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Cytotoxic and Genotoxic Effects of the Quercetin/Lanthanum Complex on Human Cervical Carcinoma Cells In Vitro


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Wang B, Yang Z-Y, Wang Q, Cai T, Crewdson P. Synthesis, characterization, cytotoxic activities and DNA binding properties of the La(III) complex with naringenin Schiff-base. Bioorg Med Chem 2006;14:1880-8.10.1016/j.bmc.2005.10.031Search in Google Scholar

Day Y, Li J, Li J, Yu L, Dai G, Hu A, Yuan L, Wen Z. Effects of rare earth compounds on growth and apoptosis of leukemic cell lines. In vitro Cell Dev Biol Anim 2002;38:373-5.10.1290/1071-2690(2002)038<0373:EORECO>2.0.CO;2Search in Google Scholar

Zhang Z, Wang J, Li J, Xu S. Telomerase-mediated apoptosis of chicken lymphoblastoid tumor cell line by lanthanum chloride. Biol Trace Elem Res 2011. DOI: 10.1007/s12011-011-9027-810.1007/s12011-011-9027-8Search in Google Scholar

Kovacic P, Popp WJ, Ames JR, Ryan MD. Anti-cancer action of metal complexes:electron transfer and oxidative stress? Anticancer Drug Des 1988;3:205-16.Search in Google Scholar

Kostova I, Momekov G, Zaharieva M, Karaivanova M. Cytotoxic activity of new lanthanum (III) complexes of biscoumarins. Eur J Med Chem 2005;40:542-51.10.1016/j.ejmech.2004.12.007Search in Google Scholar

Brabec V, Nováková O. DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity. Drug Resist Updat 2006;9;111-22.10.1016/j.drup.2006.05.002Search in Google Scholar

Kleemann R, Verschuren L, Morrison M, Zadelaar S, van Erk MJ, Wielinga PY, Kooistra T. Anti-inflammatory, anti-proliferative and anti-atheroschlerotic effects of quercetin in human in vitro and in vivo models. Atheroschlerosis 2011;218:44-52.10.1016/j.atherosclerosis.2011.04.023Search in Google Scholar

Durgo K, Vuković L, Rusak G, Osmak M, Franekić Čolić J. Effect of flavonoids on glutathione level, lipid peroxidation and cytochrome P450 CYP1A1 expression in human laryngeal carcinoma cell lines. Food Technol Biotechnol 2007;45:69-79.Search in Google Scholar

Pietta PG. Flavonoids as antioxidants. J Nat Prod 2000;63:1035-42.10.1021/np9904509Search in Google Scholar

Boots AW, Balik JM, Bast A, Haenen GRMM. The reversibility of the glutathionyl-quercetin adduct spreads oxidised quercetin-induced toxicity. Biochem Biophys Res Commun 2005;338:923-9.10.1016/j.bbrc.2005.10.031Search in Google Scholar

van der Woude H, Gliszczyńska-Świgło A, Struijs K, Smeets A, Alink GM, Rietjens IMCM. Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans. Cancer Lett 2003;200:41-7.10.1016/S0304-3835(03)00412-9Search in Google Scholar

Marinić M, Piantanida I, Rusak G, Žinić M. Interactions of quercetin and its lanthane complex with double stranded DNA/RNA and single stranded RNA. Spectrophotometric sensing of poly G. J Inorg Biochem 2006;100:288-98.10.1016/j.jinorgbio.2005.11.013Search in Google Scholar

Čemažar M, Marolt D, Lavrič M, Serša G. Comparison of colorimetric MTT and clonogenic assays for irradiation and cisplatin treatment on murine fibrosarcoma SA-1 cells. Radiol Oncol 1999;33:303-8.Search in Google Scholar

Matsuo M, Sasaki N, Saga K, Kaneko T. Cytotoxicty of flavonoids toward cultured normal human cells. Biol Pharm Bull 2005;28:253-9.10.1248/bpb.28.253Search in Google Scholar

Cereser C, Boget S, Parvaz P, Revol A. Thiram-induced cytotoxicity is accompanied by a rapid and drastic oxidation of reduced glutathione with consecutive lipid peroxidation and cell death. Toxicology 2001;163:153-62.10.1016/S0300-483X(01)00401-2Search in Google Scholar

McCarthy S, Somayajulu M, Sikorska M, Borowy-Borowski H, Pandey S. Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water soluble Coenzyme Q-10. Toxicol Appl Pharmacol 2004;201:21-31.10.1016/j.taap.2004.04.019Search in Google Scholar

Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biochem 1976;72:248-54.10.1016/0003-2697(76)90527-3Search in Google Scholar

Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988;175:184-91.10.1016/0014-4827(88)90265-0Search in Google Scholar

Rusak G, Piantanida I, Mašić L, Kapuralin K, Durgo K, Kopjar N. Spectrophotometric analysis of flavonoid-DNA interactions and DNA damaging/protecting and cytotoxic potential of flavonoids in human peripheral blood lymphocytes. Chem-Biol Interact 2010;188:181-9.10.1016/j.cbi.2010.07.008Search in Google Scholar

Durgo K, Kostić S, Gradiški K, Komes D, Osmak M, Franekić J. Genotoxic effects of green tea extract on human laryngeal carcinoma cells in vitro. Arh Hig Rada Toksikol 2011:62:139-46.10.2478/10004-1254-62-2011-2105Search in Google Scholar

Plochmann K, Korte G, Koutsilieri E, Richling E, Riederer P, Rethwilm A, Schreier P, Scheller P. Structure-activity relationships of flavonoid-induced cytotoxicity on human leukemia cells. Arch Biochem Biophys 2007;460:1-9.10.1016/j.abb.2007.02.003Search in Google Scholar

Durgo K, Vuković L, Rusak G, Osmak M, Franekić Čolić J. Cytotoxic and apoptotic effect of structurally similar flavonoids on parental and drug-resistant cells of a human cervical carcinoma. Food Technol Biotechnol 2009;47:323-30.Search in Google Scholar

Sergediené E, Jönsson K, Szymusiak H, Tyrakowska B, Rietjens IMCM, Čėnas N. Prooxidant toxicity of polyphenolic antioxidants to HL-60 cells: description of quantitative structure-activity relationships. FEBS Lett 1999;462:392-6.10.1016/S0014-5793(99)01561-6Search in Google Scholar

Walle T. Serial Review: Flavonoids and isoflavones (phytoestrogenes): absorption, metabolism and bioactivity: absorption and metabolism of flavonoids. Free Radic Biol Med 2004;36:829-37.10.1016/j.freeradbiomed.2004.01.00215019968Search in Google Scholar

Gutzeit HO, Henker Y, Kind B, Franz A. Specific interactions of quercetin and other flavonoids with target proteins are revealed by elicited fluorescence. Biochem Biophys Res Comm 2004;318:490-5.10.1016/j.bbrc.2004.04.07815120627Search in Google Scholar

ISSN:
0004-1254
Languages:
English, Slovenian
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Basic Medical Science, other