87] Wu PF, Xie N, Zhang JJ, Guan XL, Zjou J, Long LH, Li YL, Xiong QJ, Zeng JH, Wang F, Chen JG. Resveratrol preconditioning increases methionine sulfoxide reductases A expression and enhances resistance of human neuroblastoma cells to neurotoxins. J Nutr Biochem. 2013; 24(6): 1070-1077.10.1016/j.jnutbio.2012.08.00523022493Search in Google Scholar

[88] Yang J, Wang N, Li J, Zhang J, Feng P. Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells. Endocrine. 2010; 37(2): 365-372.10.1007/s12020-010-9314-820960276Search in Google Scholar

[89] Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA et al. Modulation of NF-kBdependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 2004; 23: 2369-2380.10.1038/sj.emboj.760024442328615152190Search in Google Scholar

[90] Yu LY , Wu ML, Li H, Chen XY, Wang Q, Sun Y, Kong QY, Liu J. Inhibition of STAT3 Expression and Signaling in Resveratrol-Differentiated Medulloblastoma Cells. Neoplasia. 2008; 10(7): 736-744.10.1593/neo.08304243500918592012Search in Google Scholar

[91] Zhong L, D’urso A, Toiber D, Sebastian C, Henry RE, Vaddysirisack DD, Guimaraes A, Marinelli B, Wiksstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW , Espinosa JM, Mostoslavsky R. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 2010; 140(2): 280-293 10.1016/j.cell.2009.12.041282104520141841Search in Google Scholar