Open Access

Effect of cyproheptadine on weight gain in malnourished children: a randomized, controlled trial


Cite

1. Food and Drug Administration of Thailand. National list of essential medicine. [cited Dec 12 2009]. Available from: http://www.thaifda.com/ed2547/.Search in Google Scholar

2. Homnick DN, Marks JH, Hare KL, Bonnema SK. Long-term trial of cyproheptadine as an appetite stimulant in cystic fibrosis. Pediatr Pulmonol. 2005; 40: 251-6.10.1002/ppul.20265Search in Google Scholar

3. Bruera E. Current pharmacological management of anorexia in cancer patients. Oncology (Williston Park). 1992; 6:125-30; discussion: 32, 37.Search in Google Scholar

4. Jatoi A, Loprinzi CL. An update: cancer-associated anorexia as a treatment target. Curr Opin Clin Nutr Metab Care. 2001; 4:179-82.10.1097/00075197-200105000-00002Open DOISearch in Google Scholar

5. Mattox TW. Treatment of unintentional weight loss in patients with cancer. Nutr Clin Pract. 2005; 20: 400-10.10.1177/0115426505020004400Search in Google Scholar

6. Mao X, Liang SB, Hurren R, Gronda M, Chow S, Xu GW, et al. Cyproheptadine displays preclinical activity in myeloma and leukemia. Blood. 2008; 112: 760-9.10.1182/blood-2008-02-142687Search in Google Scholar

7. Powers PS, Santana C. Available pharmacological treatments for anorexia nervosa. Expert Opin Pharmacother. 2004; 5:2287-92.10.1517/14656566.5.11.2287Search in Google Scholar

8. Balog DL, Epstein ME, Amodio-Groton MI. HIV wasting syndrome: treatment update. Ann Pharmacother. 1998; 32:446-58.10.1345/aph.17072Search in Google Scholar

9. Aguilera A, Selgas R, Diez JJ, Bajo MA, Codoceo R, Alvarez V. Anorexia in end-stage renal disease: pathophysiology and treatment. Expert Opin Pharmacother. 2001; 2:1825-38.10.1517/14656566.2.11.1825Search in Google Scholar

10. World Health Organization. Physical status: the use and interpretation of anthropometry. Report of a WHO expert committee. Technical Report Series No. 854. Geneva:WHO, 1995.Search in Google Scholar

11. Mahachoklertwattana P, Wanasuwankul S, Poomthavorn P, Choubtum L, Sriphrapradang A. Shortterm cyproheptadine therapy in underweight children: effects on growth and serum insulin-like growth factor- I. J Pediatr Endocrinol Metab. 2009; 22:425-32.10.1515/JPEM.2009.22.5.425Search in Google Scholar

12. Kaplowitz PB, Jennings S. Enhancement of linear growth and weight gain by cyproheptadine in children with hypopituitarism receiving growth hormone therapy. J Pediatr. 1987; 110:140-3.10.1016/S0022-3476(87)80310-4Search in Google Scholar

13. Couluris M, Mayer JL, Freyer DR, Sandler E, Xu P, Krischer JP. The effect of cyproheptadine hydrochloride (periactin) and megestrol acetate (megace) on weight in children with cancer/treatmentrelated cachexia. J Pediatr Hematol Oncol. 2008; 30: 791-7.10.1097/MPH.0b013e3181864a5e291779118989154Open DOISearch in Google Scholar

14. Heyward VH. Practical body composition assessment for children, adults, and older adults. Int J Sport Nutr. 1998; 8:285-307.10.1123/ijsn.8.3.285Search in Google Scholar

15. Sung RY, So HK, Choi KC, Li AM, Yin J, Nelson EA. Body fat measured by bioelectrical impedance in Hong Kong Chinese children. Hong Kong Med J. 2009; 15:110-7.Search in Google Scholar

16. Gharib NM, Shah P. Anthropometry and body composition of school children in Bahrain. Ann Saudi Med. 2009; 29:258-69.10.4103/0256-4947.55309Open DOISearch in Google Scholar

17. Chakrabarty AS, Pillai RV, Anand BK, Singh B. Effect of cyproheptadine on the electrical activity of the hypothalamic feeding centres. Brain Res. 1967; 6: 561-9.10.1016/0006-8993(67)90066-2Open DOISearch in Google Scholar

18. Montgomery AM, Fletcher PJ, Burton MJ. Behavioural and pharmacological investigations of 5-HT hypophagia and hyperdipsia. Pharmacol Biochem Behav. 1986; 25:23-8.10.1016/0091-3057(86)90224-8Search in Google Scholar

19. Sakata T, Ookuma K, Fukagawa K, Fujimoto K, Yoshimatsu H, Shiraishi T, et al. Blockade of the histamine H1-receptor in the rat ventromedial hypothalamus and feeding elicitation. Brain Res. 1988; 441:403-7.10.1016/0006-8993(88)91423-0Search in Google Scholar

20. Baxter MG, Miller AA, Soroko FE. The effect of cyproheptadine on food consumption in the fasted rat. Br J Pharmacol. 1970; 39:229P-30P.Search in Google Scholar

21. Ghosh MN, Parvathy S. The effect of cyproheptadine on water and food intake and on body weight in the fasted adult and weanling rats. Br J Pharmacol. 1973; 48:328P-9P.Search in Google Scholar

22. Rahman KM. Appetite stimulation and weight gain with cyproheptadine (periactin) in tuberculosis patients (double-blind clinical study). Med J Malaysia. 1975; 29:270-4.Search in Google Scholar

23. Silverstone T, Schuyler D. The effect of cyproheptadine on hunger, calorie intake and body weight in man. Psychopharmacologia. 1975; 40:335-40.10.1007/BF004214721096217Open DOISearch in Google Scholar

24. Toth K, Szonyi A. The appetite stimulating and weight gain promoting effect of peritol (cyproheptadine) examined on a great number of outpatients. Ther Hung. 1976; 24:24-32.Search in Google Scholar

25. Ambrosini GL, de Klerk NH, O’Sullivan TA, Beilin LJ, Oddy WH. The reliability of a food frequency questionnaire for use among adolescents. Eur J Clin Nutr. 2009; 63:1251-9.10.1038/ejcn.2009.4419550427Search in Google Scholar

26. Collett-Solberg PF, Misra M. The role of recombinant human insulin-like growth factor-I in treating children with short stature. J Clin Endocrinol Metab. 2008; 93: 10-8.10.1210/jc.2007-153418165284Search in Google Scholar

27. Lemaire P, Brauner N, Hammer P, Trivin C, Souberbielle JC, Brauner R. Improved screening for growth hormone deficiency using logical analysis data. Med Sci Monit. 2009; 15:MT5-10.Search in Google Scholar

28. Spiliotis BE, Alexandrides TK, Karystianos C, Vassilakos P, Zadik Z, Nikolakopoulou NM, et al. The insulin-like growth factor-I (IGF-I) generation test as an indicator of growth hormone status. Hormones (Athens). 2009; 8:117-28.10.14310/horm.2002.122819570739Search in Google Scholar

eISSN:
1875-855X
Language:
English
Publication timeframe:
6 times per year
Journal Subjects:
Medicine, Assistive Professions, Nursing, Basic Medical Science, other, Clinical Medicine