Analysis of Protein Adducts as Biomarkers of Short-Term Exposure to Ethylene Oxide and Results of Follow-Up Biomonitoring

World Health Organization (WHO). Ethylene oxide. Environmental Health Criteria 55. Geneva: World Health Organization; 1985.Search in Google Scholar

Deutsche Forschungsgemeinschaft (DFG). Ethylene oxide. In: Henschler D, editor. Occupational toxicants. Critical data evaluation for MAK values and classification of carcinogens. Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area. Vol. 5. Weinheim: VCH Verlagsgesellschaft; 1993. p. 182-92.Search in Google Scholar

International Agency for Research on Cancer (IARC). Monographs on the evaluation of carcinogenic risks to humans. 1,3-Butadiene, Ethylene Oxide and Vinyl Halides (Vinyl Fluoride, Vinyl Chloride and Vinyl Bromide). Vol. 97. Lyon: IARC; 2008.Search in Google Scholar

Angerer J, Bader M, Krämer A. Ambient and biochemical effect monitoring of workers exposed to ethylene oxide. Int Arch Occup Environ Health 1998;71:14-8.10.1007/s004200050244Search in Google Scholar

Rosenberger W, Graubner G, Wrbitzky R, Bader M. [Untersuchungen zur Freisetzung von Ethylenoxid aus gassterilisierten neurochirurgischen Implantaten, in German]. Presentation on the occasion of the 49. Jahrestagung der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin (DGAUM). In: Kraus Th, Gube M, editors. 49. Jahrestagung der Deutschen Gesellschaft für Arbeitsmedizin und Umweltmedizin (DGAUM), 2009. Documentation on CD-ROM.Search in Google Scholar

Gemeinsames Ministerialblatt (GMBl). [Bek. v. 2.8.10, Bekanntmachung von Empfehlungen für Biomonitoring bei Tätigkeiten mit krebserzeugenden Gefahrstoffen, in German]. GMBI 2010;62:1257-60.Search in Google Scholar

Gemeinsames Ministerialblatt (GMBI). [TRGS 513 (Technische Regel für Gefahrstoffe) Tätigkeiten an Sterilisatoren mit Ethylenoxid und Formaldehyd, in German]. GMBI 2011;49-51:993-1018.Search in Google Scholar

Norpoth K, Bolt HM. Ethylene oxide [BAT Value Documentation, 1995]. The MAK-Collection for Occupational Health and Safety [displayed 17 May 2012]. Available at http://onlinelibrary.wiley.com/doi/10.1002/3527600418.bb7521e0002/pdfSearch in Google Scholar

Bolt H. Ethylene oxide, Addendum [BAT Value Documentation, 2010]. The MAK-Collection for Occupational Health and Safety [displayed 17 May 2012]. Available at http://onlinelibrary.wiley.com/doi/10.1002/3527600418.bb7521e0005/pdfSearch in Google Scholar

Törnqvist M, Mowrer J, Jensen S, Ehrenberg L. Monitoring of environmental cancer initiators through hemoglobin adducts by a modified Edman degradation method. Anal Biochem 1986;154:255-66.10.1016/0003-2697(86)90524-5Search in Google Scholar

Lewalter J. N-alkylvaline levels in globin as a new type of biomarker in risk assessment of alkylating agents. Int Arch Occup Environ Health 1996;68:519-30.10.1007/BF00377881Search in Google Scholar

Törnqvist M, Fred C, Haglund J, Helleberg B, Paulsson B, Rydberg P. Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications. J Chromatogr B Analyt Technol Biomed Life Sci 2002;778:279-308.10.1016/S1570-0232(02)00172-1Search in Google Scholar

Deutsche Forschungsgemeinschaft (DFG). List of MAK and BAT values 2011. Maximum Concentrations and Biological Tolerance Values at the Workplace. Report 47. Weinheim: Wiley-VCH; 2011.10.1002/9783527666034Search in Google Scholar

Bailey E, Brooks AGF, Dollery CT, Farmer PB, Passingham BJ, Sleightholm M, Yates DW. Hydroxyethylvaline adduct formation in haemoglobin as a biological monitor of cigarette smoke intake. Arch Toxicol 1988;62:247-53.10.1007/BF00332482Search in Google Scholar

Persson KA, Berg S, Törnqvist M, Scalia-Tomba GP, Ehrenberg L. Note on ethene and other low-molecular weight hydrocarbons in environmental tobacco smoke. Acta Chem Scand B 1988;42:690-6.10.3891/acta.chem.scand.42b-0690Search in Google Scholar

Bader M, Lewalter J, Angerer J. Analysis of N-alkylated amino acids in human hemoglobin: evidence for elevated N-methylvaline levels in smokers. Int Arch Occup Environ Health 1995;67:237-42.10.1007/BF00409405Search in Google Scholar

van Sittert NJ, Angerer J, Bader M, Blaskewicz M, Ellrich D, Krämer A, Lewalter J. N-2-cyanoethylvaline, N-2-hydroxyethylvaline, N-methylvaline (as evidence of exposure to acrylonitrile, ethylene oxide and well as methylating agents). In: Angerer J, Schaller KH, editors. Analyses of hazardous substances in biological materials. Vol. 5. Weinheim: Wiley-VCH; 1997. p. 181-210.10.1002/3527600418.bi2176851e0005Search in Google Scholar

Osterman-Golkar S, Ehrenberg L, Segerbäck D, Hällström I. Evaluation of genetic risks of alkylating agents. II. Haemoglobin as a dose monitor. Mutat Res 1976;34:1-10.10.1016/0027-5107(76)90256-6Search in Google Scholar

Osterman-Golkar S. Dosimetry of ethylene oxide. IARC Sci Publ 1988;89:249-57.Search in Google Scholar

Granath F, Ehrenberg L, Törnqvist M. Degree of alkylation of macromolecules in vivo from variable exposure. Mutat Res 1992;284:297-306.10.1016/0027-5107(92)90014-SSearch in Google Scholar

Fennell TR, Sumner SCJ, Walker VE. A model for the formation and removal of hemoglobin adducts. Cancer Epidemiol Biomarkers Prev 1992;1:213-9.Search in Google Scholar

Schettgen T, Broding HC, Angerer J, Drexler H. Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine. Toxicol Letters 2002;34:65-70.10.1016/S0378-4274(02)00164-9Search in Google Scholar

Bader M, Hecker H, Wrbitzky R. Querschnittstudie zur ernährungs- und tabakrauchbedingten Belastung der Allgemeinbevölkerung mit Acrylamid [Cross-sectional study on dietary and smoking related exposure to acrylamide, in German]. Dtsch Ärztebl 2005;39:B2231-4.Search in Google Scholar

Müller M, Heinrich-Ramm R, Hoppe HW. Cotinine. In: Angerer J, Schaller KH editors. Analyses of hazardous substances in biological materials. Vol. 8. Weinheim: Wiley-VCH; 2003. p. 53-65.Search in Google Scholar

Tsikas D, Wolf A, Mitschke A, Gutzki FM, Will W, Bader M. GC-MS determination of creatinine in human biological fluids as pentafluorobenzyl derivative in clinical studies and biomonitoring: Interlaboratory comparison in urine with Jaffé, HPLC and enzymatic assays. J Chromatogr B Analyt Technol Biomed Life Sci 2010;878:2582-92.10.1016/j.jchromb.2010.04.025Search in Google Scholar

BASF Chemical Emergency Medical Guidelines. Ethylene oxide [displayed 17 May 2012]. Available at http://www.basf.com/group/corporate/en/sustainability/employees/occupational-medicine/responsiblecareSearch in Google Scholar

UBA (Umweltbundesamt, German Federal Environment Agency) Umwelt-Survey 1998, Band III: Human-Biomonitoring. Stoffgehalte in Blut und Urin der Bevölkerung in Deutschland. WaBoLu-Hefte 2002;1:214.Search in Google Scholar

Törnqvist M, Gustafsson B, Kautiainen A, Harms-Ringdahl M, Granath F, Ehrenberg L. Unsaturated lipids and intestinal bacteria as sources of endogenous production of ethene and ethylene oxide. Carcinogenesis 1989;10:39-41.10.1093/carcin/10.1.39Search in Google Scholar

Walker VE, MacNeela JP, Swenberg JA, Turner MJ, Fennell TR. Molecular dosimetry of ethylene oxide: Formation and Persistence of N-(2-hydroxyethyl)valine in hemoglobin following repeated exposures of rats and mice. Cancer Res 1992;52:4320-7.Search in Google Scholar

Granath F, Westerholm R, Peterson A, Törnqvist M, Ehrenberg L. Uptake and metabolism of ethene studied in a smoke-stop experiment. Mutat Res 1994;313:285-91.10.1016/0165-1161(94)90058-2Search in Google Scholar

Bader M, Wrbitzky R. Follow-up biomonitoring after accidental exposure to acrylonitrile - Implications for protein adducts as a dose monitor for short-term exposures. Toxicol Lett 2006;162:125-31.10.1016/j.toxlet.2005.09.03416280213Search in Google Scholar

Filser JG, Denk B, Törnqvist M, Kessler W, Ehrenberg L. Pharmacokinetics of ethylene oxide in man; body burden with ethylene oxide and hydroxyethylation of hemoglobin due to endogenous and environmental ethylene. Arch Toxicol 1992;66:157-63.10.1007/BF019740081303633Search in Google Scholar