Increased cardiac microvascular permeability and activation of cardiac endothelial nitric oxide synthase in high tidal volume ventilation-induced lung injury

1. Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev. 1999; 13:2905-27.10.1101/gad.13.22.2905Search in Google Scholar

2. Toker A, Newton AC. Cellular signaling: pivoting around PDK-1. Cell. 2000; 103:185-8.10.1016/S0092-8674(00)00110-0Search in Google Scholar

3. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 1999; 399:601-5.10.1038/2122410376603Search in Google Scholar

4. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 1999; 399:597-601.10.1038/21218363791710376602Search in Google Scholar

5. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med. 1993; 329:2002-12. 10.1056/NEJM1993123032927067504210Search in Google Scholar

6. Broccard AF, Hotchkiss JR, Vannay C, Markert M, Sauty A, Feihl F, et al. Protective effects of hypercapnic acidosis on ventilator-induced lung injury. Am J Respir Crit Care. Med 2001; 164:802-6.Search in Google Scholar

7. Li LF, Liao SK, Lee CH, Huang CC, Quinn DA. Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment. Crit Care. 2007: 11:R89.10.1186/cc6101220648417714594Open DOISearch in Google Scholar

8. Choi WI, Quinn DA, Park KM, Moufarrej RK, Jafari B, Syrkina O, et al. Systemic microvascular leak in an in vivo rat model of ventilator-induced lung injury. Am J Respir Crit Care Med. 2003; 167:1627-32.10.1164/rccm.200210-1216OC12663326Search in Google Scholar

9. Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS. Injurious ventilatory strategies increase cytokines and c-fos mRNA expression in an isolated rat lung model. J Clin Invest. 1997; 99:944-52.10.1172/JCI1192595079029062352Search in Google Scholar

10. Umeno E, Nadel JA, McDonald DM. Neurogenic inflammation of the rat trachea: fate of neutrophils that adhere to venules. J Appl Phyiol. 1990; 69:2131-6.10.1152/jappl.1990.69.6.21311963889Search in Google Scholar

11. McDonald DM. Endothelial gaps and permeability of venules in rat tracheas exposed to inflammatory stimuli. Am J Physiol. 1994; 266(1 Pt 1):L61-83.10.1152/ajplung.1994.266.1.L617508201Search in Google Scholar

12. Uhlig S. Ventilation-induced lung injury and mechanotransduction: stretching it too far? Am J Physiol Lung Cell Mol Physiol. 2002; 282:L892-6.10.1152/ajplung.00124.2001Search in Google Scholar

13. Petroff MG, Kim SH, Pepe S, Dessy C, Marban E, Balligand JL, et al. Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes. Nat Cell Biol. 2001; 3: 867-73.10.1038/ncb1001-867Open DOISearch in Google Scholar

14. Thelen M, Didichenko SA. G-protein coupled receptormediated activation of PI 3-kinase in neutrophils. Ann N Y Acad Sci. 1997; 832:368-82.10.1111/j.1749-6632.1997.tb46265.xSearch in Google Scholar

15. Toker A. Protein kinases as mediators of phosphoinositide 3-kinase signaling. Mol Pharmacol. 2000;57:652-8.10.1124/mol.57.4.652Search in Google Scholar

16. Stein RC, Waterfield MD. PI3-kinase inhibition: a target for drug development? Mol Med Today. 2000; 6: 347-57.10.1016/S1357-4310(00)01770-6Open DOISearch in Google Scholar

17. Rikitake Y, Liao JK. Rho GTPases, statins, and nitric oxide. Circ Res. 2005; 97:1232-5.10.1161/01.RES.0000196564.18314.23263358916339495Search in Google Scholar

18. Mehta D, Malik AB. Signaling mechanisms regulating endothelial permeability. Physiol Rev. 2006; 86:279-367.10.1152/physrev.00012.200516371600Open DOISearch in Google Scholar

19. van Nieuw Amerongen GP, Beckers CM, Achekar ID, Zeeman S, Musters RJ, van Hinsbergh VW. Involvement of Rho kinase in endothelial barrier maintenance. Arterioscler Thromb Vasc Biol. 2007; 27: 2332-9.10.1161/ATVBAHA.107.15232217761936Open DOISearch in Google Scholar