<abstract xmlns="http://www.w3.org/1999/xhtml"><p>In December 2019, an unexpected interaction of coronavirus with human’s occurred for the third time in history after Severe Acute Respiratory Syndrome (SARS) in 2002-2003 and Middle East Respiratory Syndrome (MERS) in 2012. Soon the virus was confirmed as SARS-CoV-2, and the severity of its transmission lead the World Health Organization to declare it as World Pandemic. Due to its highly contagious nature, new methods like social distancing, self-hygiene and quarantine were being adopted by many countries to halt the transmission. Due to the dearth in specific therapeutics and/or vaccines against Coronavirus Disease (COVID-19), a significant thrust in drugs and vaccine discovery was ratified by all the nations. The current review comprehensively details about the emergence and molecular pathogenesis with an interesting timeline which notes all the major events during this crisis. Given the potential general readers and health workers, the symptoms and diagnostic approaches were simplified. Emphasis was given to therapeutic approaches and clinical trials section to support the translational research and to cope up with the viral outbreak.</p></abstract>

In December 2019, an unexpected interaction of coronavirus with human’s occurred for the third time in history after Severe Acute Respiratory Syndrome (SARS) in 2002-2003 and Middle East Respiratory Syndrome (MERS) in 2012. Soon the virus was confirmed as SARS-CoV-2, and the severity of its transmission lead the World Health Organization to declare it as World Pandemic. Due to its highly contagious nature, new methods like social distancing, self-hygiene and quarantine were being adopted by many countries to halt the transmission. Due to the dearth in specific therapeutics and/or vaccines against Coronavirus Disease (COVID-19), a significant thrust in drugs and vaccine discovery was ratified by all the nations. The current review comprehensively details about the emergence and molecular pathogenesis with an interesting timeline which notes all the major events during this crisis. Given the potential general readers and health workers, the symptoms and diagnostic approaches were simplified. Emphasis was given to therapeutic approaches and clinical trials section to support the translational research and to cope up with the viral outbreak.

COVID-19: A Centennial Pandemic from Origin to Clinical Trials

Acta Biologica Marisiensis

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"COVID-19: A Centennial Pandemic from Origin to Clinical Trials"}

In December 2019, an unexpected interaction of coronavirus with human’s occurred for the third time in history after Severe Acute Respiratory Syndrome (SARS)...

COVID-19: A Centennial Pandemic from Origin to Clinical Trials

Published Online: Jun 29, 2020

Page range: 30 - 52

Received: May 18, 2020

Accepted: Jun 10, 2020

DOI: https://doi.org/10.2478/abmj-2020-0003

Keywords
COVID-19, Coronavirus, Clinical trials, Pandemic, Infection

© 2020 Ruddhida R Vidwans et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

COVID-19: A Centennial Pandemic from Origin to Clinical Trials

Published Online: Jun 29, 2020

Page range: 30 - 52

Received: May 18, 2020

Accepted: Jun 10, 2020

DOI: https://doi.org/10.2478/abmj-2020-0003

KeywordsCOVID-19, Coronavirus, Clinical trials, Pandemic, Infection

© 2020 Ruddhida R Vidwans et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
COVID-19, Coronavirus, Clinical trials, Pandemic, Infection