<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Background: Renal microvascular disease and reduction in peritubular capillary flow are generally observed in type 2 diabetic nephropathy (DN). Earlier therapeutic strategy with vasodilators has improved renal function in normo-albuminuric type 2 DN. Objective: Study the mechanism of vascular homeostasis in twenty patients associated with normo-albuminuric type 2 DN. Results: Angiogenic factors were observed in normo-albuminuric type 2 DN, where vascular endothelial growth factor (VEGF), was 420 ± 341 vs. 428±291 pg/mL (normal), and vascular endothelial growth factor - receptor 1 (VEGF-R1) was 60±12 vs. 49±5 ng/mL (normal), which were not significantly different from the controls. Anti-angiogenic factors were observed in normo-albuminuric type 2 DN, where angiopoietin-2, was 2309+1125 vs. 1671±835 pg/mL (normal), and vascular endothelial growth factor - receptor 2 (VEGF-R2) was 5715±1400 vs.6126 ±1060 ng/mL (normal), which were not significantly different from the controls. Conclusion: The mechanism of vascular homeostasis was adequately functional in normo-albuminuric type 2 DN. This mechanism may explain the positive response to vasodilators and improved renal function in early stage of type 2 DN following the vasodilator treatment.</p></abstract>

Background: Renal microvascular disease and reduction in peritubular capillary flow are generally observed in type 2 diabetic nephropathy (DN). Earlier therapeutic strategy with vasodilators has improved renal function in normo-albuminuric type 2 DN. Objective: Study the mechanism of vascular homeostasis in twenty patients associated with normo-albuminuric type 2 DN. Results: Angiogenic factors were observed in normo-albuminuric type 2 DN, where vascular endothelial growth factor (VEGF), was 420 ± 341 vs. 428±291 pg/mL (normal), and vascular endothelial growth factor - receptor 1 (VEGF-R1) was 60±12 vs. 49±5 ng/mL (normal), which were not significantly different from the controls. Anti-angiogenic factors were observed in normo-albuminuric type 2 DN, where angiopoietin-2, was 2309+1125 vs. 1671±835 pg/mL (normal), and vascular endothelial growth factor - receptor 2 (VEGF-R2) was 5715±1400 vs.6126 ±1060 ng/mL (normal), which were not significantly different from the controls. Conclusion: The mechanism of vascular homeostasis was adequately functional in normo-albuminuric type 2 DN. This mechanism may explain the positive response to vasodilators and improved renal function in early stage of type 2 DN following the vasodilator treatment.

Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy"}

Background: Renal microvascular disease and reduction in peritubular capillary flow are generally observed in type 2 diabetic nephropathy (DN). Earlier...

Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy

Published Online: Apr 13, 2018

Page range: 987 - 990

DOI: https://doi.org/10.2478/abm-2010-0132

Keywords
Enhanced renal perfusion, normo-albuminuric type 2 diabetic nephropathy, vascular homeostasis, restoring renal function

© 2018

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Vascular homeostasis in early (normo-albuminuric) type 2 diabetic nephropathy

Published Online: Apr 13, 2018

Page range: 987 - 990

DOI: https://doi.org/10.2478/abm-2010-0132

KeywordsEnhanced renal perfusion, normo-albuminuric type 2 diabetic nephropathy, vascular homeostasis, restoring renal function

© 2018

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Enhanced renal perfusion, normo-albuminuric type 2 diabetic nephropathy, vascular homeostasis, restoring renal function