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Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium


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Nordberg NF. Historical perspectives on cadmium toxicology. Toxicol Appl Pharmacol 2009;238:192-200.10.1016/j.taap.2009.03.015Search in Google Scholar

Friberg L. Proteinuria and kidney injury among workmen exposed to cadmium and nickel dust. J Ind Hyg Toxicol 1948;30:32-6.Search in Google Scholar

Tcuchiya K. Causation of ouch-ouch disease (Itai-Itai Byõ) an introductory review. II. Epidemiology and evaluation. Keio J Med 1969;18:181-94.10.2302/kjm.18.181Search in Google Scholar

Margoshes M, Vallee BL. A cadmium protein from equine kidney cortex. J Am Chem Soc 1957;79:4813-4.10.1021/ja01574a064Search in Google Scholar

Kagi JH, Vallee BL. Metallothionein: a cadmium- and zinccontaining protein from equine renal cortex. J Biol Chem 1960;235:3460-5.10.1016/S0021-9258(18)64490-4Search in Google Scholar

Sabolić I, Breljak D, Škarica M, Herak-Kramberger CM. Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs. Biometals 2010;23(5 Special Issue):897-926.10.1007/s10534-010-9351-z20549307Search in Google Scholar

Memiši N, Žujović M, Bogdanović V, Tomić Z, Petrović MP. The influence of presence of cadmium and arsenic in feedmeal on production and reproduction traits of goats. Biotechnol Anim Husbandry 2008;24:39-47.10.2298/BAH0804039MSearch in Google Scholar

Lane TW, Saito MA, George GN, Pickering IJ, Prince RC, Morell FMM. Biochemistry: A cadmium enzyme from a marine diatom. Nature 2005;435:42.10.1038/435042a15875011Search in Google Scholar

Derfus AM, Chan WCW, Bhatia SN. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 2004;4:11-8.10.1021/nl0347334558868828890669Search in Google Scholar

Kirchner C, Liedl T, Kudera S, Pellegrino T, Muñoz Javier A, Gaub HE, Stölzle S, Fertig N, Parak WJ. Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett 2005;5:331-8.10.1021/nl047996m15794621Search in Google Scholar

Green M, Howman E. Semiconductor quantum dots and free radical induced DNA nicking. Chem Commun 2005;1: 121-3.10.1039/b413175d15614393Search in Google Scholar

Smith AM, Duan h, Mohs AM, Nie S. Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv Drug Delivery Rev 2008;60:1226-40.10.1016/j.addr.2008.03.015Search in Google Scholar

New insights into the mechanisms of cadmium toxicity - Advances in cadmium research, Special issue. Toxicol Appl Pharmacol 2009;238 (3): 191-326.Search in Google Scholar

Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for cadmium. Atlanta (USA): ATSDR; 2008.Search in Google Scholar

Lewis GP, Coughlin LL, Jusko WJ, Hartz S. Contribution of cigarette smoking to cadmium accumulation in man. Lancet 1972;299:291-2.10.1016/S0140-6736(72)90294-2Search in Google Scholar

Nawrot TS, Staessen JA, Roels HA, Munters E, Cuypers A, Richart T, Ruttens A, Smeets K, Clijsters h, Vangronsveld J. Cadmium exposure in the population: from health risks to strategies of prevention. Biometals 2010;23:769-82.10.1007/s10534-010-9343-z20517707Search in Google Scholar

Agency for Toxic Substances and Disease Registry (ATSDR). CERCLA Priority list of hazardous substances that will be the subject of toxicological profiles and support document. Atlanta (USA): ATSDR, U. S. Department of Health and Human Services; 2007.Search in Google Scholar

Bhattacharyya MH. Cadmium osteotoxicity in experimental animals: Mechanisms and relationship to human exposures. Toxicol Appl Pharmacol 2009;238:258-65.10.1016/j.taap.2009.05.015282616519463839Search in Google Scholar

Everett CJ, Frithsen IL. Association of urinary cadmium and myocardial infarction. Environ Res 2008;106:284-6.10.1016/j.envres.2007.10.00918053980Search in Google Scholar

Edwards JR, Prozialeck WC. Cadmium, diabetes and chronic kidney disease. Toxicol Appl Pharmacol 2009;238:289-93.10.1016/j.taap.2009.03.007270971019327375Search in Google Scholar

Darbre PD. Metalloestrogens: An emerging class of inorganic xenoestrogens with potential to add to the estrogenic burden of the human breast. J Appl Toxicol 2006;26:191-7.10.1002/jat.113516489580Search in Google Scholar

McElroy JA, Shafer MM, Trentham-Dietz A, Hampton JM, Newcomb PA. Cadmium exposure and breast cancer risk. J Natl Cancer Inst 2006;98:869-73.10.1093/jnci/djj23316788160Search in Google Scholar

Il'yasova D, Schwartz GG. Cadmium and renal cancer. Toxicol Appl Pharmacol 2005;207:179-86.10.1016/j.taap.2004.12.00516102569Search in Google Scholar

International Agency for Research on Cancer (IARC). Cadmium and cadmium compounds, In: IARC Monographs on the evaluation of carcinogenic risks to humans. Vol. 58. Beryllium, cadmium, mercury, and exposures in the glass manufacturing industry. Lyon: IARC; 1993. p. 119-237.Search in Google Scholar

NTP Report on Carcinogens Background Document for Cadmium, March 1999. NIEHS Contract No. NO1-ES-25346 [displayed 9 January 2011]. Available at http://ntp.niehs.nih.gov/files/Cadmium.pdfSearch in Google Scholar

Nawrot TS, Van Hecke E, Thijs L, Richart T, Kuznetsova T, Jin Y, Vangronsveld J, Roels HA, Staessen JA. Cadmium-related mortality and long-term secular trends in the cadmium body burden of an environmentally exposed population. Environ Health Perspect 2008;116:1620-8.10.1289/ehp.11667259975419079711Search in Google Scholar

Jin YH, Clark AB, Slebos RJ, Al-Refai h, Taylor JA, Kunkel TA, Resnick MA, Gordenin DA. Cadmium is a mutagen that acts by inhibiting mismatch repair. Nat Genet 2003;34: 326-9.10.1038/ng1172Search in Google Scholar

Pan J, Plant JA, Voulvoulis N, Oates CJ, Ihlenfeld C. Cadmium levels in Europe: implications for human health. Environ Geochem Health 2010;32:1-12.10.1007/s10653-009-9273-2Search in Google Scholar

Joseph P. Mechanisms of cadmium carcinogenesis. Toxicol Appl Pharmacol 2009;238:272-9.10.1016/j.taap.2009.01.011Search in Google Scholar

Moulis J-M. Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals. Biometals 2010;23:877-96.10.1007/s10534-010-9336-ySearch in Google Scholar

Matović V, Plamenac-Bulat Z, Djukić-Ćosić D, Soldatović D. Antagonism between cadmium and magnesium: a possible role of magnesium in therapy of cadmium intoxication. Magnesium Res 2010;23:19-26.10.1684/mrh.2010.0196Search in Google Scholar

Lazarus M. Međudjelovanje kadmija i selenija u sisavaca. Arh Hig Rada Toksikol 2010;61:357-69.10.2478/10004-1254-61-2010-2021Search in Google Scholar

Müller L. Consequences of cadmium toxicity in rat hepatocytes: Mitochondrial dysfunction and lipid peroxidation. Toxicology 1986;40:285-95.10.1016/0300-483X(86)90061-2Search in Google Scholar

Hart BA, Lee CH, Shukla GS, Shukla A, Osier A, Eneman JD, Chiu JF. Characterization of cadmium-induced apoptosis in rat lung epithelial cells: evidence for the participation of oxidant stress. Toxicology 1999;133:43-5810.1016/S0300-483X(99)00013-XSearch in Google Scholar

Liu F, Jan KY. DNA damage in arsenite-and cadmium-treated bovine aortic endothelial cells. Free Radic Biol Med 2000;28:55-63.10.1016/S0891-5849(99)00196-3Search in Google Scholar

Manca D, Richard AC, Tra HV, Chevalier G. Relation between lipid peroxidation and inflammation in the pulmonary toxicity of cadmium. Arch Toxicol 1994;68: 364-9.10.1007/s0020400500838092928Search in Google Scholar

Amara S, Abdelmelek H, Garrel C, Guiraud P, Douki T, Ravanat J-L, Favier A, Sakly M, Ben Rhouma K. Preventive effect of zinc against cadmium-induced oxidative stress in the rat testis. J Reprod Dev 2008;54:129-34.10.1262/jrd.18110Search in Google Scholar

Djukić-Ćosić D, Ćurčić-Jovanović M, Plamenac-Bulat Z, Ninković M, Maličević Z, Matović V. Relation between lipid peroxidation and iron concentration in mouse liver after acute and subacute cadmium intoxication. J Trace Elem Med Biol 2008;22:66-72.10.1016/j.jtemb.2007.09.024Search in Google Scholar

Valko M, Morris H, Cronin MTD. Metals, toxicity and oxidative stress. Curr Med Chem 2005;12:1161-208.10.2174/0929867053764635Search in Google Scholar

Liu J, Qu W, Kadiiska MB. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol 2009;238:209-14.10.1016/j.taap.2009.01.029Search in Google Scholar

Djukić-Ćosić D, Ninković M, Maličević Ž, Matović V, Soldatović D. Effect of magnesium pretreatment on reduced gluthatione levels in tissues of mice exposed to acute and subacute cadmium intoxication: a time course study. Magnes Res 2007;20:177-86.Search in Google Scholar

Casalino E, Sblano C, Landriscina C. Enzyme activity alteration by cadmium administration to rats: the possibility of iron involvement in lipid peroxidation. Arch Biochem Biophys 1997;346:171-9.10.1006/abbi.1997.0197Search in Google Scholar

Yamano T, DeCicco LA, Rikans LE. Attenuation of cadmium-induced liver injury in senescent male fischer 344 rats: role of Kupffer cells and inflammatory cytokines. Toxicol Appl Pharmacol 2000;162:68-75.10.1006/taap.1999.8833Search in Google Scholar

Belyaeva EA, Dymkowska D, Wieckowski MR, Wojtczak L. Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells. Toxicol Appl Pharmacol 2008;231:34-42.10.1016/j.taap.2008.03.017Search in Google Scholar

Shaikh ZA, Vu TT, Zaman K. Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by antioxidants. Toxicol Appl Pharmacol 1999;154:256-63.10.1006/taap.1998.8586Search in Google Scholar

Ramirez DC, Gimenez MS. Induction of redox changes, inducible nitric oxide synthase and cyclooxygenase-2 by chronic cadmium exposure in mouse peritoneal macrophages. Toxicol Lett 2003;145:121-32.10.1016/S0378-4274(03)00237-6Search in Google Scholar

Waisberg M, Joseph P, Hale B, Beyersmann D. Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 2003;192:95-117.10.1016/S0300-483X(03)00305-6Search in Google Scholar

Thijssen S, Cuypers A, Maringwa J, Smeets K, Horemans N, Lambrichts I, Van Kerkhove E. Low cadmium exposure triggers a biphasic oxidative stress response in mice kidneys. Toxicology 2007;236:29-41.10.1016/j.tox.2007.03.022Search in Google Scholar

Qu W, Diwan BA, Reece JM, Bortner CD, Pi J, Liu J, Waalkes MP. Cadmium-induced malignant transformation in rat liver cells: Role of aberrant oncogene expression and minimal role of oxidative stress. Int J Cancer 2005;114:346-55.10.1002/ijc.20736Search in Google Scholar

Wuehler SE, Peerson JM, Brown KH. Use of national food balance data to estimate the adequacy of zinc in national food supplies: Methodology and regional estimates. Public Health Nutr 2005;8:812-9.10.1079/PHN2005724Search in Google Scholar

Task Group on Metal Interactions. Factors influencing metabolism and toxicity of metals: a consensus report. Environ Health Perspect 1978;25:3-41.Search in Google Scholar

Plamenac Z, Matović V, Vujanović D, Soldatović D. Zinc content in rabbits submitted to prolonged cadmium intoxication. In: Kovatsis AV, Tsoukali-Papadopoulou h, editors. Aspects on Forensis Toxicology. Greece: Thessaloniki-Tecnika Studio; 1995. p. 31-5.Search in Google Scholar

Brzóska MM, Moniuszko-Jakoniuk J. Interactions between cadmium and zinc in the organism. Food Chem Toxicol 2001;39:967-80.10.1016/S0278-6915(01)00048-5Search in Google Scholar

Ishitobi h, Watanabe C. Effects of low-dose perinatal cadmium exposure on tissue zinc and copper concentrations in neonatal mice and on the reproductive development of female offspring. Toxicol Lett 2005;159:38-46.10.1016/j.toxlet.2005.04.006Search in Google Scholar

Martelli A, Rousselet E, Dycke C, Bouron A, Moulis JM. Cadmium toxicity in animal cells by interference with essential metals. Biochimie 2006;88:1807-14.10.1016/j.biochi.2006.05.013Search in Google Scholar

Osman K, Akesson A, Berglund M, Bremme K, Schütz A, Ask K, Vahter M. Toxic and essential elements in placentas of Swedish women. Clin Biochem 2000;33:131-8.10.1016/S0009-9120(00)00052-7Search in Google Scholar

Sorell TL, Graziano JH. Effect of oral cadmium exposure during pregnancy on maternal and fetal zinc metabolism in the rat. Toxicol Appl Pharmacol 1990;102:537-45.10.1016/0041-008X(90)90048-YSearch in Google Scholar

Plamenac Bulat Z. Interakcije kadmijuma i bioelemenata cinka, bakra i magnezijuma kod ljudi i kunića izloženih kadmijumu [Interactions of cadmium and bioelements zinc, copper and magnesium in humans and rabbits exposed to cadmium, in Serbian]. [PhD thesis]. Belgrade: Faculty of Pharmacy, University of Belgrade; 2009.Search in Google Scholar

Soldatović D, Matović V, Vujanović D, Stojanović Z. Contribution to interaction between magnesium and toxic metals: the effect of prolonged cadmium intoxication on magnesium metabolism in rabbits. Magnes Res 1998;11: 283-8.Search in Google Scholar

Smetana RH, Glogar DH, Gemeiner M. Role of cadmium and magnesium in pathogenesis of idiopathic dilated cardiomyopathy. Am J Cardiol 1986;58:364-6.10.1016/0002-9149(86)90082-2Search in Google Scholar

Ezaki T, Tsukahara T, Moriguchi J, Furuki K, Fukui Y, Ukai H, Okamoto S, Sakurai H, Honda S, Ikeda M. Analysis for threshold levels of cadmium in urine that induce tubular dysfunction among women in non-polluted areas in Japan. Int Arch Occup Environ Health 2003;76:197-204.10.1007/s00420-002-0390-912690494Search in Google Scholar

Plamenac Bulat Z, Đukić-Ćosić D, Đokić M, Bulat P, Matović V. Blood and urine cadmium and bioelements profile in nickel-cadmium battery workers in Serbia. Toxicol Ind Health 2009;25:129-35.10.1177/074823370910448819458135Search in Google Scholar

World Health Organization (WHO). Cadmium. Environmental Health Criteria No. 134. Geneva: WHO; 1992.Search in Google Scholar

Pařizek J. The destructive effect of cadmium ion on testicular tissue and its prevention by zinc. J Endocrinol 1957;15: 56-63.10.1677/joe.0.015005613439083Search in Google Scholar

Barbier O, Jacquillet G, Taue M, Poujeol P, Cougnon M. Acute study of interaction among cadmium, calcium, and zinc transport along the rat nephron in vivo. Am J Physiol Renal Physiol 2004;287:F1067-75.10.1152/ajprenal.00120.200415280159Search in Google Scholar

Jacquillet G, Barbier O, Cougnon M, Tauc M, Namorado MC, Martin D, Reyes JL, Poujeol P. Zinc protects renal function during cadmium intoxication in the rat. Am J Physiol Renal Physiol 2006;290:F127-37.10.1152/ajprenal.00366.200415942048Search in Google Scholar

Brzóska MM, Rogalska J, Galazyn-Sidorczuk M, Jurczuk M, Roszczenko A, Kulikowska-Karpińska E, Moniuszko-Jakoniuk J. Effect of zinc supplementation on bone metabolism in male rats chronically exposed to cadmium. Toxicology 2007;237:89-103.10.1016/j.tox.2007.05.00117560002Search in Google Scholar

Waalkes MP, Rehm S, Riggs CW, Bare RM, Devor DE, Poirier LA, Wenk ML, Henneman JR. Cadmium carcinogenesis in male wistar [Crl:(WI)BR] rats: Doseresponse analysis of effects of zinc on tumor induction in the prostate, in the testes, and at the injection site. Cancer Res 1989;49:4282-8.Search in Google Scholar

Hu Y, Jin T, Zhou T, Pang B, Wang Y. Effects of zinc on gene expressions induced by cadmium in prostate and testes of rats. Biometals 2004;17:571-2.10.1023/B:BIOM.0000045835.21954.c7Search in Google Scholar

Bulat PZ, Djukić-Ćosić D, Maličević Ž, Bulat P, Matović V. Zinc or magnesium supplementation modulates Cd intoxication in blood, kidney, spleen, and bone of rabbits. Biol Trace Elem Res 2008;124:110-7.10.1007/s12011-008-8128-518418555Search in Google Scholar

Bridges CC, Zalups RK. Molecular and ionic mimicry and the transport of toxic metals. Toxicol Appl Pharm 2005;204:274-308.10.1016/j.taap.2004.09.007240929115845419Search in Google Scholar

Jihen EH, Fatima H, Nouha A, Baati T, Imed M, Abdelhamid K. Cadmium retention increase: A probable key mechanism of the protective effect of zinc on cadmium-induced toxicity in the kidney. Toxicol Lett 2010;196:104-9.10.1016/j.toxlet.2010.04.00620394811Search in Google Scholar

Boujelben M, Ghorbel F, Vincent C, Makni-Ayadi F, Guermazi F, Croute F, El-Feki A. Lipid peroxidation and HSP72/73 expression in rat following cadmium chloride administration: Interactions of magnesium supplementation. Exp Toxicol Pathol 2006;57:437-43.10.1016/j.etp.2006.02.01216616466Search in Google Scholar

Djukić-Ćosić D, Ninković M, Maličević Z, Plamenac-Bulat Z, Matović V. Effect of supplemental magnesium on the kidney levels of cadmium, zinc, and copper of mice exposed to toxic levels of cadmium. Biol Trace Elem Res 2006;114:281-92.10.1385/BTER:114:1:281Search in Google Scholar

Blanuša M, Varnai VM, Piasek M, Kostial K. Chelators as antidotes of metal toxicity: therapeutic and experimental aspects. Curr Med Chem 2005;12:2771-94.10.2174/092986705774462987Search in Google Scholar

Brzóska MM, Galazyn-Sidorczuk M, Rogalska J, Roszczenko A, Jurczuk M, Majewska K, Moniuszko-Jakoniuk J. Beneficial effect of zinc supplementation on biomechanical properties of femoral distal end and femoral diaphysis of male rats chronically exposed to cadmium. Chem Biol Interact 2008;171:312-24.10.1016/j.cbi.2007.11.007Search in Google Scholar

Rogalska J, Brzóska MM, Roszczenko A, Moniuszko-Jakoniuk J. Enhanced zinc consumption prevents cadmium-induced alterations in lipid metabolism in male rats. Chem Biol Interact 2009;177:142-52.10.1016/j.cbi.2008.09.011Search in Google Scholar

Waalkes MP. Cadmium carcinogenesis. Mutat Res 2003;533:107-20.10.1016/j.mrfmmm.2003.07.011Search in Google Scholar

Liu X, Jin T, Nodberg GF, Rännar S, Sjöström M, Zhou Y. A multivariate study of protective effects of Zn and Cu against nephrotoxicity induced by cadmium metallothionein in rats. Toxicol Appl Pharmacolacol 1992;114:239-45.10.1016/0041-008X(92)90074-3Search in Google Scholar

Turgut S, Enli Y, Emmungil G, Turgut G, Demir S, Kaptanoglu B, Genc O. Influence of cadmium and copper on tissue element levels of pregnant rats. Cent Eur J Med 2007;2:447-57.10.2478/s11536-007-0047-xSearch in Google Scholar

Matović V, Plamenac-Bulat Z, Djukić-Ćosić D, Soldatović D. Zinc, copper or magnesium supplementation against cadmium toxicity: an experimental study. In: Blanc G, Moreu D, editors. Biometals: Molecular Structures, Binding Properties and Applications. 1st ed. New York (NY): Nova Science Publisher; 2010. p. 1-31.Search in Google Scholar

Matović V, Soldatović D, Vujanović D. Magnesium against lead: new approach to prophylaxis and therapy of chronic lead intoxication. In: Kotsaki-Kovatsi VP, Vafiadu AJ, editors. Aspects on Environmental Toxicology. Thessaloniki: Tecnika Studio; 1995. p. 78-82.Search in Google Scholar

Soldatović D, Matović V, Vujanović D. Prophylactic effect of high magnesium intake in rabbits exposed to prolonged lead intoxication. Magnes Res 1993;6:145-8.Search in Google Scholar

Soldatović D, Vujanović D, Matović V, Stojanović Z. Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits. Magnes Res 1997;10:127-33.Search in Google Scholar

Soldatović D, Matović V. Influence of magnesium on the urinary lead excretion in rabbits submitted to chronic lead intoxication. In: Chhaparwal B, Durlach J, editors. Magnesium Research New Vistas. Indora: India; 1999. p. 125-31.Search in Google Scholar

Soldatović D, Matović V, Vujanović D, Guiet-Bara A, Bara M, Durlach J. Metal pollutants and bioelements: retrospective of interactions between magnesium and toxic metals. Magnes Res 2002;15:67-72.Search in Google Scholar

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Medicine, Basic Medical Science, other